RO-32-0432
- Product Name
- RO-32-0432
- CAS No.
- 151342-35-7
- Chemical Name
- RO-32-0432
- Synonyms
- RO-32-0432;Ro 31-0432;RO 32-0432 HCL;RO 32-0432 HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI, HCL;BISINDOLYLMALEIMIDE XL, HCL;BISINDOYLMALEIMIDE XI HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI HYDROCHLORIDE;Ro 32 0432 hydrochloride,Ro 320432 hydrochloride;BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
- CBNumber
- CB6262512
- Molecular Formula
- C28H28N4O2
- Formula Weight
- 452.55
- MOL File
- 151342-35-7.mol
RO-32-0432 Property
- Boiling point:
- 712.2±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 7.91±0.60(Predicted)
- color
- orange
Safety
- WGK Germany
- 3
- HS Code
- 3822000000
N-Bromosuccinimide Price
- Product number
- 1587
- Product name
- Ro32-0432hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 1
- Price
- $221
- Updated
- 2021/12/16
- Product number
- 044610
- Product name
- Bisindolylmaleimide XI Hydrochloride
- Packaging
- 1mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- B6798
- Product name
- Ro32-0432hydrochloride
- Packaging
- 1mg
- Price
- $332
- Updated
- 2021/12/16
RO-32-0432 Chemical Properties,Usage,Production
Uses
Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.
Biological Activity
Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .
RO-32-0432 Preparation Products And Raw materials
Raw materials
Preparation Products
RO-32-0432 Suppliers
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