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Z-THR(TBU)-OH

Product Name
Z-THR(TBU)-OH
CAS No.
16966-09-9
Chemical Name
Z-THR(TBU)-OH
Synonyms
Z-THR(TBU)-OH;Cbz-Thr(tBu)-OH;Cbz-L-Thr(tBu)-OH;Linaclotide Impurity 24;O-(tert-Butyl)-N-Cbz-L-threonine;N-((Benzyloxy)Carbonyl)-O-(Tert-Butyl)-L-Threonine, ≥98%;L-Threonine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-;(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid;(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoicacid
CBNumber
CB62729569
Molecular Formula
C16H23NO5
Formula Weight
309.36
MOL File
16966-09-9.mol
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Z-THR(TBU)-OH Property

Boiling point:
470.1±45.0 °C(Predicted)
Density 
1.152±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
pka
3.51±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB166469
Product name
(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
Packaging
25g
Price
$65
Updated
2021/12/16
Activate Scientific
Product number
AS48433-A
Product name
Cbz-O-tert-butyl-L-threonine
Purity
97% ee
Packaging
5G
Price
$67
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB166469
Product name
(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
Packaging
50g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
5843CQ
Product name
(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoicacid
Packaging
50g
Price
$185
Updated
2021/12/16
Activate Scientific
Product number
AS48433-A
Product name
Cbz-O-tert-butyl-L-threonine
Purity
97% ee
Packaging
25g
Price
$224
Updated
2021/12/16
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Z-THR(TBU)-OH Chemical Properties,Usage,Production

Uses

N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-threonine is a threonine derivative[1].

Synthesis

52785-41-8

16966-09-9

The general procedure for the synthesis of (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid from linaclotide impurity 23 was as follows: z-Thr(tBu)-OMe (169 g) was added to a 2 L beaker with 300 mL of acetone and 600 mL of 1,2-dichloroethane, and the pH was adjusted to 10-11 with 1 M sodium hydroxide solution. After completion of the reaction, the reaction was washed once with 500 mL of ether, 800 mL of ethyl acetate was added, and the pH was adjusted to 2-3 with aqueous citric acid solution.Subsequently, the reaction was washed with 300 mL of water, and then with 300 mL of saturated brine. The organic phase was dried over 100 g of anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the residue was added 500 mL of ether and dried to obtain Z-Thr(tBu)-OH (130 g) in granular form in 80.3% yield.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

Z-THR(TBU)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-THR(TBU)-OH Suppliers

China 54 India 1 United Kingdom 1 United States 3 Global 59
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
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View Lastest Price from Z-THR(TBU)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Cbz-L-Thr(tBu)-OH 16966-09-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-15
Career Henan Chemical Co
Product
Z-THR(TBU)-OH 16966-09-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15
Career Henan Chemical Co
Product
Z-THR(TBU)-OH 16966-09-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-15

16966-09-9, Z-THR(TBU)-OHRelated Search:

Z-Thr(TBDMS)-OH Z-THR(TBU)-OH DCHA

  • Z-THR(TBU)-OH
  • N-((Benzyloxy)Carbonyl)-O-(Tert-Butyl)-L-Threonine, ≥98%
  • L-Threonine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-
  • Cbz-Thr(tBu)-OH
  • (2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
  • (2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoicacid
  • O-(tert-Butyl)-N-Cbz-L-threonine
  • Cbz-L-Thr(tBu)-OH
  • Linaclotide Impurity 24
  • 16966-09-9