Pyrimidinetetramine sulfate

Product Name: Pyrimidinetetramine sulfate
CAS No.: 5392-28-9
Chemical Name: Pyrimidinetetramine sulfate
Synonyms: 2,4,5,6-Tetraaminopyrimidine sulfate;2,4,5,6-TETRAAMINIOPYRIMIDINE SULFATE;5329-28-9;TETRAAMINOPYRIMIDINE SULFATE;2,4,5,6-Tetramino Pyridine Sulfate;PyriMidine-2,4,5,6-tetraaMine sulfate;NSC 3277;NSC 227862;Hc Red 16;JACS-5392-28-9
CBNumber: CB8170253
Molecular Formula: C4H10N6O4S
Formula Weight: 238.22
MOL File: 5392-28-9.mol

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Pyrimidinetetramine sulfate Property

Melting point:: >300 °C(lit.)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Water (Very Slightly, Heated)
form: Crystalline Powder
color: Ochre to brown
Water Solubility: slightly soluble
BRN: 3785189
Cosmetics Ingredients Functions: HAIR DYEING
InChI: InChI=1S/C4H8N6.H2O4S/c5-1-2(6)9-4(8)10-3(1)7;1-5(2,3)4/h5H2,(H6,6,7,8,9,10);(H2,1,2,3,4)
InChIKey: MQEFDQWUCTUJCP-UHFFFAOYSA-N
SMILES: NC1=C(N=C(N)N=C1N)N.S(O)(O)(=O)=O
CAS DataBase Reference: 5392-28-9(CAS DataBase Reference)
EPA Substance Registry System: Pyrimidinetetramine, sulfate (1:1) (5392-28-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26-36
WGK Germany: 3
RTECS: UV9738000
TSCA: TSCA listed
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3807
Product name: 2,4,5,6-Tetraaminopyrimidine sulfate salt
Purity: 97%
Packaging: 25g
Price: $48.2
Updated: 2025/07/31

TCI Chemical

Product number: T1462
Product name: 2,4,5,6-Tetraaminopyrimidine Sulfate
Purity: >98.0%(T)
Packaging: 25g
Price: $165
Updated: 2025/07/31

TRC

Product number: T283940
Product name: 2,4,5,6-Tetraaminopyrimidine Sulfate
Packaging: 100g
Price: $185
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK190473
Product name: 2,4,5,6-Tetraaminopyrimidine Sulfate
Purity: 98%
Packaging: 5g
Price: $15
Updated: 2021/12/16

AK Scientific

Product number: D255
Product name: 2,4,5,6-Tetraaminopyrimidine Sulfate
Packaging: 25g
Price: $27
Updated: 2021/12/16

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Pyrimidinetetramine sulfate Chemical Properties,Usage,Production

Chemical Properties

Light yellow crystal powder

Uses

2,4,5,6-Tetraaminopyrimidine Sulfate is an intermediate for the synthesis of the antitumor drugs methotrexate and fludarabine.

Synthesis

Pyrimidinetetramine sulfate is synthesized from malononitrile and guanidine nitrate through a three-step reaction involving cyclization, nitrosation, and reduction. This process uses zinc powder instead of the expensive reducing agent Raney nickel, resulting in lower costs, simpler operation, and greater safety and environmental friendliness.

Purification Methods

Purify the salt by recrystallisation from H2O, 2N H2SO4 (20 parts, 67% recovery) or 0.1N H2SO4 (40 parts, 62% recovery), and dried in air. [UV: Konrad & Pfleiderer Chem Ber 103 722 1970, Malletta et al. J Am Chem Soc 69 1814 1947, Cavalieri et al. J Am Chem Soc 70 3875 1948, Beilstein 25 H 423, 25 III/IV 3106.]

References

[1] SAUMYA SHUKLA. Toxic potential assessment of hair dye developer 2,4,5,6-tetraaminopyrimidine sulfate exposed under ambient UVB radiation.[J]. Toxicology and Industrial Health, 2024: 1-8. DOI:10.1177/07482337231209352.
[2] https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_152.pdf

Pyrimidinetetramine sulfate Preparation Products And Raw materials

Raw materials

2,4,6-Triaminopyrimidine

Preparation Products

2,4,5,6-TETRAAMINOPYRIMIDINE 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide N10-(TRIFLUOROACETYL)PTEROIC ACID

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Pyrimidinetetramine sulfate Suppliers

Belgium 3 Canada 3 China 391 Czech Republic 1 Europe 2 France 2 Germany 7 India 20 Japan 8 Slovakia 1 South Korea 2 Spain 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 60 Global 525

Liaoning bomei pharmaceutical technology co. LTD.

Tel: 24-24524889 18640309171
Fax: +86-24-24524889
Email: 236415745@qq.com
Country: China
ProdList: 48
Advantage: 58

Ereal Chemical Co., Ltd.

Tel: 0831-6888461 15181138905
Fax: QQ：97273224
Email: sales@erealchem.com
Country: China
ProdList: 84
Advantage: 55

Suzhou Surui Pharmaceutical Chemical Co., Ltd

Tel: 0512-68086196 15051406830
Fax: 0512-68240735
Email: 3228574886@qq.com
Country: China
ProdList: 12
Advantage: 58

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Email: enkepharma@126.com;sale@enkepharma.com
Country: China
ProdList: 2265
Advantage: 55

Panjin Jiahe Shengshi Pharmaceutical Technology Co., Ltd

Tel: 13464671885 13032431717
Email: sale@jhssw.com
Country: China
ProdList: 45
Advantage: 58

Zhenjiang Hongyu Biotechnology Co., Ltd

Tel: 15189105787
Email: 19708301@qq.com
Country: China
ProdList: 29
Advantage: 58

Nanjing Yongyi Pharma Tech Co. , Ltd.

Tel: 13770533061
Email: renqing401@163.com
Country: China
ProdList: 326
Advantage: 58

Shanghai Lankun Pharmaceutical Technology Co., Ltd

Tel: 18616122638
Email: saleslee@kunrising.com
Country: China
ProdList: 29
Advantage: 58

SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 924
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

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View Lastest Price from Pyrimidinetetramine sulfate manufacturers

Asia Chem I and E (Jiangsu) Co Ltd

Product: 2,4,5,6-Tetraaminopyrimidine sulfate 5392-28-9
Price: US $80.00/kgkg
Min. Order: 1kgkg
Purity: 98.0～102.0%
Supply Ability: 10tons/month
Release date: 2025-07-10

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pyrimidinetetramine sulfate 5392-28-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 10 tons
Release date: 2021-07-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: Pyrimidinetetramine sulfate 5392-28-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-04

5392-28-9, Pyrimidinetetramine sulfateRelated Search:

D-Glucosamine sulfate Aluminum sulfate Zinc sulfate heptahydrate SULFATE STANDARD Potassium persulfate Vanadyl sulfate Colistin sulfate Sodium sulfate Magnesium sulfate heptahydrate Ammonium sulfate Magnesium sulfate Barium sulfate Atropine sulfate Copper(II) sulfate SODIUM SULFATE sulfate 4,5,6-Triaminopyrimidine sulfate hydrate 2,4,5-Trifluorobenzonitrile

pyrimidinetetrayltetraamine sulphate

PYRIMIDINE-2,4,5,6-TETRAMINE SULPHATE

2,4,5,6-TETRAAMINIOPYRIMIDINE SULFATE

2,4,5,6-TETRAAMINO-PYRIMIDINE SULFATE SALT

2,4,5,6-Tetraaminopyrimidine sulfate hydrate,98%

2,4,5,6-Tetraaminopyrimidine sulfate

6-TetraaMinopyriMidine sulfate

PyriMidine-2,4,5,6-tetraaMine sulfate

PyriMidine-2,4,5,6-tetraaMine sulfate, 95+%

2,4,5,6-tetraMinopyriMide sulfate

2,4,5,6-TetraaMinopyriMidine sulfate hydrate, 98% 25GR

2,4,5,6-PyriMidinetetraMine Sulfate

NSC 227862

NSC 3277

2,4,5,6-PyriMidinetetraMine, sulfate (1:1)

TAP Tetraaminopyrimidine sulfate

2,4,5,6-Tetraaminopyrimidine sulfate(for methotrexate)

5329-28-9

Pyrimidintetrayltetraaminsulfat

JACS-5392-28-9

2,4,5,6-TETRAAMINOPYRIMIDINE SULPHATE

2,4,5,6-Pyrimidinetetraamine sulfate salt

2,4,5,6-Tetramino Pyridine Sulfate

pyrimidinetetramine sulphate

2,4,5,6-Tetraamino pyrimidine-H2SO4

2,4,5,6-TETRAAMINOPYRIMIDINE SULFATE, 97 %

TETRAAMINOPYRIMIDINE SULFATE

2,4,5,6-Tetraminopyrimidinesulphate

Pyrimidinetetramine, sulfate (1:1)

2,4,5,6-tetraaminopyrimidine sulfate (intermediate of methotrexate)

Pyrimidinetetrayltetraamine sulfate.

2,4,5,6-TETRAAMINOPYRIMIDINESULFATESESQUIHYDRATE

2,4,5,6-TETRAAMINOPYRIMIDINESULFATEHEMIHYDRATE

TETRA-AMINOPYRIMIDINESULPHATE

2,4,5,6-tetroaminopyrimidine sulfate

2,4,5,6-TETRAMINOPYRIMIDINE SULFATE 99+%

2,4,5,6-TETRAAMINOPYRIMIDINE SULFATE 98%

Tetraaminopyrinidine-sulfate taps

2,4,5,6-TETRAAMINOPYRIMIDINE (H2SO4 SALT)

2,4,5,6-Tetraaminopyrimidine hydrate sulfate salt

Pyrimidine-2,4,5,6-tetramine sulfuric acid

2,4,5,6-Tetraaminopyrimidine sulfate hydrate, 98%

2,4,5,6-Teraamino pyrimidine sulfate

Hc Red 16

Pyrimidine-2,4,5,6-tetraamine suL

Pyrimidinetetramine sulfate ISO 9001：2015 REACH

Methotrexate Impurity 22 Sulfate

3',5'-Bis-0-(4-chlorobenzoy1l-2-deoxy-5-azacytosine'

2,4,5,6-Tetraaminopyrimidine sulfate, 95

Methotrexate Impurity 11 Sulfate

5392-28-9

5329-28-9

C4H8N6H2SO4

C4H10N6O4S

C4H8N6H2SO4xH2O

C4H8N6H2O4S

Pyrimidines

Heterocyclic Building Blocks