ChemicalBook > CAS DataBase List > 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Product Name
1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS No.
1335210-23-5
Chemical Name
1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
Synonyms
BNKY001-DL01;Dulotegravir Me-N-4;Bictegravir Intermediate;Dolutegravir Impurity 58;Dolutegravir Intermediates3;Bictegravir Related Compound 1;1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxy;1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyrid...;1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid;Methyl 5-acetyl-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate
CBNumber
CB62714273
Molecular Formula
C13H17NO8
Formula Weight
315.28
MOL File
1335210-23-5.mol
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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Property

Boiling point:
474.1±45.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform, DMSO (Slightly), Methanol (Slightly)
pka
5.56±0.40(Predicted)
form 
Solid
color 
White to Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D528812
Product name
Dolutegravirintermediate-1
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
3307DL
Product name
1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Packaging
1g
Price
$68
Updated
2021/12/16
Crysdot
Product number
CD11292488
Product name
1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Purity
97%
Packaging
5g
Price
$149
Updated
2021/12/16
Chemenu
Product number
CM172459
Product name
1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Purity
97%
Packaging
5g
Price
$153
Updated
2021/12/16
Chemenu
Product number
CM172459
Product name
1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid
Purity
97%
Packaging
10g
Price
$224
Updated
2021/12/16
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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Chemical Properties,Usage,Production

Uses

Dolutegravir intermediate-1 (1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is used as an intermediate in the synthesis of GSK1265744 (I), a potent HIV integrase inhibitor.

Synthesis

N, N-Dimethylformamide dimethyl acetal was added to methyl 4-methoxy-3-oxobutanoate, and the mixture was kept for 2 h at 25-30°C. The resulting methyl2-(dimethylaminomethylidene)-4-methoxy-3-oxobutanoate was dissolved in methanol, 2-amino acetaldehyde dimethyl acetal was added, and the mixture was stirred at20-30°C for 2 h. The solvent was removed under reduced pressure, the residue was diluted with methanol, and dimethyl oxalate was added at 25-30°C. The mixture was cooled to 0-5°C, 30 wt % sodium methoxide in methanol was slowly added, and the mixture was slowly heated to 40°C, stirred for 14 h at that temperature, and concentrated under reduced pressure. The residue was diluted with dichloromethane and poured into cold (0-5°C)2 N aqueous HCl. The organic phase was separated, the aqueous layer was extracted with dichloromethane (2× ), and the combined organic layers were washed with demineralized water and concentrated under reduced pressure at 40-45 °C to obtain intermediate. The product was dissolved in methanol, the solution was cooled to 0-5°C, and lithium hydroxide monohydrate was added. The mixture was stirred at 0-5°C for 3 h, quenched with 2 N aqueous HCl, and extracted with ethyl acetate (3×). Finally, the product 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid can be obtained through further purification.

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Suppliers

Shenzhen HwaGen Pharmaceutical Co.,Ltd
Tel
18927339850
Fax
0752-5319394
Email
xiaodong.shi@rafflespt.com
Country
China
ProdList
237
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58
Henan Chongyi Biopharmaceutical Co., Ltd
Tel
182-57818007 13566934155
Fax
QQ1571202295
Email
1571202295@qq.com
Country
China
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11
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58
Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
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China
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568
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Anhui Tokind Advanced Material Co., Ltd.
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0554-2114112 18118134211
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tokind@tokinchem.com
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China
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58
Shanghai SynFarm Pharmaceutical Technology Co., Ltd.
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021-50793966 18917198199
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+86-21-50793967
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info@synfarm.com
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China
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Nanjing Norris-Pharm Technology Co., Ltd
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13901585132
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+86-25-52131256
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799750417@qq.com
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China
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8878
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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
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021-34666753 13311639313
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+86-21-34979012
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info@shyrchem.com
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China
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UHN Shanghai Research & Development Co., Ltd.
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021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
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China
ProdList
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Acesys Pharmatech
Tel
18860950986
Email
tangmanman@zenjipharma.com
Country
China
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1733
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TargetMol Chemicals Inc.
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021-021-33632979 15002134094
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021-33632979
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marketing@targetmol.com
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China
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View Lastest Price from 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester 1335210-23-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2023-09-08
Henan Aochuang Chemical Co.,Ltd.
Product
1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5
Price
US $30.00-28.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2022-09-26

1335210-23-5, 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acidRelated Search:


  • 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester
  • 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid
  • 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
  • 2,5-Pyridinedicarboxylic acid, 1-(2,2-dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-, 2-methyl ester
  • Dolutegravir Intermediates3
  • 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl este
  • 1-(2,2-dimethoxyethyl)-5-methoxy-4-oxo-1,4-dihydropyridine-3,6-dicarboxylic acid-6-methyl ester
  • Dulotegravir Me-N-4
  • BNKY001-DL01
  • Bictegravir Intermediate
  • (E) -2-(((2,2-dimethoxyethyl) amino) Methylene) -4-methoxy-3-oxobutanoic acid methyl ester
  • Bictegravir Related Compound 1
  • (6-(methoxycarbonyl)-1,4-dihydro-5-methoxy-1-(2,2- dimethoxy ethyl)-4-oxopyridine-3-carboxylic acid)
  • 1-(2,2-Dimethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-Dihydropyridine-3-(Methoxycarbonyl)-4-oxo-1,4-Dihydropyridine-3-Carboxylic acid
  • 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyrid...
  • Methyl 5-acetyl-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate
  • 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxy
  • 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid
  • 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
  • 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid
  • 1-(2,2-diMethoxyethy1)-5-Methoxy-6-(Methoxycarbony1)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
  • Dolutegravir Impurity 58
  • ( methoxycarbonyl ) -4 - oxo - 1,4 - dihydropyridine - 3 carboxylic Acid 1- ( 2,2 - Dimethoxyethyl ) -5 - methoxy - 6
  • 1335210-23-5
  • 13555210-23-5
  • CMLLYL