ChemicalBook > CAS DataBase List > 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

Product Name
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS No.
3605-01-4
Chemical Name
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonyms
PIRIBEDIL;ET-495;EU-4200;Piribedi;Pirbedil;Trivastan;Trivastal;Piribendyl;PIRIBEDIOL;Piribedil>
CBNumber
CB6261328
Molecular Formula
C16H18N4O2
Formula Weight
298.34
MOL File
3605-01-4.mol
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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Property

Melting point:
98°
Boiling point:
439.76°C (rough estimate)
Density 
1.1183 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
7.17±0.10(Predicted)
form 
Solid
color 
White
Merck 
14,7493
CAS DataBase Reference
3605-01-4(CAS DataBase Reference)
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Safety

RTECS 
UV9704000
HS Code 
2933.59.8000
Toxicity
LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2054
Product name
Piribedil
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
P2054
Product name
Piribedil
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$69
Updated
2021/12/16
Usbiological
Product number
019806
Product name
Piribedil
Packaging
100mg
Price
$460
Updated
2021/12/16
TRC
Product number
P508750
Product name
Piribedil
Packaging
100mg
Price
$150
Updated
2021/12/16
TRC
Product number
P508750
Product name
Piribedil
Packaging
1g
Price
$1190
Updated
2021/12/16
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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Trivastal, Eutherapie ,France,1969

Uses

Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.

Definition

ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.

Manufacturing Process

To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.

Therapeutic Function

Vasodilator

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Suppliers

Canada 1 China 143 France 1 Germany 2 India 7 Japan 1 South Korea 1 The Netherlands 1 United Kingdom 5 United States 17 Global 179
Xiamen Weijia Pharma Co., Ltd
Tel
0592-6055939 18950006030
Email
lzf@xmweijia.com
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China
ProdList
55
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
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China
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BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
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65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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View Lastest Price from 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Hebei Mojin Biotechnology Co., Ltd
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-19
Dideu Industries Group Limited
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26

3605-01-4, 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidineRelated Search:

4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)pyrocatechol hydrochloride hydrate (2:4:1) Piribedil-d8 Pirenoxine Entacapone CYCLAZOSIN HYDROCHLORIDE Gabapentin PIRIBEDIL HYDROCHLORIDE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 2-(4-[1,3-BENZODIOXOL-5-YLMETHYL]-1-PIPERAZINYL)PYRIMIDINE MALEATE SALT 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7-(THIOPHEN-2-YL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]-7-[(E)-2-PHENYLETHENYL]-7,8-DIHYDRO-5(6H)-QUINAZOLINONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(FURAN-2-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

  • PIRIBEDIL
  • Piribendyl
  • 2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine
  • 1-(2-Pyrimidyl)-4-piperonylpiperazine
  • PIRIBEDIL(FORR&DONLY0
  • PIRIBEDIOL
  • ET-495
  • EU-4200
  • Trivastal
  • Trivastan
  • 2-(4-Piperonyl-1-piperazinyl)-Pyrimidine
  • 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
  • Pipidil Control
  • Piribedil&gt
  • Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-
  • PIRIBEDIL USP/EP/BP
  • 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP
  • Piribedi
  • Pirbedil
  • 3605-01-4
  • 3605/1/4
  • 622744
  • Isotope labelled API
  • API