6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

Product Name: 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
CAS No.: 52853-40-4
Chemical Name: 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Synonyms: 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide;2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide;Nsc253943;Methotrexate Impurity 15;Methotrexate Impurity 16;Methotrexate Impurity 17 HBr;6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR;2, 4-diaMino-6-(broMoMethyl)-pteridine HCL;6-Bromomethyl-pteridine-2,4-diamine hydrobromide;2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
CBNumber: CB51010881
Molecular Formula: C7H8Br2N6
Formula Weight: 335.99
MOL File: 52853-40-4.mol

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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Property

Melting point:: >195°C (dec.)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Light Brown to Brown
InChI: InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
InChIKey: KMQIBGKVZDBGAH-UHFFFAOYSA-N
SMILES: NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B685475
Product name: 6-(Bromomethyl)-2,4-pteridinediamineHydrobromide(TechnicalGrade)
Packaging: 5g
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: Z3606
Product name: 6-Bromomethyl-pteridine-2,4-diamineHBr
Packaging: 10g
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19250
Product name: 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide (technical grade)
Packaging: 50g
Price: $250
Updated: 2021/12/16

Matrix Scientific

Product number: 093056
Product name: 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Purity: tech.
Packaging: 250mg
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 093056
Product name: 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Purity: tech.
Packaging: 50050g
Price: $33
Updated: 2021/12/16

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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Chemical Properties,Usage,Production

Description

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.

Chemical Properties

Light Brown Solid

Uses

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

Application

6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Preparation Products And Raw materials

Raw materials

Sodium acetate Ethanol 1,3-Dihydroxyacetone Hydrogen bromide Diethyl ether L-Cysteine Government regulation Acetic acid Pyrimidinetetramine sulfate Barium chloride Triphenylphosphine N,N-Dimethylacetamide Activated carbon Barium sulfate

Preparation Products

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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Suppliers

Canada 1 China 145 Germany 1 India 4 United Kingdom 1 United States 8 Global 160

FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd

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YUANSHU PHARMACEUTICAL TECHNOLOGY CO.,LTD

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T&W GROUP

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Hangzhou Sage Chemical Co., Ltd.

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View Lastest Price from 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide 52853-40-4
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 90%min
Supply Ability: 100KGS
Release date: 2021-07-07

Career Henan Chemical Co

Product: 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR 52853-40-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1tons
Release date: 2018-08-08

52853-40-4, 6-(Bromomethyl)-2,4-pteridinediamine hydrobromideRelated Search:

1-Bromo-2-methoxyethane Aminopterin 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- Methotrexate 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Hydroxyethyl starch Pyrazine, (bromomethyl)- (9CI) 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide

2, 4-diaMino-6-(broMoMethyl)-pteridine HCL

2,4-diamino-6-(bromomethyl)pteridine(for methotrexate)

6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR

2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide

6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide

2,4-PteridinediaMine, 6-(broMoMethyl)-, MonohydrobroMide

6-(BroMoMethyl)-2,4-pteridinediaMine HydrobroMide (Technical Grade)

Nsc253943

6-Bromomethyl-pteridine-2,4-diamine hydrobromide

2,4-PteridinediaMine, 6-(broMoMethyl)-, hydrobroMide (1:1)

6-(Bromomethyl)-2,4-pteridinediamine hydrochloride

6-(Bromomethyl)pteridine-2,4-diamine hydrobromide (1:1)

Methotrexate Impurity 15

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide, tech grade

Methotrexate Impurity 16

6-Bromomethyl-pteridine-2,4-diamine hbrQ: What is 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the CAS Number of 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the storage condition of 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What are the applications of 6-Bromomethyl-pteridine-2,4-diamine hbr

Methotrexate Impurity 17 HBr

6-(bromomethyl)-2,4-Pteridinediamine hydrobromide (1:1)

52853-40-4

C7H72N6HBr

C7H8Br2N6

BrHC7H7BrN6

C7H7BrN6BrH

Aromatics

Bases & Related Reagents

Inhibitors

Nucleotides

Aromatics Compounds