ChemicalBook > CAS DataBase List > 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

Product Name
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS No.
3605-01-4
Chemical Name
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonyms
PIRIBEDIL;ET-495;EU-4200;Piribedi;Pirbedil;Trivastan;Trivastal;Piribendyl;PIRIBEDIOL;Piribedil>
CBNumber
CB6261328
Molecular Formula
C16H18N4O2
Formula Weight
298.34
MOL File
3605-01-4.mol
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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Property

Melting point:
98°
Boiling point:
439.76°C (rough estimate)
Density 
1.1183 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
7.17±0.10(Predicted)
form 
Solid
color 
White
Merck 
14,7493
InChI
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
InChIKey
OQDPVLVUJFGPGQ-UHFFFAOYSA-N
SMILES
C1(N2CCN(CC3=CC=C4OCOC4=C3)CC2)=NC=CC=N1
CAS DataBase Reference
3605-01-4(CAS DataBase Reference)
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Safety

RTECS 
UV9704000
HS Code 
2933.59.8000
Toxicity
LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2054
Product name
Piribedil
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
P2054
Product name
Piribedil
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$69
Updated
2021/12/16
TRC
Product number
P508750
Product name
Piribedil
Packaging
100mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
019806
Product name
Piribedil
Packaging
100mg
Price
$460
Updated
2021/12/16
TRC
Product number
P508750
Product name
Piribedil
Packaging
1g
Price
$1190
Updated
2021/12/16
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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Trivastal, Eutherapie ,France,1969

Uses

Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.

Definition

ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.

Manufacturing Process

To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.

Therapeutic Function

Vasodilator

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 27, p. 9656 - 9661
[2] ChemCatChem, 2014, vol. 6, # 3, p. 808 - 814
[3] Chemistry - A European Journal, 2013, vol. 19, # 11, p. 3665 - 3675
[4] Journal of Organic Chemistry, 2011, vol. 76, # 7, p. 2328 - 2331
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8263 - 8265

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Suppliers

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View Lastest Price from 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Dideu Industries Group Limited
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

3605-01-4, 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidineRelated Search:

4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)pyrocatechol hydrochloride hydrate (2:4:1) Piribedil-d8 Pirenoxine Entacapone CYCLAZOSIN HYDROCHLORIDE Gabapentin PIRIBEDIL HYDROCHLORIDE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 2-(4-[1,3-BENZODIOXOL-5-YLMETHYL]-1-PIPERAZINYL)PYRIMIDINE MALEATE SALT 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7-(THIOPHEN-2-YL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]-7-[(E)-2-PHENYLETHENYL]-7,8-DIHYDRO-5(6H)-QUINAZOLINONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(FURAN-2-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

  • PIRIBEDIL
  • Piribendyl
  • 2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine
  • 1-(2-Pyrimidyl)-4-piperonylpiperazine
  • PIRIBEDIL(FORR&DONLY0
  • PIRIBEDIOL
  • ET-495
  • EU-4200
  • Trivastal
  • Trivastan
  • 2-(4-Piperonyl-1-piperazinyl)-Pyrimidine
  • 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
  • Pipidil Control
  • Piribedil&gt
  • Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-
  • PIRIBEDIL USP/EP/BP
  • 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP
  • Piribedi
  • Pirbedil
  • Piribedil, 10 mM in DMSO
  • 3605-01-4
  • 3605/1/4
  • 622744
  • Isotope labelled API
  • API