ChemicalBook > CAS DataBase List > 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

Product Name
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
CAS No.
3605-01-4
Chemical Name
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonyms
PIRIBEDIL;ET-495;EU-4200;Piribedi;Pirbedil;Trivastan;Trivastal;Piribendyl;PIRIBEDIOL;Piribedil>
CBNumber
CB6261328
Molecular Formula
C16H18N4O2
Formula Weight
298.34
MOL File
3605-01-4.mol
More
Less

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Property

Melting point:
98°
Boiling point:
439.76°C (rough estimate)
Density 
1.1183 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
7.17±0.10(Predicted)
form 
Solid
color 
White
Merck 
14,7493
CAS DataBase Reference
3605-01-4(CAS DataBase Reference)
More
Less

Safety

RTECS 
UV9704000
HS Code 
2933.59.8000
Toxicity
LD50 in mice (mg/kg): 88 i.v., 690 i.p., 1460 orally (Laubie)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
P2054
Product name
Piribedil
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
P2054
Product name
Piribedil
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$69
Updated
2021/12/16
Usbiological
Product number
019806
Product name
Piribedil
Packaging
100mg
Price
$460
Updated
2021/12/16
TRC
Product number
P508750
Product name
Piribedil
Packaging
100mg
Price
$150
Updated
2021/12/16
TRC
Product number
P508750
Product name
Piribedil
Packaging
1g
Price
$1190
Updated
2021/12/16
More
Less

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Trivastal, Eutherapie ,France,1969

Uses

Piribedil is an antiparkisonian agent that acts as a dopamine agonist. Piribedil also displays α2-adrenergic antagonist properties. Piribedil has also been shown to counteract age-related memory impairment by improving memory and attention as well as increasing the velocity of psychomotor reactions and lability of nervous processes.

Definition

ChEBI: 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.

Manufacturing Process

To a solution of 21 g of 1-(3':4'-methylenedioxybenzyl)-piperazine in solution in 300 cc of anhydrous xylene there were added 28 g of anhydrous potassium carbonate and then 11.3 g of 2-chloropyrimidine. The suspension was then heated for 9 hours at boiling point (130°C). After this time, the mixture was cooled and extracted several times with 10% hydrochloric acid. The acid solution obtained was washed with ether and then rendered alkaline with potassium carbonate; the oily product which was separated was extracted with chloroform and this, after drying with potassium carbonate and evaporation, gave an oily residue weighing 20 g. By dissolution in boiling ethanol and crystallization, 15 g of crystals melting at 96°C were recovered.

Therapeutic Function

Vasodilator

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine Suppliers

Canada 1 China 145 France 1 Germany 2 India 7 Japan 1 South Korea 1 The Netherlands 1 United Kingdom 5 United States 17 Global 181
Xiamen Weijia Pharma Co., Ltd
Tel
0592-6055939 18950006030
Email
lzf@xmweijia.com
Country
China
ProdList
55
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2045
Advantage
56
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
Suzhou Huihe Pharmaceutical Co. Ltd.
Tel
86-0512-88819360,88985990
Fax
86-0512-86876095
Email
asynderm@163.com
Country
China
ProdList
90
Advantage
60
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2964
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1977
Advantage
55
Guangzhou Kafen Biotech Co.,Ltd
Tel
18029243487 2355327168
Fax
020-31121510
Email
gy@yccreate.com
Country
China
ProdList
4749
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4016
Advantage
58
Suzhou Shanyang Pharmaceutical Technology Co.,
Tel
0512-63268889 18506119477
Email
82169840@qq.com
Country
China
ProdList
529
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9577
Advantage
60
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28806
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Zhuhai JiaYi Biological Technology Co., Ltd.
Tel
18578209868 2355327026
Fax
18578209868 QQ：2355327026
Email
steroidbest@hotmail.com
Country
China
ProdList
6501
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29791
Advantage
60
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
8895
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9639
Advantage
58
Hebei Mojin Biotechnology Co., Ltd
Tel
+86 13288715578 +8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12839
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Hubei Ipure Biology Co., Ltd
Tel
+8613367258412
Fax
18062427325
Email
ada@ipurechemical.com
Country
China
ProdList
10319
Advantage
58
CD Chemical Group Limited
Tel
+8615986615575
Fax
0086-13651442114
Email
info@codchem.com
Country
China
ProdList
20342
Advantage
58
More
Less

View Lastest Price from 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Hebei Mojin Biotechnology Co., Ltd
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-19
Dideu Industries Group Limited
Product
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 3605-01-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26

3605-01-4, 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidineRelated Search:

4-((4-(2-Pyrimidinyl)-1-piperazinyl)methyl)pyrocatechol hydrochloride hydrate (2:4:1) Piribedil-d8 Pirenoxine Entacapone CYCLAZOSIN HYDROCHLORIDE Gabapentin PIRIBEDIL HYDROCHLORIDE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 2-(4-[1,3-BENZODIOXOL-5-YLMETHYL]-1-PIPERAZINYL)PYRIMIDINE MALEATE SALT 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7-(THIOPHEN-2-YL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]-7-[(E)-2-PHENYLETHENYL]-7,8-DIHYDRO-5(6H)-QUINAZOLINONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(FURAN-2-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(4-ISOPROPYLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

  • PIRIBEDIL
  • Piribendyl
  • 2-(4-(benzo[d][1,3]dioxol-5-ylMethyl)piperazin-1-yl)pyriMidine
  • 1-(2-Pyrimidyl)-4-piperonylpiperazine
  • PIRIBEDIL(FORR&DONLY0
  • PIRIBEDIOL
  • ET-495
  • EU-4200
  • Trivastal
  • Trivastan
  • 2-(4-Piperonyl-1-piperazinyl)-Pyrimidine
  • 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
  • Pipidil Control
  • Piribedil&gt
  • Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-
  • PIRIBEDIL USP/EP/BP
  • 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine USP/EP/BP
  • Piribedi
  • Pirbedil
  • 3605-01-4
  • 3605/1/4
  • 622744
  • Isotope labelled API
  • API