8-OXO-2'-DEOXYGUANOSINE

Product Name: 8-OXO-2'-DEOXYGUANOSINE
CAS No.: 88847-89-6
Chemical Name: 8-OXO-2'-DEOXYGUANOSINE
Synonyms: 8-hydroxydeoxyguanosine;8-Hydroxy-dG;-deoxyguanosine;8-Hydroxy-2'-dG;8-Oxodeoxyguanosine;2-Amino-9-((2R,4S,5R);-3H-purine-6,8(7H,9H);2'-Deoxy-8-oxoguanosine;8-OXO-2'-DEOXYGUANOSINE;8-oxo-2'-deoxyGuanosine
CBNumber: CB6269667
Molecular Formula: C10H13N5O5
Formula Weight: 283.24
MOL File: 88847-89-6.mol

More

Less

8-OXO-2'-DEOXYGUANOSINE Property

Melting point:: 217-220°C
Density: 2.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 10 mg/ml).
form: White to off-white solid.
pka: 7.86±0.20(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

More

Less

Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: MF8782675
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5653
Product name: 8-Hydroxy-2′-deoxyguanosine
Purity: ≥98% (TLC)
Packaging: 1mg
Price: $90.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: H5653
Product name: 8-Hydroxy-2′-deoxyguanosine
Purity: ≥98% (TLC)
Packaging: 5mg
Price: $312
Updated: 2024/03/01

Cayman Chemical

Product number: 89320
Product name: 8-Hydroxy-2'-deoxyguanosine
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 89320
Product name: 8-Hydroxy-2'-deoxyguanosine
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 89320
Product name: 8-Hydroxy-2'-deoxyguanosine
Purity: ≥98%
Packaging: 10mg
Price: $363
Updated: 2024/03/01

More

Less

8-OXO-2'-DEOXYGUANOSINE Chemical Properties,Usage,Production

Description

8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3

Chemical Properties

White Crystalline Solid

Uses

A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.

Uses

8-Hydroxy-2′-deoxyguanosine has been used:

as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
as a standard for LC/MS/MS analysis

Definition

ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

Biochem/physiol Actions

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

References

1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636 2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221 3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41

8-OXO-2'-DEOXYGUANOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

8-OXO-2'-DEOXYGUANOSINE Suppliers

Canada 1 China 89 Germany 3 India 3 Switzerland 3 United Kingdom 4 United States 20 Global 123

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Carbosynth Limited

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6581
Advantage: 61

Glentham Life Sciences

Tel: --
Fax: --
Email: info@glenthamls.com
Country: United Kingdom
ProdList: 1429
Advantage: 0

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

More

Less

View Lastest Price from 8-OXO-2'-DEOXYGUANOSINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 8-OXO-2'-DEOXYGUANOSINE 88847-89-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

88847-89-6, 8-OXO-2'-DEOXYGUANOSINERelated Search:

8-OXO-2'-DEOXYGUANOSINE Loxoribine 8-Benzyloxyguanosine Guanine Purine 7-propyl-8-oxoguanosine 8-HYDROXYGUANOSINE 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-8-OXO-2'-DEOXYGUANOSINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE 8-ALLYLOXY-3'-O-[(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINO]-5'-O-(4,4'-DIMETHOXYTRITYL)-N2-[(DIMETHYLAMINO)METHYLIDINE]-2'-DEOXYGUANOSINE 8-ALLYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 8-ALLYLOXY-2'-DEOXYGUANOSINE Tri-O-acetyl-8-(allyloxy)guanosine 5'-O-(DIMETHOXYTRITYL)-8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE 8-BENZYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE 8-ALLYLOXY-N2-(DMF)-2'-DEOXYGUANOSINE 8-Benzyloxy-2'-deoxy-D-guanosine 8-(Allyloxy)guanosine

8-HYDROXY-2'-DEOXYGUANOSINE

2'-Deoxy-8-oxoguanosine

7,8-Dihydro-8-oxo-2'-deoxyguanosine

8-Oxo-7,8-dihydro-2'-deoxyguanosine

8-Oxo-7,8-dihydrodeoxyguanosine

2'-Deoxy-8-oxo-D-guanosine

8-Oxo-7,8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG

2'-Deoxy-8-hydroxyguanosine

8-Oxodeoxyguanosine

2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione

2-amino-9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3,7-dihydropurine-6,8-quinone

2-azanyl-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione

8-Hydroxy-2′-deoxyguanosine,8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG

8-Hydroxy-2'-deoxyguanosineDiscontinued See O850250

2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione

Guanosine,2'-deoxy-7,8-dihydro-8-oxo-

7,8-dihydro-2’-deoxy-8-oxo-guanosin

2-Amino-9-((2R,4S,5R)

-3H-purine-6,8(7H,9H)

8-Oxo-2'-deoxyguanosine (8-Oxo-dG)

7,8-dihydro-2’-deoxy-8-oxoguanosine

8-hydroxydeoxyguanosine

8-oxo-7-hydrodeoxyguanosine

8-OXO-2'-DEOXYGUANOSINE

8-Hydroxy-desoxyguanosine

Mouse 8-Hydroxy-desoxyguanosine elisa kit

8-OXO-2'-DEOXYGUANOSINE USP/EP/BP

-deoxyguanosine

8-Hydroxy-2'-dG

8-Hydroxy-dG

8-HYDROXY-2'-DEOXYGUANOSINE UNLABELED 25 UG/ML IN WATER

Inhibitor,8Hydroxy2'deoxyguanosine,inhibit,Endogenous Metabolite,8 Hydroxy 2' deoxyguanosine

2-amino-8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

8-oxo-2'-deoxyGuanosine

2'-Deoxy-7,8-dihydro-8-oxoguanosine

2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,7,8,9-tetrahydro-3H-purine-6,8-dione

8-Hydroxy-2'-deoxyguanosine

2’-Deoxy-8-oxoguanosine

8-Hydroxy-2'-deoxyguanosine (8-OHdG）

*Carisoprodol Impurity 4 (Carisoprodol EP Impurity D)(Meprobamate)

Rabbit Anti-8-OHdG (DNA/RNA Damage) antibody

8-Hydroxy-2''-deoxyguanosine, Oxidative stress biomarker

88847-89-6

8847-89-6

Bases & Related Reagents

Labeling and Diagnostics Reagents

Nucleotides

Heterocycles