7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Product Name: 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS No.: 442666-98-0
Chemical Name: 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
Synonyms: Anguizole;7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-
CBNumber: CB62589615
Molecular Formula: C17H11ClF2N4O2S
Formula Weight: 408.81
MOL File: 442666-98-0.mol

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7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Property

Density: 1.59
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 9.14±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0558
Product name: Anguizole
Purity: 99.48%
Packaging: 5mg
Price: $130
Updated: 2021/12/16

ApexBio Technology

Product number: A3182
Product name: Anguizole
Packaging: 5mg
Price: $159
Updated: 2021/12/16

ChemScene

Product number: CS-0558
Product name: Anguizole
Purity: 99.48%
Packaging: 10mg
Price: $216
Updated: 2021/12/16

ApexBio Technology

Product number: A3182
Product name: Anguizole
Packaging: 10mg
Price: $264
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001852
Product name: ANGUIZOLE
Purity: 95.00%
Packaging: 5MG
Price: $279.4
Updated: 2021/12/16

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7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical Properties,Usage,Production

Biological Activity

anguizole is a selective inhibitor of ns4b with ic50 value of 310 nm [1].ns4b (nonstructural protein 4b) is a viral protein which was found in hepatitis c virus and was a key regulator in hcv replication complex formation. it is reported that ns4b plays a pivotal role in hcv replication via inducing a specific membrane rearrangement and designating membranous web. ns4b-ah2, comprising amino acid 42 to 66, is identified as a major regulator for ns4b oligomerization [2].anguizole is a potent ns4b inhibitor and targets the second amphipathic helix of ns4b (ns4b-ah2). when tested with hcv virus, anguizole treatment significantly disrupted ns4b-ah2-mediated biological functions of ns4b which played an important role in hcv life cycle [3]. in huh7.5 cells transferring a plasmid expressing ns4b fused in frame with gfp, 5μm anguizole treatment (48 hours) altered the distribution of ns4b maf pattern which inhibited hcv life cycle [1].

target

HCV

References

[1]. bryson, p.d., et al., a small molecule inhibits hcv replication and alters ns4b's subcellular distribution. antiviral res, 2010. 87(1): p. 1-8.
[2]. gouttenoire, j., et al., aminoterminal amphipathic alpha-helix ah1 of hepatitis c virus nonstructural protein 4b possesses a dual role in rna replication and virus production. plos pathog, 2014. 10(10): p. e1004501.
[3]. choi, m., et al., a hepatitis c virus ns4b inhibitor suppresses viral genome replication by disrupting ns4b's dimerization/multimerization as well as its interaction with ns5a. virus genes, 2013. 47(3): p. 395-407.

7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide Suppliers

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442666-98-0, 7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamideRelated Search:

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Anguizole

7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-

442666-98-0

C17H11ClF2N4O2S