ChemicalBook > CAS DataBase List > RO-32-0432

RO-32-0432

Product Name
RO-32-0432
CAS No.
151342-35-7
Chemical Name
RO-32-0432
Synonyms
RO-32-0432;Ro 31-0432;RO 32-0432 HCL;RO 32-0432 HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI, HCL;BISINDOLYLMALEIMIDE XL, HCL;BISINDOYLMALEIMIDE XI HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI HYDROCHLORIDE;Ro 32 0432 hydrochloride,Ro 320432 hydrochloride;BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
CBNumber
CB6262512
Molecular Formula
C28H28N4O2
Formula Weight
452.55
MOL File
151342-35-7.mol
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RO-32-0432 Property

Boiling point:
712.2±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
solid
pka
7.91±0.60(Predicted)
color 
orange
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Safety

WGK Germany 
3
HS Code 
3822000000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1587
Product name
Ro32-0432hydrochloride
Purity
≥99%(HPLC)
Packaging
1
Price
$221
Updated
2021/12/16
Usbiological
Product number
044610
Product name
Bisindolylmaleimide XI Hydrochloride
Packaging
1mg
Price
$320
Updated
2021/12/16
ApexBio Technology
Product number
B6798
Product name
Ro32-0432hydrochloride
Packaging
1mg
Price
$332
Updated
2021/12/16
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RO-32-0432 Chemical Properties,Usage,Production

Uses

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .

RO-32-0432 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-32-0432 Suppliers

J & K SCIENTIFIC LTD.
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151342-35-7, RO-32-0432Related Search:


  • RO-32-0432
  • RO 32-0432 HCL
  • RO 32-0432 HYDROCHLORIDE
  • BISINDOLYLMALEIMIDE XI, HCL
  • BISINDOLYLMALEIMIDE XI HYDROCHLORIDE
  • BISINDOLYLMALEIMIDE XL, HCL
  • BISINDOYLMALEIMIDE XI HYDROCHLORIDE
  • 2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL
  • 2-(8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL)-3-(1-METHYLINDOL-3-YL)MALEIMIDE HYDROCHLORIDE
  • (S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • 1H-Pyrrol-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropy rido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-, (S)-
  • Bisindoylmaleimide XI: 2-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide
  • 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride
  • 3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride
  • Ro 31-0432
  • BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
  • 1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-
  • Ro 32 0432 hydrochloride,Ro 320432 hydrochloride
  • 151342-35-7
  • C28H28N4O2HCl
  • C28H28N4O2ClH
  • inhibitor