GSK1324726A (I-BET726)

ChemicalBook > CAS DataBase List > GSK1324726A (I-BET726)

Product Name: GSK1324726A (I-BET726)
CAS No.: 1300031-52-0
Chemical Name: GSK1324726A (I-BET726)
Synonyms: GSK1324726A;CS-1736;I-BET726;I-BET726; I-BET 726;GSK1324726A (I-BET726);I-BET726 (GSK1324726A);GSK1324726A (I-BET726) USP/EP/BP;GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit;4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid;4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
CBNumber: CB62677051
Molecular Formula: C25H23ClN2O3
Formula Weight: 434.91
MOL File: 1300031-52-0.mol

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GSK1324726A (I-BET726) Property

Boiling point:: 707.3±60.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥1.87 mg/mL in EtOH with gentle warming and ultrasonic; ≥17.7 mg/mL in DMSO
form: Powder
pka: 4.20±0.10(Predicted)
color: White to light yellow
InChI: InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
InChIKey: FAWSUKOIROHXAP-NPMXOYFQSA-N
SMILES: C(O)(=O)C1=CC=C(C2C=CC3=C(C=2)[C@H](NC2=CC=C(Cl)C=C2)C[C@H](C)N3C(C)=O)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16872
Product name: I-BET726
Purity: ≥98%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 16872
Product name: I-BET726
Purity: ≥98%
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 16872
Product name: I-BET726
Purity: ≥98%
Packaging: 10mg
Price: $263
Updated: 2024/03/01

Cayman Chemical

Product number: 16872
Product name: I-BET726
Purity: ≥98%
Packaging: 25mg
Price: $601
Updated: 2024/03/01

ApexBio Technology

Product number: B1013
Product name: GSK1324726A
Packaging: 1unit
Price: $28
Updated: 2021/12/16

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GSK1324726A (I-BET726) Chemical Properties,Usage,Production

Description

I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC₅₀s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs. I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling. I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.

target

BRD2

References

[1] wyce a, ganji g, smitheman kn, chung cw, korenchuk s, bai y, barbash o, le b, craggs pd, mccabe mt, kennedy-wilson km, sanchez lv, gosmini rl, parr n, mchugh cf, dhanak d, prinjha rk, auger kr, tummino pj. bet inhibition silences expression of mycn and bcl2 and induces cytotoxicity in neuroblastoma tumor models. plos one. 2013 aug 23;8(8):e72967.

GSK1324726A (I-BET726) Preparation Products And Raw materials

Raw materials

Preparation Products

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1300031-52-0, GSK1324726A (I-BET726)Related Search:

I-BET151 (GSK1210151A) Bortezomib CPI-203 OTX015 Nutlin 3a AZD-1208

4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid

I-BET726; I-BET 726

CS-1736

4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid

GSK1324726A

4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl]benzoic acid

GSK1324726A (I-BET726)

4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]benzoic acid

I-BET726

Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-

GSK1324726A (I-BET726) USP/EP/BP

GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit

I-BET726 (GSK1324726A)

1300031-52-0

Inhibitors