Methyl 5-(broMoMethyl)-2-fluorobenzoate
- Product Name
- Methyl 5-(broMoMethyl)-2-fluorobenzoate
- CAS No.
- 709-45-5
- Chemical Name
- Methyl 5-(broMoMethyl)-2-fluorobenzoate
- Synonyms
- Methyl 5-(broMoMethyl)-2-fluorobenzoate;5-Bromomethyl-2-fluoro-benzoic acid methyl ester;5-(bromomethyl)-2-fluoro-methylester benzoic acid;Benzoic acid, 5-(bromomethyl)-2-fluoro-, methyl ester
- CBNumber
- CB62648514
- Molecular Formula
- C9H8BrFO2
- Formula Weight
- 247.06
- MOL File
- 709-45-5.mol
Methyl 5-(broMoMethyl)-2-fluorobenzoate Property
- Boiling point:
- 304.0±37.0 °C(Predicted)
- Density
- 1.534±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4457DA
- Product name
- Methyl5-(bromomethyl)-2-fluorobenzoate
- Packaging
- 1g
- Price
- $321
- Updated
- 2021/12/16
- Product number
- 2723-B-22
- Product name
- Methyl 5-(bromomethyl)-2-fluorobenzoate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $202
- Updated
- 2021/12/16
- Product number
- 709455
- Product name
- Methyl5-(bromomethyl)-2-fluorobenzoate
- Packaging
- 250mg
- Price
- $221.55
- Updated
- 2021/12/16
- Product number
- AC-6962
- Product name
- Methyl5-(bromomethyl)-2-fluorobenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CD12040802
- Product name
- Methyl5-(bromomethyl)-2-fluorobenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $474
- Updated
- 2021/12/16
Methyl 5-(broMoMethyl)-2-fluorobenzoate Chemical Properties,Usage,Production
Synthesis
816449-70-4
709-45-5
Preparation of methyl 5-(bromomethyl)-2-fluorobenzoate (3): methyl 2-fluoro-5-(hydroxymethyl)benzoate (2) (5 g, 27.17 mmol, 1 eq.) was dissolved in anhydrous dichloromethane (50 mL) followed by addition of phosphorus tribromide (2.19 g, 8.12 mmol, 0.3 eq.). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution and extracted with dichloromethane (3 x 100 mL). The organic phases were combined, washed sequentially with water (3 x 30 mL) and brine (1 x 30 mL), dried over anhydrous sodium sulfate, filtered and concentrated to afford methyl 5-(bromomethyl)-2-fluorobenzoate (3) (4.8 g, 71% yield) as an off-white solid.
References
[1] Patent: WO2016/16316, 2016, A1. Location in patent: Page/Page column 226; 227; 354; 355
Methyl 5-(broMoMethyl)-2-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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