GSK1324726A (I-BET726)
- Product Name
- GSK1324726A (I-BET726)
- CAS No.
- 1300031-52-0
- Chemical Name
- GSK1324726A (I-BET726)
- Synonyms
- GSK1324726A;CS-1736;I-BET726;I-BET726; I-BET 726;GSK1324726A (I-BET726);I-BET726 (GSK1324726A);GSK1324726A (I-BET726) USP/EP/BP;GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit;4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid;4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
- CBNumber
- CB62677051
- Molecular Formula
- C25H23ClN2O3
- Formula Weight
- 434.91
- MOL File
- 1300031-52-0.mol
GSK1324726A (I-BET726) Property
- Boiling point:
- 707.3±60.0 °C(Predicted)
- Density
- 1.304±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥1.87 mg/mL in EtOH with gentle warming and ultrasonic; ≥17.7 mg/mL in DMSO
- form
- Powder
- pka
- 4.20±0.10(Predicted)
- InChI
- InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
- InChIKey
- FAWSUKOIROHXAP-NPMXOYFQSA-N
- SMILES
- C(O)(=O)C1=CC=C(C2C=CC3=C(C=2)[C@H](NC2=CC=C(Cl)C=C2)C[C@H](C)N3C(C)=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16872
- Product name
- I-BET726
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 16872
- Product name
- I-BET726
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 16872
- Product name
- I-BET726
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- 16872
- Product name
- I-BET726
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $601
- Updated
- 2024/03/01
- Product number
- B1013
- Product name
- GSK1324726A
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
GSK1324726A (I-BET726) Chemical Properties,Usage,Production
Description
I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs. I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling. I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.
target
BRD2
References
[1] wyce a, ganji g, smitheman kn, chung cw, korenchuk s, bai y, barbash o, le b, craggs pd, mccabe mt, kennedy-wilson km, sanchez lv, gosmini rl, parr n, mchugh cf, dhanak d, prinjha rk, auger kr, tummino pj. bet inhibition silences expression of mycn and bcl2 and induces cytotoxicity in neuroblastoma tumor models. plos one. 2013 aug 23;8(8):e72967.