Dolutegravir 4-Desfluoro Impurity

Product Name: Dolutegravir 4-Desfluoro Impurity
CAS No.: 1863916-87-3
Chemical Name: Dolutegravir 4-Desfluoro Impurity
Synonyms: Dotiravir Impurity 2;Dotiravir Impurity 8;2-Fluoro Dolutegravir;4-Defluoro Dolutegravir;Dolutegravir Impurity 49;Dolutegravir Impurity 46;Doultegravir 2-F Impurity C;Dolutegravir 2-Fluoro Impurity;Dolutegravir Impurity C (4-Defluoro Dolutegravir);(4R,12aS)-N-(2-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
CBNumber: CB94796146
Molecular Formula: C20H20FN3O5
Formula Weight: 401.39
MOL File: 1863916-87-3.mol

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Dolutegravir 4-Desfluoro Impurity Property

Boiling point:: 671.6±55.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
pka: 4.50±1.00(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D228820
Product name: 4-DefluoroDolutegravir
Packaging: 2.5mg
Price: $445
Updated: 2021/12/16

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Dolutegravir 4-Desfluoro Impurity Chemical Properties,Usage,Production

Uses

4-Defluro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir 4-Desfluoro Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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Dolutegravir 4-Desfluoro Impurity Suppliers

China 27 India 7 United States 1 Global 35

Beijing Comparison Pharmaceutical Technology Co., Ltd

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1863916-87-3, Dolutegravir 4-Desfluoro ImpurityRelated Search:

IMpurity of Dolutegravir Dolutegravir 2-Desfluoro Impurity GSK1349572 Dolutegravir Impurity 3 Dolutegravir sodium Dolutegravir Impurity 6 O-Methyl Dolutegravir

Dolutegravir impurity 1/4-Defluoro Dolutegravir/(4R,12aS)-N-(2-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

(4R,12aS)-N-(2-fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

4-Defluoro Dolutegravir

2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2-fluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-

Dolutegravir Impurity C (4-Defluoro Dolutegravir)

Doultegravir 2-F Impurity C

Dolutegravir Impurity 46

Dolutegravir Impurity 49

2-Fluoro Dolutegravir

Dolutegravir 2-Fluoro Impurity

Dotiravir Impurity 2

Dotiravir Impurity 8

1863916-87-3