Fmoc-3VVD-OH
- Product Name
- Fmoc-3VVD-OH
- CAS No.
- 863971-44-2
- Chemical Name
- Fmoc-3VVD-OH
- Synonyms
- (5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid;FMOC-3AA-OH;Fmoc-3AA-orl;Fmoc-3vvd-OH;4-[(2-{2-[(9H;Tripeptide (MMAE-3);Fmoc-MeVal-Val-Dil-OH;FMOC-3VVD-OH, 10 mM in DMSO;Fmoc-Meval-val-dolaisoleucine-OH;Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH）
- CBNumber
- CB62715760
- Molecular Formula
- C36H51N3O7
- Formula Weight
- 637.81
- MOL File
- 863971-44-2.mol
Fmoc-3VVD-OH Property
- Boiling point:
- 793.0±60.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- solubility
- DMSO: ≥ 37 mg/mL (58.01 mM)
- pka
- 4.08±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water: < 0.1 mg/mL (insoluble)
- InChIKey
- JDMOCVJBADMSJP-FCUBIXSHSA-N
- SMILES
- C(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-M2761
- Product name
- Fmoc-3VVD-OH
- Purity
- ≥99.0%
- Packaging
- 500mg
- Price
- $2500
- Updated
- 2021/12/16
Fmoc-3VVD-OH Chemical Properties,Usage,Production
Description
Fmoc-3vvd-OH, chemically known as (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid, is an antibody-drug conjugate (ADC) linker. Fmoc-3vvd-OH is also an intermediate in the synthesis of MMAE. The Fmoc protecting group can be removed with a base (usually piperidine) to reveal the methylated N-terminus of the peptide.
Uses
Fmoc-3VVD-OH is a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis.
Biological Activity
Fmoc-3VVD-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
in vivo
ADCs consist of antibodies linked to ADC cytotoxins through ADC linkers.
target
| Cleavable
|
Fmoc-3VVD-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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