ChemicalBook > CAS DataBase List > (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid

Product Name
(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid
CAS No.
74761-42-5
Chemical Name
(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid
Synonyms
(methoxycarbonyl)-L-valine;MOC-L-Valine;N-(Methoxycarbonyl)-L-valine;MOC-L;MOC-Val;MOC-L-Val;Moc-Val-OH;Moc-L-Val-OH;Methoxycarbonyl valine;Oliceridine Impurity 8
CBNumber
CB62593005
Molecular Formula
C7H13NO4
Formula Weight
175.18
MOL File
74761-42-5.mol
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(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Property

Melting point:
109.0 to 113.0 °C
Boiling point:
315.9±25.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
4.44±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C7H13NO4/c1-4(2)5(6(9)10)8-7(11)12-3/h4-5H,1-3H3,(H,8,11)(H,9,10)/t5-/m0/s1
InChIKey
CEFVHPDFGLDQKU-YFKPBYRVSA-N
SMILES
C(O)(=O)[C@H](C(C)C)NC(OC)=O
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2857
Product name
N-(Methoxycarbonyl)-L-valine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
M2857
Product name
N-(Methoxycarbonyl)-L-valine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$51
Updated
2024/03/01
TRC
Product number
M219945
Product name
(S)-2-((Methoxycarbonyl)amino)-4-methylbutanoicAcid
Packaging
1g
Price
$60
Updated
2021/12/16
TRC
Product number
M219945
Product name
(S)-2-((Methoxycarbonyl)amino)-4-methylbutanoicAcid
Packaging
5g
Price
$75
Updated
2021/12/16
Activate Scientific
Product number
AS90227
Product name
(S)-2-[(Methoxycarbonyl)amino]-3-methylbutyric Acid
Purity
98+% ee
Packaging
100g
Price
$113
Updated
2021/12/16
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(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Chemical Properties,Usage,Production

Uses

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid can be used as Ledipasvir Intermediate, mainly used in laboratory R&D process and chemical production process.

Synthesis


Na2CO3 (1.83 g, 17.2 mmol) was added to an aq solution of NaOH (33 mL of 1 M/H2O, 33 mmol) and L-valine (3.900 g, 33.29 mmol) and the resulting solution was cooled with ice-water bath. Methyl chloroformate (2.8 mL, 36.1 mmol) was added dropwise, the cooling bath was removed and the reaction mixture was stirred at ambient temperature for 3.25 h. The reaction mixture was washed with ether (3x17 mL), and the aqueous phase was cooled with ice-water bath and acidified with conc HCl to a pH of 1-2, and extracted with CH2Cl2 (3x17 mL). The organic phase was dried (anhyd MgSO4), filtered, and concentrated in vacuo. Cap-1 as a white solid (5.00 g, 86%).

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Suppliers

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View Lastest Price from (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
MOC-L-Valine 74761-42-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%min
Supply Ability
10 tons
Release date
2021-08-09
Hebei Mojin Biotechnology Co., Ltd
Product
(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 74761-42-5
Price
US $50.00/KG
Min. Order
25KG
Purity
98
Supply Ability
200ton
Release date
2023-08-17
Chengdu Baishixing Science and Technology Industry Co.,Ltd
Product
MOC-L-Valine 74761-42-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5T/month
Release date
2023-07-26

74761-42-5, (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acidRelated Search:

Ledipasvir Moc-Leu-OH (2R)-1-methoxycarbonylpyrrolidine-2-carboxylic acid Moc-Ile-OH Moc-Val-Val-OH 1,2-Pyrrolidinedicarboxylicacid,1-methylester,(2S)-(9CI) MOC-D-Valine Methoxycarbonyl-L-tert-leucine Benzeneacetic acid, a-[(Methoxycarbonyl)aMino]-, (S)- (R)-2-(methoxycarbonylamino)-2-phenylacetic acid ledipasvir interMediate ledipasvir interMediate 2,7-DibroMo-9,9-difluoro-9H-fluorene (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-(6-broMo-1H-benziMidazol-2-yl)-, 1,1-diMethylethyl ester,(1R,3S,4S)- (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone ledipasvir interMediate

  • (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid
  • Methoxycarbonyl valine
  • (Synonyms:N-(methoxycarbonyl)-L-Valine)
  • N-(Methoxycarbonyl)-L-valine
  • MOC-L-Valine
  • L-Valine, N-(Methoxycarbonyl)-
  • Moc-Val-OH
  • N-(methoxycarbonyl)-Valine
  • (2S)-2-[(Methoxycarbonyl)aMino]-3-Methylbutanoic acid
  • MOC-L-Val
  • MOC-Val
  • Moc-L-Val-OH
  • <i>N</i>-(Methoxycarbonyl)-<small>L</small>-valine
  • (methoxycarbonyl)-L-valine
  • (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic
  • 2-Methoxycarbonylamino-3-methyl-butyric acid
  • (S)-2-[(Methoxycarbonyl)amino]-3-methylbutyric Acid
  • MOC-L
  • (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoicaci
  • (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid USP/EP/BP
  • (S)-2-((Methoxycarbonyl)amino)-4-methylbutanoic Acid
  • (S)-2-((Methoxycarbonyl)aMino)-3-MethylbutaChemicalbooknoicacid
  • Moc-L-Valine (N-(Methoxycarbonyl)-L-Valine)
  • (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acidQ: What is (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid Q: What is the CAS Number of (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid Q: What is the storage condition of (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid Q: What are the applications of (S)-2-((Methoxycarbonyl)amino)-3-methylbutanoic acid
  • Oliceridine Impurity 8
  • 74761-42-5
  • 6885-20-8
  • Pharmaceuticalintermediates