5-Bromo-2-hydroxybenzyl alcohol
- Product Name
- 5-Bromo-2-hydroxybenzyl alcohol
- CAS No.
- 2316-64-5
- Chemical Name
- 5-Bromo-2-hydroxybenzyl alcohol
- Synonyms
- BROMOSALIGENIN;5-BROMOSALIGENIN;RARECHEM AL BD 0040;5-BROMOSALICYL ALCOHOL;2-HYDROXYMETHYL-4-BROMOPHENOL;4-BROMO-2-HYDROXYMETHYLPHENOL;5-BROMO-2-HYDROXYBENZYL ALCOHOL;5-Bromo-2-hydroxybenzenemethanol;5-BROMO-2-HYDROXYBENZYL ALCOHOL 98%;5-Bromo-2-hydroxybenzyl Alcohol >
- CBNumber
- CB6268796
- Molecular Formula
- C7H7BrO2
- Formula Weight
- 203.03
- MOL File
- 2316-64-5.mol
5-Bromo-2-hydroxybenzyl alcohol Property
- Melting point:
- 110-112 °C (lit.)
- Boiling point:
- 281.8±10.0 °C(Predicted)
- Density
- 1.5178 (rough estimate)
- refractive index
- 1.4620 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- water: soluble0.7% at 25°C(lit.)
- form
- Crystalline Powder or Flakes
- pka
- 9.36±0.18(Predicted)
- color
- White to light brown
- Water Solubility
- water: soluble 0.7% at25°C(lit.)
olive oil: soluble 4.8%(lit.)
alcohol: freely soluble(lit.)
benzene: moderately soluble(lit.)
chloroform: moderately soluble(lit.)
diethyl ether: freely soluble(lit.)
ethyl acetate: freely soluble(lit.)
hot water: soluble(lit.) - BRN
- 509726
- InChIKey
- KNKRHSVKIORZQB-UHFFFAOYSA-N
- CAS DataBase Reference
- 2316-64-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29081990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 197009
- Product name
- 5-Bromo-2-hydroxybenzyl alcohol
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $163
- Updated
- 2025/07/31
- Product number
- B2164
- Product name
- 5-Bromo-2-hydroxybenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- B2164
- Product name
- 5-Bromo-2-hydroxybenzyl Alcohol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- B696165
- Product name
- 5-Bromo-2-hydroxybenzyl Alcohol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B696165
- Product name
- 5-Bromo-2-hydroxybenzyl Alcohol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
5-Bromo-2-hydroxybenzyl alcohol Chemical Properties,Usage,Production
Chemical Properties
white to light brown crystalline powder or flakes
Uses
5-Bromo-2-hydroxybenzyl alcohol was used in the synthesis of:
- 7-bromo-2,3-diphenyl-5H-imidazo[2,1-b][1,3]benzoxazine
- 6-bromo-2-octyl-4H-1,3,2-benzodioxaphosphorin 2-oxide
- 4-bromo-2-(5-iodo-1H-indol-3-ylmethyl)- phenol
Synthesis
1761-61-1
2316-64-5
The general procedure for the synthesis of 5-bromo-2-hydroxybenzenemethanol from 5-bromosalicylaldehyde was as follows: according to the improved synthetic method reported in the literature, 5-bromo-2-hydroxybenzenecarboxaldehyde (10.1 g, 50 mmol) was first dissolved in 250 mL of ethanol at 0 °C. Subsequently, NaBH4 (1.88 g, 50 mmol) was added to the stirring solution in batches (0.3 g each). The reaction mixture was stirred continuously for 18 hours at room temperature. Upon completion of the reaction, ethanol was evaporated under reduced pressure conditions (102 mbar) and the light yellow solid obtained was dissolved in 200 mL of saturated aqueous NH4Cl solution. The crude product was extracted by ether (three times, 80 mL each). The combined organic phases were washed with brine (three times, 20 mL each) and dried with MgSO4 for 2 hours. After drying, the MgSO4 was removed by filtration and the excess solvent was evaporated under reduced pressure (102 mbar). The product was purified by fast chromatography on a silica gel column with hexane/ethyl acetate (8:2, v/v) as eluent. Eventually, evaporation of the solvent gave a colorless solid product (8.52 g, 84% yield).
References
[1] Tetrahedron Asymmetry, 2011, vol. 22, # 13, p. 1395 - 1399
[2] Journal of Chemical Research - Part S, 2003, # 6, p. 335 - 339
[3] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2003, vol. 58, # 12, p. 1220 - 1226
[4] Bulletin of the Chemical Society of Japan, 2005, vol. 78, # 2, p. 307 - 315
[5] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005, vol. 60, # 4, p. 453 - 457
5-Bromo-2-hydroxybenzyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-hydroxybenzyl alcohol manufacturers
- Product
- 5-Bromo-2-hydroxybenzyl alcohol 2316-64-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24