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Pyrimidinetetramine sulfate

Product Name
Pyrimidinetetramine sulfate
CAS No.
5392-28-9
Chemical Name
Pyrimidinetetramine sulfate
Synonyms
2,4,5,6-Tetraaminopyrimidine sulfate;2,4,5,6-TETRAAMINIOPYRIMIDINE SULFATE;5329-28-9;TETRAAMINOPYRIMIDINE SULFATE;2,4,5,6-Tetramino Pyridine Sulfate;PyriMidine-2,4,5,6-tetraaMine sulfate;NSC 3277;NSC 227862;Hc Red 16;JACS-5392-28-9
CBNumber
CB8170253
Molecular Formula
C4H10N6O4S
Formula Weight
238.22
MOL File
5392-28-9.mol
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Pyrimidinetetramine sulfate Property

Melting point:
>300 °C(lit.)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Water (Very Slightly, Heated)
form 
Crystalline Powder
color 
Ochre to brown
Water Solubility 
slightly soluble
BRN 
3785189
InChIKey
MQEFDQWUCTUJCP-UHFFFAOYSA-N
CAS DataBase Reference
5392-28-9(CAS DataBase Reference)
EPA Substance Registry System
Pyrimidinetetramine, sulfate (1:1) (5392-28-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
RTECS 
UV9738000
TSCA 
Yes
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3807
Product name
2,4,5,6-Tetraaminopyrimidine sulfate salt
Purity
97%
Packaging
25g
Price
$56.2
Updated
2024/03/01
TCI Chemical
Product number
T1462
Product name
2,4,5,6-Tetraaminopyrimidine Sulfate
Purity
>98.0%(T)
Packaging
25g
Price
$165
Updated
2024/03/01
Alfa Aesar
Product number
A18788
Product name
2,4,5,6-Tetraaminopyrimidine sulfate, 97%
Packaging
10g
Price
$23.65
Updated
2024/03/01
Alfa Aesar
Product number
A18788
Product name
2,4,5,6-Tetraaminopyrimidine sulfate, 97%
Packaging
50g
Price
$65.65
Updated
2024/03/01
Alfa Aesar
Product number
A18788
Product name
2,4,5,6-Tetraaminopyrimidine sulfate, 97%
Packaging
250g
Price
$270.65
Updated
2024/03/01
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Pyrimidinetetramine sulfate Chemical Properties,Usage,Production

Chemical Properties

Light yellow crystal powder

Uses

2,4,5,6-Tetraaminopyrimidine Sulfate is an intermediate for the synthesis of the antitumor drugs methotrexate and fludarabine.

Purification Methods

Purify the salt by recrystallisation from H2O, 2N H2SO4 (20 parts, 67% recovery) or 0.1N H2SO4 (40 parts, 62% recovery), and dried in air. [UV: Konrad & Pfleiderer Chem Ber 103 722 1970, Malletta et al. J Am Chem Soc 69 1814 1947, Cavalieri et al. J Am Chem Soc 70 3875 1948, Beilstein 25 H 423, 25 III/IV 3106.]

References

[1] SAUMYA SHUKLA. Toxic potential assessment of hair dye developer 2,4,5,6-tetraaminopyrimidine sulfate exposed under ambient UVB radiation.[J]. Toxicology and Industrial Health, 2024: 1-8. DOI:10.1177/07482337231209352.
[2] https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_152.pdf

Pyrimidinetetramine sulfate Preparation Products And Raw materials

Raw materials

2,4,6-Triaminopyrimidine

Preparation Products

2,4,5,6-TETRAAMINOPYRIMIDINE 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide N10-(TRIFLUOROACETYL)PTEROIC ACID
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Pyrimidinetetramine sulfate Suppliers

Belgium 3 Canada 3 China 369 Czech Republic 1 Europe 2 France 2 Germany 7 India 19 Japan 8 Slovakia 1 South Korea 2 Spain 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 19 United States 61 Global 503
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
Achemica
Tel
--
Fax
--
Email
contact@achemica.com
Country
Switzerland
ProdList
6155
Advantage
50
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from Pyrimidinetetramine sulfate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
2,4,5,6-Tetraaminopyrimidine sulfate 5392-28-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-05-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pyrimidinetetramine sulfate 5392-28-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
10 tons
Release date
2021-07-27
Hebei Weibang Biotechnology Co., Ltd
Product
Pyrimidinetetramine sulfate 5392-28-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-04

5392-28-9, Pyrimidinetetramine sulfateRelated Search:

D-Glucosamine sulfate Aluminum sulfate Zinc sulfate heptahydrate SULFATE STANDARD Potassium persulfate Vanadyl sulfate Colistin sulfate Sodium sulfate Magnesium sulfate heptahydrate Ammonium sulfate Magnesium sulfate Barium sulfate Atropine sulfate Copper(II) sulfate SODIUM SULFATE sulfate 4,5,6-Triaminopyrimidine sulfate hydrate 2,4,5-Trifluorobenzonitrile

  • pyrimidinetetrayltetraamine sulphate
  • PYRIMIDINE-2,4,5,6-TETRAMINE SULPHATE
  • 2,4,5,6-TETRAAMINIOPYRIMIDINE SULFATE
  • 2,4,5,6-TETRAAMINO-PYRIMIDINE SULFATE SALT
  • 2,4,5,6-Tetraaminopyrimidine sulfate hydrate,98%
  • 2,4,5,6-Tetraaminopyrimidine sulfate
  • 6-TetraaMinopyriMidine sulfate
  • PyriMidine-2,4,5,6-tetraaMine sulfate
  • PyriMidine-2,4,5,6-tetraaMine sulfate, 95+%
  • 2,4,5,6-tetraMinopyriMide sulfate
  • 2,4,5,6-TetraaMinopyriMidine sulfate hydrate, 98% 25GR
  • 2,4,5,6-PyriMidinetetraMine Sulfate
  • NSC 227862
  • NSC 3277
  • 2,4,5,6-PyriMidinetetraMine, sulfate (1:1)
  • TAP Tetraaminopyrimidine sulfate
  • 2,4,5,6-Tetraaminopyrimidine sulfate(for methotrexate)
  • 5329-28-9
  • Pyrimidintetrayltetraaminsulfat
  • JACS-5392-28-9
  • 2,4,5,6-TETRAAMINOPYRIMIDINE SULPHATE
  • 2,4,5,6-Pyrimidinetetraamine sulfate salt
  • 2,4,5,6-Tetramino Pyridine Sulfate
  • pyrimidinetetramine sulphate
  • 2,4,5,6-Tetraamino pyrimidine-H2SO4
  • 2,4,5,6-TETRAAMINOPYRIMIDINE SULFATE, 97 %
  • TETRAAMINOPYRIMIDINE SULFATE
  • 2,4,5,6-Tetraminopyrimidinesulphate
  • Pyrimidinetetramine, sulfate (1:1)
  • 2,4,5,6-tetraaminopyrimidine sulfate (intermediate of methotrexate)
  • Pyrimidinetetrayltetraamine sulfate.
  • 2,4,5,6-TETRAAMINOPYRIMIDINESULFATESESQUIHYDRATE
  • 2,4,5,6-TETRAAMINOPYRIMIDINESULFATEHEMIHYDRATE
  • TETRA-AMINOPYRIMIDINESULPHATE
  • 2,4,5,6-tetroaminopyrimidine sulfate
  • 2,4,5,6-TETRAMINOPYRIMIDINE SULFATE 99+%
  • 2,4,5,6-TETRAAMINOPYRIMIDINE SULFATE 98%
  • Tetraaminopyrinidine-sulfate taps
  • 2,4,5,6-TETRAAMINOPYRIMIDINE (H2SO4 SALT)
  • 2,4,5,6-Tetraaminopyrimidine hydrate sulfate salt
  • Pyrimidine-2,4,5,6-tetramine sulfuric acid
  • 2,4,5,6-Tetraaminopyrimidine sulfate hydrate, 98%
  • 2,4,5,6-Teraamino pyrimidine sulfate
  • Hc Red 16
  • Pyrimidine-2,4,5,6-tetraamine suL
  • Pyrimidinetetramine sulfate ISO 9001：2015 REACH
  • Methotrexate Impurity 22 Sulfate
  • 3',5'-Bis-0-(4-chlorobenzoy1l-2-deoxy-5-azacytosine'
  • 2,4,5,6-Tetraaminopyrimidine sulfate, 95
  • Methotrexate Impurity 11 Sulfate
  • 5392-28-9
  • 5329-28-9
  • C4H8N6H2SO4
  • C4H10N6O4S
  • C4H8N6H2SO4xH2O
  • C4H8N6H2O4S
  • Pyrimidines
  • Heterocyclic Building Blocks