5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
- Product Name
- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
- CAS No.
- 173140-90-4
- Chemical Name
- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
- Synonyms
- (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one;BNKY004-IM01;8-benzoxy-5-(R)-oxiranyl-1H-quinolin-2-one;5-(2R) -2-epoxyl-8-benzoxy-2 (1H) -quinolone;5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone;(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone;2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone;8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one;2(1H)-Quinolinone, 5-(2R)-oxiranyl-8-(phenylmethoxy)-;5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone
- CBNumber
- CB72516579
- Molecular Formula
- C18H15NO3
- Formula Weight
- 293.32
- MOL File
- 173140-90-4.mol
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Property
- Melting point:
- 155 - 157°C
- Boiling point:
- 556.0±50.0 °C(Predicted)
- Density
- 1.298
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.92±0.70(Predicted)
- form
- Solid
- color
- White to Pale Yellow
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B194026
- Product name
- (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B194026
- Product name
- (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
- Packaging
- 100mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CCH0032983
- Product name
- (R)-8-(BENZYLOXY)-5-(OXIRAN-2-YL)QUINOLIN-2(1H)-ONE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $226.8
- Updated
- 2021/12/16
- Product number
- 212988
- Product name
- (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
- Product number
- J11352
- Product name
- IndacaterolImpurity5
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Chemical Properties,Usage,Production
Uses
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
A 5 liter flask equipped with a mechanical stirrer, thermometer, and refluxing condenser was charged with 8-benzyloxy-5-[(R)-(2-bromo-1-hydroxyethyl)]-carbostyriI (70gms/0.187 moles), potassium carbonate (74 gmsl 0.536 moles), acetone (3.5 liters) and water (35 ml). The resulting slurry 'was heated to reflux and maintained for 2% hours. After completion of reaction, the hot mass was filtered on hylo bed to remove inorganics. The residue was slurried in dichloromethane (200 ml) and filtered on hyflo bed. The filtrates were combined together and concentrated under vacuum completely. The residue was dissolved. in dichloromethane (500ml) and filtered on hyflo bed to remove traces of insolubles and washed with dichloromethane(100 ml). The clear filtrate was distilled completely to obtain residue. The residue was charged with methanol (70 ml), stirred and heated to 50??C for 30 minutes. The slurry obtained was cooled to 25-30??C,chilled to 0- 5??C, stirred for 1 hour. The resulting solid was isolated by filtration, washed with methanol (30ml), followed by diisopropylether (100ml) and dried under vacuum at 60-65 ??C for 10-12 hours to yield 40-41 gms of 8-benzyloxy- 5-(R)-oxiranylcarbostyril.
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone manufacturers
- Product
- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 173140-90-4
- Price
- US $65.00-650.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-06
- Product
- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 173140-90-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 173140-90-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KG
- Release date
- 2019-09-04