RO-32-0432

Product Name: RO-32-0432
CAS No.: 151342-35-7
Chemical Name: RO-32-0432
Synonyms: RO-32-0432;Ro 31-0432;RO 32-0432 HCL;RO 32-0432 HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI, HCL;BISINDOLYLMALEIMIDE XL, HCL;BISINDOYLMALEIMIDE XI HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI HYDROCHLORIDE;Ro 32 0432 hydrochloride,Ro 320432 hydrochloride;BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
CBNumber: CB6262512
Molecular Formula: C28H28N4O2
Formula Weight: 452.55
MOL File: 151342-35-7.mol

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RO-32-0432 Property

Boiling point:: 712.2±60.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: soluble
form: solid
pka: 7.91±0.60(Predicted)
color: orange

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Safety

WGK Germany: 3
HS Code: 3822000000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1587
Product name: Ro32-0432hydrochloride
Purity: ≥99%(HPLC)
Packaging: 1
Price: $221
Updated: 2021/12/16

Usbiological

Product number: 044610
Product name: Bisindolylmaleimide XI Hydrochloride
Packaging: 1mg
Price: $320
Updated: 2021/12/16

ApexBio Technology

Product number: B6798
Product name: Ro32-0432hydrochloride
Packaging: 1mg
Price: $332
Updated: 2021/12/16

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RO-32-0432 Chemical Properties,Usage,Production

Uses

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .

RO-32-0432 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-32-0432 Suppliers

Canada 1 China 30 Europe 1 Germany 1 Japan 2 Switzerland 2 United Kingdom 3 United States 13 Global 53

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151342-35-7, RO-32-0432Related Search:

6-Ethylindole 1H-Indole, 2,6-dimethyl- Benzeneacetamide, N-(2-(3-indolyl)ethyl)- RO-31-8425 1-Butyl-2-methylindole RARECHEM AN KA 0813 RO-32-0432

RO-32-0432

RO 32-0432 HCL

RO 32-0432 HYDROCHLORIDE

BISINDOLYLMALEIMIDE XI, HCL

BISINDOLYLMALEIMIDE XI HYDROCHLORIDE

BISINDOLYLMALEIMIDE XL, HCL

BISINDOYLMALEIMIDE XI HYDROCHLORIDE

2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL

2-(8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL)-3-(1-METHYLINDOL-3-YL)MALEIMIDE HYDROCHLORIDE

(S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

1H-Pyrrol-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropy rido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-, (S)-

Bisindoylmaleimide XI: 2-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide

3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride

3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride

Ro 31-0432

BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]

1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-

Ro 32 0432 hydrochloride,Ro 320432 hydrochloride

151342-35-7

C28H28N4O2HCl

C28H28N4O2ClH

inhibitor