4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

Product Name: 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid
CAS No.: 5623-18-7
Chemical Name: 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid
Synonyms: Metfol-B;NSC 408937;Methotrexate-EP-Imp-D;N10-Methyl Pteroic Acid;Methotrexate EP Impurity D;Methotrexate Impurity 4(EP-D);Methotrexate Impurity 4（Methotrexate EP Impurity D）;Methotrexate EP Impurity D（Amethopterin EP Impurity D）;4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino}benzoic acid;p-[(2-Amino-4-hydroxy-6-pteridinyl)methyl(methyl)amino]benzoic acid
CBNumber: CB02262484
Molecular Formula: C15H14N6O3
Formula Weight: 326.31
MOL File: 5623-18-7.mol

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4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Property

Melting point:: >245°C (dec.)
Boiling point:: 583.7±60.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Aqueous Base (Slightly), DMSO (Very Slightly, Heated), Methanol (Very Slightly)
pka: 4.74±0.10(Predicted)
color: Orange to Red
Major Application: pharmaceutical (small molecule)
InChI: 1S/C15H14N6O3/c1-21(10-4-2-8(3-5-10)14(23)24)7-9-6-17-12-11(18-9)13(22)20-15(16)19-12/h2-6H,7H2,1H3,(H,23,24)(H3,16,17,19,20,22)
InChIKey: QHNLFEQJGRZKTK-UHFFFAOYSA-N
SMILES: [nH]1c2nc(n[c](c2nc(c1)CN(C)c3ccc(cc3)C(=O)O)=O)N

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M1000008
Product name: Methotrexate impurity D
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $254
Updated: 2026/03/19

Sigma-Aldrich

Product number: M1000008
Product name: Methotrexate impurity D
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: m1000008
Price: $220
Updated: 2024/03/01

TRC

Product number: M326265
Product name: N10-MethylPteroicAcid
Packaging: 25mg
Price: $105
Updated: 2021/12/16

TRC

Product number: M326265
Product name: N10-MethylPteroicAcid
Packaging: 250mg
Price: $810
Updated: 2021/12/16

TRC

Product number: M326265
Product name: N10-MethylPteroicAcid
Packaging: 500mg
Price: $1455
Updated: 2021/12/16

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4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Chemical Properties,Usage,Production

Chemical Properties

Dark Orange Solid

Uses

N10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.

Uses

Methotrexate (M260675) impurity D.

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Suppliers

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5623-18-7, 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acidRelated Search:

7-HYDROXY METHOTREXATE METHOTREXATE DIMETHYL ESTER Methotrexate Related Compound E (50 mg) (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, hemihydrochloride) Methotrexate γ-Methyl Ester Methotrexate α-Methyl Ester METHOTREXATE-D3 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID Methotrexate L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- methotrexate-gamma-dimethylamide N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Aminopterin Methotrexate EP Impurity G D(-)-AMETHOPTERIN L-Glutamic acid der. Folic Acid Related Compound A/Calcium Formyltetrahydrofolate

p-[(2-Amino-4-hydroxy-6-pteridinyl)methyl(methyl)amino]benzoic acid

N10-Methyl Pteroic Acid

4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoic Acid

Metfol-B

NSC 408937

4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino}benzoic acid

Methotrexate EP Impurity D

Methotrexate Impurity 4(EP-D)

Methotrexate EP Impurity D/N10-Methylpteroic acid/4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoic acid

Methotrexate EP Impurity D（Amethopterin EP Impurity D）

Methotrexate-EP-Imp-D

4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzoic acid

Benzoic acid, 4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]-

Methotrexate Impurity 4（Methotrexate EP Impurity D）

4-(((2-Amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)(methyl)amino)benzoic acid (Methotrexate Impurity)

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

5623-18-7

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