URMC-099

ChemicalBook > CAS DataBase List > URMC-099

Product Name: URMC-099
CAS No.: 1229582-33-5
Chemical Name: URMC-099
Synonyms: RMC099;CS-1776;URMC-099;URMC-099;URMC 099;inhibit,MLKs,Autophagy,URMC 099,URMC099,URMC-099,Inhibitor,Mixed Lineage Kinase;3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine;1H-?Pyrrolo[2,?3-?b]?pyridine, 3-?(1H-?indol-?5-?yl)?-?5-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?phenyl]?-;3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine URMC-099
CBNumber: CB62719728
Molecular Formula: C27H27N5
Formula Weight: 421.54
MOL File: 1229582-33-5.mol

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URMC-099 Property

Density: 1.256±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 13.49±0.40(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19147
Product name: URMC-099
Purity: ≥95%
Packaging: 5mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 19147
Product name: URMC-099
Purity: ≥95%
Packaging: 1mg
Price: $29
Updated: 2022/04/27

Cayman Chemical

Product number: 19147
Product name: URMC-099
Purity: ≥95%
Packaging: 10mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 19147
Product name: URMC-099
Purity: ≥95%
Packaging: 25mg
Price: $162
Updated: 2024/03/01

TRC

Product number: U842000
Product name: URMC-099
Packaging: 1mg
Price: $105
Updated: 2021/12/16

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URMC-099 Chemical Properties,Usage,Production

Description

URMC-099 (1229582-33-5) is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid-β degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5

Uses

URMC-099 is an orally bioavailable MLK3 inhibitor used in the treatment of Parkinson’s disease and HIV-1 associated neurocognitive disorders.

References

1) Goodfellow et al. (2013), Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3; J. Med. Chem. 56 8032 2) Marker et al. (2013), The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders; J. Neurosc. 33 9998 3) Dong et al. (2016), The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation; J. Neuroinflammation 13 184 4) Kiyota et al. (2018), URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease; J. Neuroinflammation 15 137 5) Kumar et al. (2020), Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity; Proc. Natl. Acad. Sci. USA 9 34567

URMC-099 Preparation Products And Raw materials

Raw materials

Preparation Products

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URMC-099 Suppliers

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3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine URMC-099

URMC-099

3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine

1H-?Pyrrolo[2,?3-?b]?pyridine, 3-?(1H-?indol-?5-?yl)?-?5-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?phenyl]?-

CS-1776

URMC-099;URMC 099

RMC099

inhibit,MLKs,Autophagy,URMC 099,URMC099,URMC-099,Inhibitor,Mixed Lineage Kinase

1229582-33-5

C27H27N5

Inhibitors

api