ChemicalBook > CAS DataBase List > 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

Product Name
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
CAS No.
52853-40-4
Chemical Name
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Synonyms
6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide;2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide;Nsc253943;Methotrexate Impurity 15;Methotrexate Impurity 16;Methotrexate Impurity 17 HBr;6-Bromoethyl-pteridine-2,4-diamine;6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR;2, 4-diaMino-6-(broMoMethyl)-pteridine HCL;6-Bromomethyl-pteridine-2,4-diamine hydrobromide
CBNumber
CB51010881
Molecular Formula
C7H8Br2N6
Formula Weight
335.99
MOL File
52853-40-4.mol
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Property

Melting point:
>195°C (dec.)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Light Brown to Brown
InChI
InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
InChIKey
KMQIBGKVZDBGAH-UHFFFAOYSA-N
SMILES
NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B685475
Product name
6-(Bromomethyl)-2,4-pteridinediamineHydrobromide(TechnicalGrade)
Packaging
5g
Price
$155
Updated
2021/12/16
AK Scientific
Product number
Z3606
Product name
6-Bromomethyl-pteridine-2,4-diamineHBr
Packaging
10g
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB19250
Product name
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide (technical grade)
Packaging
50g
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
093056
Product name
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Purity
tech.
Packaging
250mg
Price
$21
Updated
2021/12/16
Matrix Scientific
Product number
093056
Product name
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Purity
tech.
Packaging
50050g
Price
$33
Updated
2021/12/16
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Chemical Properties,Usage,Production

Description

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.

Chemical Properties

Light Brown Solid

Uses

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

Application

6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Preparation Products And Raw materials

Raw materials

Sodium acetate Ethanol 1,3-Dihydroxyacetone Hydrogen bromide Diethyl ether L-Cysteine Bromine Acetic acid Pyrimidinetetramine sulfate Barium chloride Triphenylphosphine N,N-Dimethylacetamide Activated carbon Barium sulfate

Preparation Products

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View Lastest Price from 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide 52853-40-4
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
90%min
Supply Ability
100KGS
Release date
2021-07-07
Career Henan Chemical Co
Product
6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR 52853-40-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1tons
Release date
2018-08-08

52853-40-4, 6-(Bromomethyl)-2,4-pteridinediamine hydrobromideRelated Search:

1-Bromo-2-methoxyethane Aminopterin 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- Methotrexate 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Hydroxyethyl starch Pyrazine, (bromomethyl)- (9CI) 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

  • 2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide
  • 2, 4-diaMino-6-(broMoMethyl)-pteridine HCL
  • 2,4-diamino-6-(bromomethyl)pteridine(for methotrexate)
  • 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
  • 2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
  • 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide
  • 2,4-PteridinediaMine, 6-(broMoMethyl)-, MonohydrobroMide
  • 6-(BroMoMethyl)-2,4-pteridinediaMine HydrobroMide (Technical Grade)
  • Nsc253943
  • 6-Bromomethyl-pteridine-2,4-diamine hydrobromide
  • 2,4-PteridinediaMine, 6-(broMoMethyl)-, hydrobroMide (1:1)
  • 6-(Bromomethyl)-2,4-pteridinediamine hydrochloride
  • 6-(Bromomethyl)pteridine-2,4-diamine hydrobromide (1:1)
  • Methotrexate Impurity 15
  • 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide, tech grade
  • Methotrexate Impurity 16
  • 6-Bromomethyl-pteridine-2,4-diamine hbrQ: What is 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the CAS Number of 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What is the storage condition of 6-Bromomethyl-pteridine-2,4-diamine hbr Q: What are the applications of 6-Bromomethyl-pteridine-2,4-diamine hbr
  • Methotrexate Impurity 17 HBr
  • 6-(bromomethyl)-2,4-Pteridinediamine hydrobromide (1:1)
  • 6-Bromoethyl-pteridine-2,4-diamine
  • 52853-40-4
  • C7H72N6HBr
  • C7H8Br2N6
  • BrHC7H7BrN6
  • C7H7BrN6BrH
  • Aromatics
  • Bases & Related Reagents
  • Inhibitors
  • Nucleotides
  • Aromatics Compounds