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DeMethyleneberberine

Product Name
DeMethyleneberberine
CAS No.
25459-91-0
Chemical Name
DeMethyleneberberine
Synonyms
DeMethyleneberberine;DeMethyleneberberine USP/EP/BP;Demethyleneberberine - Bio-X ?;Demethyleneberberine, 10 mM in DMSO;2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoqu...;Dibenzo[a,g]quinoliziniuM,5,6-dihydro-2,3-dihydroxy-9,10-diMethoxy;2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium;9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol;2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
CBNumber
CB62610281
Molecular Formula
C19H18NO4+
Formula Weight
324.36
MOL File
25459-91-0.mol
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DeMethyleneberberine Property

storage temp. 
4°C, protect from light
solubility 
DMSO : 33.33 mg/mL (102.76 mM; Need ultrasonic)
form 
powder
color 
Yellow
InChI
InChI=1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1
InChIKey
HVTCKKMWZDDWOY-UHFFFAOYSA-O
SMILES
OC1=C(C=C2CC[N+]3=CC4=C(C(OC)=CC=C4C=C3C2=C1)OC)O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD74150
Product name
Demethyleneberberine
Packaging
5mg
Price
$86
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD74150
Product name
Demethyleneberberine
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0009603
Product name
Demethyleneberberine
Purity
98.09%
Packaging
10mg
Price
$290
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD74150
Product name
Demethyleneberberine
Packaging
25mg
Price
$300
Updated
2021/12/16
ApexBio Technology
Product number
N2087
Product name
Demethyleneberberine
Packaging
10mg
Price
$450
Updated
2021/12/16
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DeMethyleneberberine Chemical Properties,Usage,Production

Chemical Properties

Yellow crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Phellodendron chinense.

Uses

Demethyleneberberine is a naturally occurring alkaloid in plants that displays anti-adipogenic effects and is also shown to alleviate IBS.

Biological Activity

Demethyleneberberine, a berberine metabolite, is a mitochondria-targeted antioxidant isolated from Cortex Phellodendri chinensis th at exhibits multiple pharmacological activities including anti-microbial, anti-inflammatory, anti-diarrhea and anti-cancer. Demethyleneberberine alleviates ethanol-dependent oxidative stress by suppression of cytochrome CYP2E1 (P450 2E1), hypoxia inducible factor α (HIF-1α) and inducible nitric oxide synthase (iNOS). It appears th at demethyleneberberine attenuates non-alcoholic fatty liver disease (NAFLD) through activation of AMPK.

target

P450 (e.g. CYP17) | HIF | NOS

DeMethyleneberberine Preparation Products And Raw materials

Raw materials

Preparation Products

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DeMethyleneberberine Suppliers

Canada 1 CHINA 159 United Kingdom 1 United States 10 Global 171
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from DeMethyleneberberine manufacturers

R&D Scientific Inc.
Product
Demethyleneberberine 25459-91-0
Price
US $1400.00/g
Min. Order
1g
Purity
98
Supply Ability
50 Kg
Release date
2024-11-28
Shanghai Standard Technology Co., Ltd.
Product
Demethyleneberberine 25459-91-0
Price
US $0.00/mg
Min. Order
10mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-05-06
Career Henan Chemical Co
Product
DeMethyleneberberine 25459-91-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

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  • DeMethyleneberberine
  • Dibenzo[a,g]quinoliziniuM,5,6-dihydro-2,3-dihydroxy-9,10-diMethoxy
  • 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
  • 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
  • 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
  • DeMethyleneberberine USP/EP/BP
  • 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoqu...
  • Demethyleneberberine, 10 mM in DMSO
  • Demethyleneberberine - Bio-X ?
  • 25459-91-0
  • C19H18NO4
  • Alkaloids
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical