ChemicalBook > CAS DataBase List > PIRIBEDIL HYDROCHLORIDE

PIRIBEDIL HYDROCHLORIDE

Product Name
PIRIBEDIL HYDROCHLORIDE
CAS No.
78213-63-5
Chemical Name
PIRIBEDIL HYDROCHLORIDE
Synonyms
PiribedilHCl;PIRIBEDIL HYDROCHLORIDE;Piribedil dihydrochloride;2-(4-piperonyl-1-piperazinyl)-pyrimidinhydrochloride;2-(4-piperonyl-1-piperazinyl)pyrimidinehydrochloride;2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-pyrimidinmonohydrochlor;2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINE HYDROCHLORIDE;2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINIE HYDROCHLORIDE;2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidinedihydrochloride
CBNumber
CB6338079
Molecular Formula
C16H19ClN4O2
Formula Weight
334.8
MOL File
78213-63-5.mol
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PIRIBEDIL HYDROCHLORIDE Property

storage temp. 
Store at RT
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1031
Product name
Piribedildihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$145
Updated
2021/12/16
Tocris
Product number
1031
Product name
Piribedildihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$609
Updated
2021/12/16
TRC
Product number
P508753
Product name
PiribedilDihydrochloride
Packaging
10mg
Price
$100
Updated
2021/12/16
Usbiological
Product number
256263
Product name
Piribedil dihydrochloride
Packaging
10mg
Price
$389
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003874
Product name
PIRIBEDIL HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$255.15
Updated
2021/12/16
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PIRIBEDIL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Piribedil dihydrochloride is a useful dopaminergic for biological research purposes.

Biological Activity

A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D 3 subtype, for which it has 20 times higher affinity than for D 2 , and possesses no significant affinity for D 1 ? receptors.

in vivo

Piribedil hydrochloride (intraperitoneal injection, 5, 15, 40 mg/kg ) alleviates the L-DOPA-induced dyskinesias in rats model of Parkinson’s disease[2].
Piribedil hydrochloride (oral gavage, 4-5 mg/kg, daily for 2 weeks) increases locomotor activity and reversal of motor deficits in adult common marmosets[3].
Piribedil hydrochloride (oral gavage, 150 mg/kg, daily for 21 days) inhibits MLL-r tumor growth and decreases the expression of MLL1 target genes in MV4;11 tumor xenografts[4].

Animal Model:Rat model of Parkinson’s disease[2]
Dosage:5, 15, 40 mg/kg
Administration:Intraperitoneal injection, administered 5 min before administration of L-DOPA.
Result:Reduced turning behaviour and AD (axial dystonia), OD (orolingual dyskinesia) and FD (forelimb dyskinesia) at 5 and 40 mg/kg.
Increased LD (locomotive dyskinesias) at the 40 mg/kg.
Animal Model:Adult common marmosets[3]
Dosage:4-5 mg/kg
Administration:Oral gavage, daily for 2 weeks
Result:Increased vigilance and alertness and reversed the downregulation of preprotachykinin mRNA induced by MPTP in rostral and caudal striatum.

IC 50

D2 Receptor; D3 Receptor

PIRIBEDIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PIRIBEDIL HYDROCHLORIDE Suppliers

China 15 Germany 2 United Kingdom 2 United States 4 Global 23
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
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China
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2208
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55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
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58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Shanghai YuZn Pharm. Technology Co.,Ltd.
Tel
15921286451; 15921286451
Email
2010681527@qq.com
Country
China
ProdList
5182
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58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
DAYANG CHEM (HANGZHOU) CO.,LTD
Tel
+86-88938639 +86-17705817739
Email
info@dycnchem.com
Country
China
ProdList
53899
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58

78213-63-5, PIRIBEDIL HYDROCHLORIDERelated Search:

1-(2-Pyrimidyl)piperazine hydrochloride 2-(1-Piperazinyl)pyrimidine PIRIBEDIL HYDROCHLORIDE 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine 2-(4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)PIPERAZIN-1-YL)-7-(2-CHLOROPHENYL)-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE

  • 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidinedihydrochloride
  • Piribedil dihydrochloride
  • 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-pyrimidinmonohydrochlor
  • 2-(4-piperonyl-1-piperazinyl)pyrimidinehydrochloride
  • 2-(4-piperonyl-1-piperazinyl)-pyrimidinhydrochloride
  • PIRIBEDIL HYDROCHLORIDE
  • PiribedilHCl
  • 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINE HYDROCHLORIDE
  • 2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINIE HYDROCHLORIDE
  • 78213-63-5
  • 3605-1-4
  • C16H18N4O22HCl
  • C16H18N4O2HCl
  • Dopamine receptor