O-Methyl Dolutegravir

Product Name: O-Methyl Dolutegravir
CAS No.: 1335210-35-9
Chemical Name: O-Methyl Dolutegravir
Synonyms: BNKY001-DL03;O-Methyl Dolutegravir;Dolutegravir O-Methyl Imp;Doultegravir O methyl impurity;Dolutegravir O-Methyl Impurity;(4r,12as)-n-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexa...;(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-methoxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide;(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide;(4R,12AS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-car boxamide
CBNumber: CB42729257
Molecular Formula: C21H21F2N3O5
Formula Weight: 433.41
MOL File: 1335210-35-9.mol

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O-Methyl Dolutegravir Property

Boiling point:: 684.3±55.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.70±0.40(Predicted)

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Safety

HS Code: 38220090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D448554
Product name: O-MethylDolutegravir
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Crysdot

Product number: CD11292484
Product name: (4R,12AS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Purity: 97%
Packaging: 1g
Price: $475
Updated: 2021/12/16

Alichem

Product number: 1335210359
Product name: (4R,12AS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Packaging: 1g
Price: $480
Updated: 2021/12/16

Crysdot

Product number: CD11292484
Product name: (4R,12AS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Purity: 97%
Packaging: 5g
Price: $1426
Updated: 2021/12/16

Alichem

Product number: 1335210359
Product name: (4R,12AS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Packaging: 5g
Price: $1526.4
Updated: 2021/12/16

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O-Methyl Dolutegravir Chemical Properties,Usage,Production

Description

Dolutegravir intermediate is a new synthetic intermediate of Dolutegravir. Dolutegravir is an integrase inhibitor used to treat human immunodeficiency virus (HIV)-1 infection.

Uses

(4R,12AS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide is an intermediate in the preparation of dolutegravir, an integrase inhibitor for HIV-1 infection therapy.

Synthesis

(3S,11aR)-3-methyl-6-(methyloxy)-5,7-dioxo-2,3,5,7,11,11a- hexahydro[1,3]oxazolo [3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid (100 gm) and carbonyl dimidazole (78.89 gm) was suspended in acetonitrile (1000 mL). The mixture was heated to 75°C and stirred for 1 hour. The resulting solution was cooled to a temperature of 20°C and treated with 2,4- difluorobenzyl amine solution (55.2 gm was dissolved in 200 mL of acetonitrile). The reaction mixture was maintained for 2 hours, concentrated, and the compound was extracted with ethyl acetate (1000 mL). Isopropyl alcohol (500 mL) was added at 40°C, stirred the reaction mass for 30 minutes at a temperature of 50°C, and cooled the reaction mass to 25°C. The reaction mixture was maintained for 8 hours at the same temperature. The product O-Methyl Dolutegravir was collected by filtration and dried under vacuum (85 gm).

O-Methyl Dolutegravir Preparation Products And Raw materials

Raw materials

Preparation Products

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O-Methyl Dolutegravir Suppliers

China 59 India 6 United Kingdom 1 United States 4 Global 70

Shenzhen Roark Pharma-Tec Co., Ltd.

Tel: 13128912434
Email: 2880126944@qq.com
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Shanghai SynFarm Pharmaceutical Technology Co., Ltd.

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Fax: +86-21-50793967
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Nanjing Norris-Pharm Technology Co., Ltd

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Shenzhen HwaGen Pharmaceutical Co.,Ltd

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ChemStrong Scientific Co.,Ltd

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Zhengzhou Acme Chemical Co., Ltd.

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Amadis Chemical Company Limited

Tel: 571-89925085
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Country: China
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Lynnchem

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Suzhou Laihui Biotechnology Co., Ltd.

Tel: 180-13160973 18013160973
Fax: 0512-68236973
Email: rywaybio@gmail.com
Country: China
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View Lastest Price from O-Methyl Dolutegravir manufacturers

Career Henan Chemica Co

Product: (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide 1335210-35-9
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-10-28

Shanghai Yingrui Biopharma Co., Ltd.

Product: (4R,12aS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide 1335210-35-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100t
Release date: 2018-03-06

1335210-35-9, O-Methyl DolutegravirRelated Search:

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Dolutegravir 4-Desfluoro Impurity IMpurity of Dolutegravir Dolutegravir 2-Desfluoro Impurity GSK1349572 Dolutegravir Impurity 3 Dolutegravir sodium Dolutegravir Impurity 6 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Bictegravir (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE 4-Acetoxy-3-acetoxymethylacetophenone (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide

Dolutegravir O-Methyl Imp

Dolutegravir impurity 5/O-Methyl Dolutegravir/(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-, (4R,12aS)-

O-Methyl Dolutegravir

BNKY001-DL03

(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-car boxamide

Dolutegravir O-Methyl Impurity

Doultegravir O methyl impurity

(4r,12as)-n-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexa...

(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-methoxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide

(4R,12AS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

1335210-35-9

C21H21F2N3O5

CMLLYL