PIRIBEDIL HYDROCHLORIDE
- Product Name
- PIRIBEDIL HYDROCHLORIDE
- CAS No.
- 78213-63-5
- Chemical Name
- PIRIBEDIL HYDROCHLORIDE
- Synonyms
- PiribedilHCl;PIRIBEDIL HYDROCHLORIDE;Piribedil dihydrochloride;2-(4-piperonyl-1-piperazinyl)-pyrimidinhydrochloride;2-(4-piperonyl-1-piperazinyl)pyrimidinehydrochloride;2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-pyrimidinmonohydrochlor;2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINE HYDROCHLORIDE;2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINIE HYDROCHLORIDE;2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidinedihydrochloride
- CBNumber
- CB6338079
- Molecular Formula
- C16H19ClN4O2
- Formula Weight
- 334.8
- MOL File
- 78213-63-5.mol
PIRIBEDIL HYDROCHLORIDE Property
- storage temp.
- Store at RT
N-Bromosuccinimide Price
- Product number
- 1031
- Product name
- Piribedildihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 1031
- Product name
- Piribedildihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $609
- Updated
- 2021/12/16
- Product number
- P508753
- Product name
- PiribedilDihydrochloride
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 256263
- Product name
- Piribedil dihydrochloride
- Packaging
- 10mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- API0003874
- Product name
- PIRIBEDIL HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $255.15
- Updated
- 2021/12/16
PIRIBEDIL HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Piribedil dihydrochloride is a useful dopaminergic for biological research purposes.
Biological Activity
A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D 3 subtype, for which it has 20 times higher affinity than for D 2 , and possesses no significant affinity for D 1 ? receptors.
in vivo
Piribedil hydrochloride (intraperitoneal injection, 5, 15, 40 mg/kg ) alleviates the L-DOPA-induced dyskinesias in rats model of Parkinson’s disease[2].
Piribedil hydrochloride (oral gavage, 4-5 mg/kg, daily for 2 weeks) increases locomotor activity and reversal of motor deficits in adult common marmosets[3].
Piribedil hydrochloride (oral gavage, 150 mg/kg, daily for 21 days) inhibits MLL-r tumor growth and decreases the expression of MLL1 target genes in MV4;11 tumor xenografts[4].
| Animal Model: | Rat model of Parkinson’s disease[2] |
| Dosage: | 5, 15, 40 mg/kg |
| Administration: | Intraperitoneal injection, administered 5 min before administration of L-DOPA. |
| Result: | Reduced turning behaviour and AD (axial dystonia), OD (orolingual dyskinesia) and FD (forelimb dyskinesia) at 5 and 40 mg/kg. Increased LD (locomotive dyskinesias) at the 40 mg/kg. |
| Animal Model: | Adult common marmosets[3] |
| Dosage: | 4-5 mg/kg |
| Administration: | Oral gavage, daily for 2 weeks |
| Result: | Increased vigilance and alertness and reversed the downregulation of preprotachykinin mRNA induced by MPTP in rostral and caudal striatum. |
IC 50
D2 Receptor; D3 Receptor
PIRIBEDIL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PIRIBEDIL HYDROCHLORIDE Suppliers
- Tel
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- Fax
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- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
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- Fax
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- info@biotrend.ch
- Country
- Germany
- ProdList
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