2-Bromo-5-hydroxypyrazine

Uses

Product Name: 2-Bromo-5-hydroxypyrazine
CAS No.: 374063-92-0
Chemical Name: 2-Bromo-5-hydroxypyrazine
Synonyms: 5-Bromopyrazin-2;5-bromopyrazin-2-o;5-bromopyrazin-2-ol;5-BROMO-2-PYRAZINOL;5-Bromopyrazin-2(1H)-one;5-bromo-1H-pyrazin-2-one;5-Bromo-2(1H)-pyrazinone;2-hydroxy-5-bromopyrazine;5-BROMO-2-HYDROXYPYRAZINE;2-BROMO-5-HYDROXY-PYRAZINE
CBNumber: CB6267582
Molecular Formula: C4H3BrN2O
Formula Weight: 174.98
MOL File: 374063-92-0.mol

More

Less

2-Bromo-5-hydroxypyrazine Property

Melting point:: 115-119°C
Density: 2.00±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.02±0.40(Predicted)
form: Crystalline Powder
color: White to light brown
InChI: InChI=1S/C4H3BrN2O/c5-3-1-7-4(8)2-6-3/h1-2H,(H,7,8)
InChIKey: ITTXBHQAWOFJAI-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)N=C1

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 1
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 709735
Product name: 2-Bromo-5-hydroxypyrazine
Purity: 95%
Packaging: 250mg
Price: $56.4
Updated: 2025/07/31

TCI Chemical

Product number: B3881
Product name: 2-Bromo-5-hydroxypyrazine
Purity: >95.0%(GC)
Packaging: 1g
Price: $525
Updated: 2024/03/01

TCI Chemical

Product number: B3881
Product name: 2-Bromo-5-hydroxypyrazine
Purity: >95.0%(GC)
Packaging: 200mg
Price: $153
Updated: 2024/03/01

TRC

Product number: B686183
Product name: 5-Bromo-1H-pyrazin-2-one
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 072250
Product name: 2-Bromo-5-hydroxypyrazine
Purity: 95+%
Packaging: 5g
Price: $69
Updated: 2021/12/16

More

Less

2-Bromo-5-hydroxypyrazine Chemical Properties,Usage,Production

Uses

5-bromo-1H-pyrazin-2-one is a useful research chemical.

Synthesis

59489-71-3

374063-92-0

General procedure for the synthesis of 2-bromo-5-hydroxypyrazine from 2-amino-5-bromopyrazine: sodium nitrite (1.35 g, 19.53 mmol) was added to concentrated sulfuric acid (9.8 mL) in batches at 0 °C. The mixture was heated to 50 °C until the sodium nitrite was completely dissolved and subsequently cooled to 0 °C. A solution of 5-bromo-pyrazin-2-ylamine (2.57 g, 14.68 mmol) in concentrated sulfuric acid (14.7 mL) was added slowly and dropwise. The ice bath was removed and the mixture was gradually warmed to room temperature and stirred for 15 minutes, followed by heating to 45 °C for 7 minutes. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into crushed ice water (100 mL). The pH of the aqueous phase was adjusted to 4 with 20% aqueous sodium hydroxide, followed by extraction with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with water (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give 2-bromo-5-hydroxypyrazine (1.88 g, 73% yield) as a yellow solid. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 8.07 (1H, s), 7.62 (1H, d, J=3.0 Hz).

References

[1] Patent: US2005/187266, 2005, A1
[2] Patent: WO2004/92145, 2004, A1. Location in patent: Page 133
[3] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[4] Patent: US2005/9838, 2005, A1. Location in patent: Page 150
[5] Journal of Chemical Research, 2005, # 11, p. 747 - 749

2-Bromo-5-hydroxypyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Bromo-5-hydroxypyrazine Suppliers

Americas 1 China 198 Czech Republic 1 Europe 1 Germany 2 Hungary 1 India 9 Japan 1 United Kingdom 4 United States 27 Global 245

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

API Intermediates

Tel: --
Fax: --
Email: sales@apiintermediates.com
Country: United States
ProdList: 57
Advantage: 50

Alichem Inc.

Tel: --
Fax: --
Email: sales@alichem.com
Country: United States
ProdList: 6167
Advantage: 58

Chemphtec Corporation

Tel: --
Fax: --
Email: fo@chemphtec.com
Country: United States
ProdList: 2181
Advantage: 58

Apex Scientific Inc.

Tel: --
Fax: --
Email: apex_sci@att.net
Country: United States
ProdList: 188
Advantage: 0

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynChem，Inc

Tel: --
Fax: --
Email: sales@synchem.com
Country: United States
ProdList: 4697
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Synchem Inc.

Tel: --
Fax: --
Email: catalog@synchem.com
Country: United States
ProdList: 1154
Advantage: 46

Fragmenta

Tel: --
Fax: --
Email: sales@fragmenta.com
Country: United States
ProdList: 1068
Advantage: 0

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

TimTec Corporation

Tel: --
Fax: --
Country: United States
ProdList: 1945
Advantage: 58

More

Less

View Lastest Price from 2-Bromo-5-hydroxypyrazine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Bromopyrazin-2-ol 374063-92-0
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Bromo-5-hydroxypyrazine 374063-92-0
Price: US $10.00/KG
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Bromo-5-hydroxypyrazine 374063-92-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

374063-92-0, 2-Bromo-5-hydroxypyrazineRelated Search:

3-Bromoanisole 2-HYDROXYPYRAZINE Mestinon Pyrazinamide Glipizide Sulfachoropyrazine sodium Bromine 2-BROMO-5-METHOXYPYRAZINE 3,5-Dibromo-2-hydroxypyrazine 2-BROMO-5-ETHOXYPYRAZINE 2-BROMO-5-PHENOXYPYRAZINE 2-BROMO-5-(2-DIETHYLAMINOETHOXY)PYRAZINE METHYL 6-BROMO-3-METHOXYPYRAZINE-2-CARBOXYLATE 2-Bromo-5-hydroxypyrazine 2-BROMO-5-(2-DIMETHYLAMINOETHOXY)PYRAZINE 2-BROMO-5-(BENZYLOXY)PYRAZINE 4-(5-BROMO-6-CHLORO-PYRAZIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-BROMO-3,6-DIETHYL-5-(1-ETHYLPROPOXY)PYRAZINE

5-BROMO-2-PYRAZINOL

5-BROMO-2-HYDROXYPYRAZINE

5-BROMO-2-HYDROXYPYRAZINE,5-BROMO-2-PYRAZINOL

5-bromopyrazin-2-ol

5-bromopyrazin-2-o

2(1H)-Pyrazinone, 5-bromo- 2-Bromo-5-hydroxypyrazine

5-Bromopyrazin-2(1H)-one

2-hydroxy-5-bromopyrazine

5-Bromopyrazin-2-ol, 2-Bromo-5-hydroxy-1,4-diazine

2-BROMO-5-HYDROXY-PYRAZINE

5-bromo-1H-pyrazin-2-one

5-Bromopyrazin-2

2-BroMo-5-hydroxypyrazine, 97+%

2-Bromo-5-hydroxypyrazine&gt

2(1H)-Pyrazinone, 5-bromo-

5-Bromo-2(1H)-pyrazinone

2-Bromo-5-hydroxypyrazine ISO 9001：2015 REACH

5-bromopyrazin-2-ol, 98%min

374063-92-0

C4H3N2OBr

C4H3BrN20

Piperazine series

Building Blocks

Pyrazine

Building Blocks/Intermediates