5-Bromo-2-hydroxybenzyl alcohol

5-Bromo-2-hydroxybenzyl alcohol Property

Melting point:

110-112 °C (lit.)

Boiling point:

281.8±10.0 °C(Predicted)

Density 

1.5178 (rough estimate)

refractive index 

1.4620 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

water: soluble0.7% at 25°C(lit.)

form 

Crystalline Powder or Flakes

pka

9.36±0.18(Predicted)

color 

White to light brown

Water Solubility 

water: soluble 0.7% at25°C(lit.)
olive oil: soluble 4.8%(lit.)
alcohol: freely soluble(lit.)
benzene: moderately soluble(lit.)
chloroform: moderately soluble(lit.)
diethyl ether: freely soluble(lit.)
ethyl acetate: freely soluble(lit.)
hot water: soluble(lit.)

BRN 

509726

InChIKey

KNKRHSVKIORZQB-UHFFFAOYSA-N

CAS DataBase Reference

2316-64-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29081990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-Bromo-2-hydroxybenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

white to light brown crystalline powder or flakes

Uses

5-Bromo-2-hydroxybenzyl alcohol was used in the synthesis of:

• 7-bromo-2,3-diphenyl-5H-imidazo[2,1-b][1,3]benzoxazine
• 6-bromo-2-octyl-4H-1,3,2-benzodioxaphosphorin 2-oxide
• 4-bromo-2-(5-iodo-1H-indol-3-ylmethyl)- phenol

Synthesis

The general procedure for the synthesis of 5-bromo-2-hydroxybenzenemethanol from 5-bromosalicylaldehyde was as follows: according to the improved synthetic method reported in the literature, 5-bromo-2-hydroxybenzenecarboxaldehyde (10.1 g, 50 mmol) was first dissolved in 250 mL of ethanol at 0 °C. Subsequently, NaBH4 (1.88 g, 50 mmol) was added to the stirring solution in batches (0.3 g each). The reaction mixture was stirred continuously for 18 hours at room temperature. Upon completion of the reaction, ethanol was evaporated under reduced pressure conditions (102 mbar) and the light yellow solid obtained was dissolved in 200 mL of saturated aqueous NH4Cl solution. The crude product was extracted by ether (three times, 80 mL each). The combined organic phases were washed with brine (three times, 20 mL each) and dried with MgSO4 for 2 hours. After drying, the MgSO4 was removed by filtration and the excess solvent was evaporated under reduced pressure (102 mbar). The product was purified by fast chromatography on a silica gel column with hexane/ethyl acetate (8:2, v/v) as eluent. Eventually, evaporation of the solvent gave a colorless solid product (8.52 g, 84% yield).

References

[1] Tetrahedron Asymmetry, 2011, vol. 22, # 13, p. 1395 - 1399
[2] Journal of Chemical Research - Part S, 2003, # 6, p. 335 - 339
[3] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2003, vol. 58, # 12, p. 1220 - 1226
[4] Bulletin of the Chemical Society of Japan, 2005, vol. 78, # 2, p. 307 - 315
[5] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005, vol. 60, # 4, p. 453 - 457