TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

Product Name: TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
CAS No.: 223131-01-9
Chemical Name: TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
Synonyms: tert-butyl cis-N-(4-aminocyclohexyl)carbamate;cis-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane;TERT-BUTYL CIS-4-(HYDROXYMETHYL)CYCLOHEXYLCABAMATE;tert-Butyl N-[4-(hydroxymethyl)cyclohexyl]carbamate;cis-1-(Boc-aMino)-4-(hydroxyMethyl)cyclohexane, 97%;TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE;Cis tert-butyl -4-(hydroxymethyl)cyclohexyl)carbamate;tert-butyl N-[cis-4-(hydroxymethyl)cyclohexyl]carbamate;tert-butyl (1s,4s)-4-(hydroxymethyl)cyclohexylcarbamate;tert-butyl cis-N-[4-(hydroxymethyl)cyclohexyl]carbamate
CBNumber: CB6259321
Molecular Formula: C12H23NO3
Formula Weight: 229.32
MOL File: 223131-01-9.mol

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TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Property

storage temp.: 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB56958
Product name: Tert-Butyl Cis-(4-Hydroxymethyl)Cyclohexylcarbamate
Packaging: 100mg
Price: $156
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56958
Product name: Tert-Butyl Cis-(4-Hydroxymethyl)Cyclohexylcarbamate
Packaging: 250mg
Price: $195
Updated: 2021/12/16

Matrix Scientific

Product number: 089352
Product name: tert-Butyl cis-(4-hydroxymethyl)-cyclohexylcarbamate
Packaging: 250mg
Price: $269
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56958
Product name: Tert-Butyl Cis-(4-Hydroxymethyl)Cyclohexylcarbamate
Packaging: 500mg
Price: $435
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0303487
Product name: TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $498.48
Updated: 2021/12/16

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TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Chemical Properties,Usage,Production

Synthesis

24424-99-5

30134-98-6

223131-01-9

General procedure for the synthesis of cis-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane from di-tert-butyl dicarbonate and (1r,4r)-4-aminocyclohexanemethanol: Di-tert-butyl dicarbonate (3.04 g, 13.9 mmol) was slowly added to (1r,4r)-4-aminocyclohexanemethanol (1.50 g, 11.6 mmol) in a room temperature tetrahydrofuran (20 mL) in a stirred solution. The reaction mixture was stirred overnight at room temperature. Subsequently, the solvent was removed by rotary evaporation and the residue was partitioned between ethyl acetate and water. The organic phase was separated, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, and the solvent was again removed by rotary evaporation. The resulting residue was treated with hexane and the suspension formed was filtered to give cis-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane as a white solid (2.11 g, 79% yield). The product was detected by low resolution mass spectrometry (LRMS) and showed m/z of 228 (M-H)+.1H NMR (DMSO-d6) δ: 0.84-0.95 (m, 2H), 1.05-1.18 (m, 2H), 1.20-1.29 (m, 2H), 1.40 (s, 9H), 1.71-1.80 (m, 3H), 3.14 (m , 1H), 3.21 (t, 2H), 4.41 (t, 1H), 6.73 (d, 1H).

References

[1] Patent: EP2554544, 2013, A1. Location in patent: Paragraph 0161
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1999, vol. 42, # SUPPL. 1, p. S309-S310,S311
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 1999, vol. 42, # 3, p. 293 - 307
[4] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0274

TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Suppliers

China 63 Hungary 1 India 2 United Kingdom 1 United States 10 Global 77

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223131-01-9, TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATERelated Search:

Cyclohexanecarboxylic acid, 4-(cyclopropylamino)-, ethyl ester, cis- Cyclohexaneacetic acid, 4-(4-hydroxyphenyl)-, Methyl ester, cis- cis-tert-butyl 3-aMinocyclobutanecarboxylate hydrochloride (3R,5S)-3,5-diMethylMorpholine cis-tert-butyl 3-hydroxycyclobutanecarboxylate cis-3-Methylcyclobutanamine hydrochloride BOC-1,4-TRANS-ACHC-OH TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE 4-TERT-BUTOXYCARBONYLAMINO-CUBANE-1-CARBOXYLIC ACID 4-(TERT-BUTOXYCARBONYLAMINO)BICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID 4-(BOC-AMINO)CYCLOHEXANECARBOXYLIC ACID METHYL 4-(TERT-BUTYLCARBONYLAMINO)CUBANECARBOXYLATE FMOC-1, 1-ACCH(4-AMINO-BOC) 1-BOC-AMINOCYCLOHEXANE-1,4-DICARBOXYLIC ACID BOC-TRANS-1,4-AMINO-1-CYCLOHEXANE CARBOXYLIC ACID 1, 1-ACCH(4-AMINO-BOC)-OME BOC-(4-CIS/TRANS)-1, 1-ACCH(4-CH2OH)

TERT-BUTYL CIS-4-(HYDROXYMETHYL)CYCLOHEXYLCABAMATE

cis-1-(Boc-aMino)-4-(hydroxyMethyl)cyclohexane, 97%

tert-Butyl N-[4-(hydroxymethyl)cyclohexyl]carbamate

Cis tert-butyl -4-(hydroxymethyl)cyclohexyl)carbamate

TERT-BUTYL CIS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

tert-butyl (1s,4s)-4-(hydroxymethyl)cyclohexylcarbamate

tert-butyl N-[cis-4-(hydroxymethyl)cyclohexyl]carbamate

Carbamic acid, N-[cis-4-(hydroxymethyl)cyclohexyl]-, 1,1-dimethylethyl ester

tert-butyl cis-N-[4-(hydroxymethyl)cyclohexyl]carbamate

tert-butyl cis-N-(4-aminocyclohexyl)carbamate

cis-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane

223131-01-9