ChemicalBook > CAS DataBase List > 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

Product Name
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
CAS No.
173140-90-4
Chemical Name
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
Synonyms
(R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one;BNKY004-IM01;8-benzoxy-5-(R)-oxiranyl-1H-quinolin-2-one;5-(2R) -2-epoxyl-8-benzoxy-2 (1H) -quinolone;5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone;(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone;2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone;8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one;2(1H)-Quinolinone, 5-(2R)-oxiranyl-8-(phenylmethoxy)-;5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone
CBNumber
CB72516579
Molecular Formula
C18H15NO3
Formula Weight
293.32
MOL File
173140-90-4.mol
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5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Property

Melting point:
155 - 157°C
Boiling point:
556.0±50.0 °C(Predicted)
Density 
1.298
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
10.92±0.70(Predicted)
form 
Solid
color 
White to Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B194026
Product name
(R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
B194026
Product name
(R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
Packaging
100mg
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032983
Product name
(R)-8-(BENZYLOXY)-5-(OXIRAN-2-YL)QUINOLIN-2(1H)-ONE
Purity
95.00%
Packaging
25MG
Price
$226.8
Updated
2021/12/16
Oakwood
Product number
212988
Product name
(R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
Purity
95+%
Packaging
1g
Price
$420
Updated
2021/12/16
AK Scientific
Product number
J11352
Product name
IndacaterolImpurity5
Packaging
25mg
Price
$45
Updated
2021/12/16
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5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Chemical Properties,Usage,Production

Uses

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


A 5 liter flask equipped with a mechanical stirrer, thermometer, and refluxing condenser was charged with 8-benzyloxy-5-[(R)-(2-bromo-1-hydroxyethyl)]-carbostyriI (70gms/0.187 moles), potassium carbonate (74 gmsl 0.536 moles), acetone (3.5 liters) and water (35 ml). The resulting slurry 'was heated to reflux and maintained for 2% hours. After completion of reaction, the hot mass was filtered on hylo bed to remove inorganics. The residue was slurried in dichloromethane (200 ml) and filtered on hyflo bed. The filtrates were combined together and concentrated under vacuum completely. The residue was dissolved. in dichloromethane (500ml) and filtered on hyflo bed to remove traces of insolubles and washed with dichloromethane(100 ml). The clear filtrate was distilled completely to obtain residue. The residue was charged with methanol (70 ml), stirred and heated to 50??C for 30 minutes. The slurry obtained was cooled to 25-30??C,chilled to 0- 5??C, stirred for 1 hour. The resulting solid was isolated by filtration, washed with methanol (30ml), followed by diisopropylether (100ml) and dried under vacuum at 60-65 ??C for 10-12 hours to yield 40-41 gms of 8-benzyloxy- 5-(R)-oxiranylcarbostyril.

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Suppliers

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View Lastest Price from 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 173140-90-4
Price
US $65.00-650.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-06
Henan Aochuang Chemical Co.,Ltd.
Product
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 173140-90-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Career Henan Chemical Co
Product
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 173140-90-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2019-09-04

173140-90-4, 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinoneRelated Search:

Indacaterol interMediate Indacaterol 2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide Triphenylmethanol (S)-Indacaterol Indacaterol Impurity 3 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide Fimasartan Indacaterol Maleate 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Indacaterol Impurity 12 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide METHYL TRIPHENYLMETHYL ETHER

  • (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one
  • 2(1H)-Quinolinone, 5-(2R)-oxiranyl-8-(phenylmethoxy)-
  • 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
  • Indacaterol interMediate :2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
  • 8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one
  • 2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
  • 8-benzoxy-5-(R)-oxiranyl-1H-quinolin-2-one
  • (R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone
  • BNKY004-IM01
  • 5-[(2R)-oxiran-2-yl]-8-phenylmethoxy-1H-quinolin-2-one
  • 2(1H)-Quinolinone, 5-(2R)-2-oxiranyl-8-(phenylmethoxy)-
  • 8-(benzyloxy)-5-((1R)-2-((5-ethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-2(1H)-one fumarate
  • (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one( Indacaterol Impurity 5)
  • 5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone
  • 5- (2R) -2-epoxyethanyl-8-benzyloxy-2 (1H) - quinolone
  • 5-(2R) -2-epoxyl-8-benzoxy-2 (1H) -quinolone
  • 173140-90-4