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Methotrexate γ-Methyl Ester

Product Name
Methotrexate γ-Methyl Ester
CAS No.
67022-39-3
Chemical Name
Methotrexate γ-Methyl Ester
Synonyms
Methotrexate Impurity H;Methotrexate EP Impurity H;Methotrexate γ-Methyl Ester;Methotrexate γ-Methyl Ester;Methotrexate Impurity 8(EP-H);Methotrexate-5-monomethyl ester;Methotrexate Related Compound H;Methotrexate gamma-Methyl Ester;Methotrexate USP Related Compound H;Methotrexate-Methyl Ester (TEA salt)
CBNumber
CB62695972
Molecular Formula
C21H24N8O5
Formula Weight
468.47
MOL File
67022-39-3.mol
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Methotrexate γ-Methyl Ester Property

Melting point:
170-174 °C
Density 
1.459±0.06 g/cm3(Predicted)
solubility 
Aqueous Base (Slightly, Sonicated), DMSO (Slightly, Heated)
pka
3.43±0.10(Predicted)
form 
Solid
color 
Light Yellow to Orange
Stability:
Hygroscopic
InChIKey
RYGFOBBTCUXHBB-WDHUHKLTNA-N
SMILES
NC1=NC(N)=NC2=NC=C(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)OC)=CC=3)C)N=C12 |&1:19,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
M260705
Product name
Methotrexateγ-MethylEster
Packaging
500mg
Price
$1455
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
52130
Product name
Methotrexateγ-MethylEster
Packaging
1g
Price
$2200
Updated
2021/12/16
Biosynth Carbosynth
Product number
IM71453
Product name
Methotrexate-5-monomethyl ester
Packaging
10mg
Price
$650
Updated
2021/12/16
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Methotrexate γ-Methyl Ester Chemical Properties,Usage,Production

Uses

Methotrexate γ-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.

Methotrexate γ-Methyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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67022-39-3, Methotrexate γ-Methyl EsterRelated Search:

N-(p-Aminobenzoyl)glutamic acid Aminopterin methotrexate-gamma-dimethylamide D(-)-AMETHOPTERIN Methotrexate impurity 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE METHOTREXATE DIMETHYL ESTER Methotrexate α-Methyl Ester L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]- L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- Folic Acid Related Compound A/Calcium Formyltetrahydrofolate METHOTREXATE-D3 N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID L-Glutamic acid der. 7-HYDROXY METHOTREXATE 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Methotrexate Related Compound E (50 mg) (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, hemihydrochloride) 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID

  • Methotrexate EP Impurity H
  • Methotrexate Impurity 8(EP-H)
  • Methotrexate EP Impurity H (Methotrexate-5-Monomethyl Ester)
  • Methotrexate-5-monomethyl ester
  • Methotrexate EP Impurity H（Amethopterin EP Impurity H）
  • Methotrexate γ-Methyl Ester (Impurity H)
  • (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid
  • Methotrexate Impurity H
  • L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 5-methyl ester
  • Methotrexate Impurity 8（Methotrexate EP Impurity H）
  • (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-methoxy-5-oxopentanoic acid
  • Methotrexate EP Impurity H (Methotrexate 5-Methyl Ester)
  • Methotrexate-Methyl Ester (TEA salt)
  • Methotrexate Related Compound H
  • Methotrexate USP Related Compound H
  • Methotrexate gamma-Methyl Ester
  • Methotrexate γ-Methyl Ester
  • (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic Ac
  • Methotrexate γ-Methyl Ester, CAS 67022-39-3
  • Methotrexate γ-Methyl Ester
  • (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic Acid (Methotrexate 5-Methyl Ester)
  • 67022-39-3
  • Aromatics, Chiral Reagents, Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals