ChemicalBook > CAS DataBase List > GDC-0994

GDC-0994

Product Name
GDC-0994
CAS No.
1453848-26-4
Chemical Name
GDC-0994
Synonyms
CS-1841;GDC-0994;RG-7842);EOS-60648;Ravoxertinib;GDC-0994;RAVOXERTINIB;RAVOXERTINIB (GDC-0994);GDC 0994;GDC-0994;GDC0994;GDC-0994 (RAVOXERTINIB, RG7842);1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
CBNumber
CB62716237
Molecular Formula
C21H18ClFN6O2
Formula Weight
440.86
MOL File
1453848-26-4.mol
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GDC-0994 Property

Boiling point:
734.6±70.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH
form 
solid
pka
14.03±0.10(Predicted)
color 
White to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
10mg
Price
$426
Updated
2024/03/01
TRC
Product number
G299910
Product name
GDC-0994
Packaging
2.5mg
Price
$1105
Updated
2021/12/16
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GDC-0994 Chemical Properties,Usage,Production

Description

GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively. It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.

Uses

GDC-0994 is a potent and orally available ERK12 inhibitor shown to prevent ERK-dependant tumor cell proliferation and survival.

References

[1]. robarge k, schwarz j, blake j, et al. abstract ddt02-03: discovery of gdc-0994, a potent and selective erk1/2 inhibitor in early clinical development. aacr annual meeting, 2014, san diego, ca.

GDC-0994 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0994 Suppliers

China 94 India 1 United States 15 Global 110
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
ApexBio Technology
Tel
--
Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
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View Lastest Price from GDC-0994 manufacturers

Career Henan Chemical Co
Product
GDC-0994 1453848-26-4
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

1453848-26-4, GDC-0994Related Search:


  • GDC-0994
  • (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one GDC-0994
  • (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
  • 1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone
  • Ravoxertinib
  • EOS-60648
  • GDC 0994;GDC-0994;GDC0994
  • CS-1841
  • GDC-0994;RAVOXERTINIB
  • RAVOXERTINIB (GDC-0994)
  • 2(1H)-Pyridinone, 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-
  • RG-7842)
  • 1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
  • GDC-0994 (RAVOXERTINIB, RG7842)
  • 1453848-26-4
  • C21H18ClFN6O2
  • Inhibitors