BAM7

ChemicalBook > CAS DataBase List > BAM7

Product Name: BAM7
CAS No.: 331244-89-4
Chemical Name: BAM7
Synonyms: BAM7;CS-970;BAM7; BAM-7;BAM 7, >=98%;BAX activator molecule 7;4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one;3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-Pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone];1H-Pyrazole-4,5-dione, 3-methyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-ethoxyphenyl)hydrazone];(E)-4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one;(4E)-4-[(2-ethoxyphenyl)hydrazinylidene]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)pyrazol-3-one
CBNumber: CB62627364
Molecular Formula: C21H19N5O2S
Formula Weight: 405.47
MOL File: 331244-89-4.mol

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BAM7 Property

Boiling point:: 567.3±52.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
pka: 7.94±0.40(Predicted)
form: powder
color: light orange to dark orange

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14566
Product name: BAM 7
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14566
Product name: BAM 7
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 14566
Product name: BAM 7
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 14566
Product name: BAM 7
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Tocris

Product number: 4810
Product name: BAM7
Purity: ≥99%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

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BAM7 Chemical Properties,Usage,Production

Uses

BAM 7 is a direct and selective activator of proapoptotic Bax with IC50 of 3.3 μM.

Uses

3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-Pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone] or BAM7, is an activator of the proapoptotic BAX used in cancer treatment.

Biological Activity

bam7 is a direct and selective activator of bax with ic50 value of 3.3um [1].in the competitive fluorescence polarization assay (fpa), bam7 competes with fitc–bim sahb for bax binding site(bh3) in a dose dependent manner. bam7 shows no antiapoptotic or bakδc competitive binding interactions even at 50 μm dosing, revealing a remarkable selectivity of bam7 for bax. the interaction between bam7 and bax at the very surface induces the characteristic structural changes that yield functional bax oligomerization. in the in vitro assay, bam7 induces bax-dependent cell death but not the cells with bak. bam7 could be developed to a new generation of apoptotic modulators that directly activate bcl-2 family executioner proteins in cancerand other diseases driven by pathologic apoptotic blockades [1].

Biochem/physiol Actions

BAM7 is a selective activator of BAX, a proapoptotic member of the BCL-2 protein family. BAM7 binds directly to the BAX trigger site, a distinct BH3 binding site that regulates BAX activation, inducing BAX oligomerization, which enables the release of apoptogenic factors that result in cell death. BAM7 is selective for this previously unknown BH3-binding groove on the N-terminal face of BAX.

References

[1] evripidis gavathiotis, denis e reyna, joseph a bellairs, elizaveta s leshchiner, and loren d walensky. direct and selective small-molecule activation of proapoptotic bax. nat chem biol. 2012 july ; 8(7): 639–645.

BAM7 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAM7 Suppliers

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View Lastest Price from BAM7 manufacturers

Career Henan Chemical Co

Product: BAM7 331244-89-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

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3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-Pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]

CS-970

BAM7; BAM-7

1H-Pyrazole-4,5-dione, 3-methyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-ethoxyphenyl)hydrazone]

3-Methyl-1-(4-phenyl-2-thiazolyl)-1H-Pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone] BAM7

4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one

BAX activator molecule 7

BAM 7, >=98%

(4E)-4-[(2-ethoxyphenyl)hydrazinylidene]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)pyrazol-3-one

(E)-4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one

BAM7

4-(2-(2-Ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one

331244-89-4

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