1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Product Name: 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS No.: 1335210-23-5
Chemical Name: 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
Synonyms: BNKY001-DL01;Dulotegravir Me-N-4;Bictegravir Intermediate;Dolutegravir Impurity 58;Bikagwe-related Compound 1;Intermediate 1 of Drogavel;Dolutegravir Intermediates3;Bictegravir Related Compound 1;Dolutegravir intermediate-1, 10 mM in DMSO;1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxy
CBNumber: CB62714273
Molecular Formula: C13H17NO8
Formula Weight: 315.28
MOL File: 1335210-23-5.mol

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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Property

Boiling point:: 474.1±45.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, DMSO (Slightly), Methanol (Slightly)
pka: 5.56±0.40(Predicted)
form: Solid
color: White to Light Yellow
InChI: InChI=1S/C13H17NO8/c1-19-8(20-2)6-14-5-7(12(16)17)10(15)11(21-3)9(14)13(18)22-4/h5,8H,6H2,1-4H3,(H,16,17)
InChIKey: XAXGEECGULRZGN-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)N(CC(OC)OC)C=C(C(O)=O)C(=O)C=1OC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D528812
Product name: Dolutegravirintermediate-1
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 3307DL
Product name: 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Packaging: 1g
Price: $68
Updated: 2021/12/16

Ambeed

Product number: A277021
Product name: 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Purity: 98%
Packaging: 250mg
Price: $5
Updated: 2021/12/16

Ambeed

Product number: A277021
Product name: 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $6
Updated: 2021/12/16

Ambeed

Product number: A277021
Product name: 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Purity: 98%
Packaging: 5g
Price: $20
Updated: 2021/12/16

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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Chemical Properties,Usage,Production

Uses

Dolutegravir intermediate-1 (1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is used as an intermediate in the synthesis of GSK1265744 (I), a potent HIV integrase inhibitor.

Synthesis

N, N-Dimethylformamide dimethyl acetal was added to methyl 4-methoxy-3-oxobutanoate, and the mixture was kept for 2 h at 25-30°C. The resulting methyl2-(dimethylaminomethylidene)-4-methoxy-3-oxobutanoate was dissolved in methanol, 2-amino acetaldehyde dimethyl acetal was added, and the mixture was stirred at20-30°C for 2 h. The solvent was removed under reduced pressure, the residue was diluted with methanol, and dimethyl oxalate was added at 25-30°C. The mixture was cooled to 0-5°C, 30 wt % sodium methoxide in methanol was slowly added, and the mixture was slowly heated to 40°C, stirred for 14 h at that temperature, and concentrated under reduced pressure. The residue was diluted with dichloromethane and poured into cold (0-5°C)2 N aqueous HCl. The organic phase was separated, the aqueous layer was extracted with dichloromethane (2× ), and the combined organic layers were washed with demineralized water and concentrated under reduced pressure at 40-45 °C to obtain intermediate. The product was dissolved in methanol, the solution was cooled to 0-5°C, and lithium hydroxide monohydrate was added. The mixture was stirred at 0-5°C for 3 h, quenched with 2 N aqueous HCl, and extracted with ethyl acetate (3×). Finally, the product 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid can be obtained through further purification.

IC 50

HIV-1

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Suppliers

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View Lastest Price from 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-19

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-09-26

1335210-23-5, 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acidRelated Search:

(1R,3S)-3-Aminocyclopentanol (1S,3R)-3-Aminocyclopentanol Salmeterol 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Bictegravir GSK1349572 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE O-Methyl Dolutegravir 4-Acetoxy-3-acetoxymethylacetophenone (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine (2R,5S,13aR)-8-methoxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 2,4,6-TRIFLUOROBENZYL AMINE (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid BIS(3,5-DIBROMOSALICYL) FUMARATE

1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester

1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

2,5-Pyridinedicarboxylic acid, 1-(2,2-dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-, 2-methyl ester

Dolutegravir Intermediates3

1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl este

1-(2,2-dimethoxyethyl)-5-methoxy-4-oxo-1,4-dihydropyridine-3,6-dicarboxylic acid-6-methyl ester

Dulotegravir Me-N-4

BNKY001-DL01

Bictegravir Intermediate

(E) -2-(((2,2-dimethoxyethyl) amino) Methylene) -4-methoxy-3-oxobutanoic acid methyl ester

Bictegravir Related Compound 1

(6-(methoxycarbonyl)-1,4-dihydro-5-methoxy-1-(2,2- dimethoxy ethyl)-4-oxopyridine-3-carboxylic acid)

1-(2,2-Dimethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-Dihydropyridine-3-(Methoxycarbonyl)-4-oxo-1,4-Dihydropyridine-3-Carboxylic acid

1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyrid...

Methyl 5-acetyl-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxy

1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid

1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

1-(2,2-diMethoxyethy1)-5-Methoxy-6-(Methoxycarbony1)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

( methoxycarbonyl ) -4 - oxo - 1,4 - dihydropyridine - 3 carboxylic Acid 1- ( 2,2 - Dimethoxyethyl ) -5 - methoxy - 6

Bikagwe-related Compound 1

Dolutegravir Impurity 58

Dolutegravir intermediate-1, 10 mM in DMSO

Intermediate 1 of Drogavel

1335210-23-5

13555210-23-5

CMLLYL