ChemicalBook > CAS DataBase List > Tipiracil

Tipiracil

Product Name: Tipiracil
CAS No.: 183204-74-2
Chemical Name: Tipiracil
Synonyms: Tipiracil;MA 1 (pharmaceutical);TPI (thymidine phosphorylase inhibitor);2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidi...;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione;5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,;2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-;Tipiracil D4Q: What is Tipiracil D4 Q: What is the CAS Number of Tipiracil D4
CBNumber: CB62744247
Molecular Formula: C9H11ClN4O2
Formula Weight: 242.66
MOL File: 183204-74-2.mol

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Tipiracil Property

Density: 1.71±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Water: 1 mg/mL (4.12 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
pka: 7.06±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5895
Product name: Tipiracil
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-5895
Product name: Tipiracil
Packaging: 10mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-5895
Product name: Tipiracil
Packaging: 50mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5895
Product name: Tipiracil
Packaging: 100mg
Price: $240
Updated: 2021/12/16

Crysdot

Product number: CD11179349
Product name: Tipiracil
Purity: 95+%
Packaging: 10mg
Price: $52
Updated: 2021/12/16

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Tipiracil Chemical Properties,Usage,Production

Uses

Tipiracil-13C, 15N2 is carbon-13 and nitrogen-15 labeled Tipiracil,an inhibitor of human thymidine phosphorylase (TP).Thymidine phosphorylase is an enzyme that converts thymidine to thymine and is a platelet-derived endothelial cell growth factor.

Definition

ChEBI: Tipiracil is a member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer. It has a role as an antineoplastic agent and an EC 2.4.2.4 (thymidine phosphorylase) inhibitor. It is a pyrimidone, an organochlorine compound, a carboxamidine and a member of pyrrolidines. It is functionally related to a uracil. It is a conjugate base of a tipiracil(1+).

Mode of action

Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism. TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, or with an anti-VEGF or anti-EGFR therapy.

Tipiracil Preparation Products And Raw materials

Raw materials

Preparation Products

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Tipiracil Suppliers

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View Lastest Price from Tipiracil manufacturers

Career Henan Chemica Co

Product: 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione, 183204-74-2
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2020-11-12

183204-74-2, TipiracilRelated Search:

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5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,

5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione

MA 1 (pharmaceutical)

TPI (thymidine phosphorylase inhibitor)

2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-

2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidi...

Tipiracil D4Q: What is Tipiracil D4 Q: What is the CAS Number of Tipiracil D4

Tipiracil

183204-74-2