3-METHOXYBENZENESULFONYL CHLORIDE
- Product Name
- 3-METHOXYBENZENESULFONYL CHLORIDE
- CAS No.
- 10130-74-2
- Chemical Name
- 3-METHOXYBENZENESULFONYL CHLORIDE
- Synonyms
- AKOS BB-9459;3-Methoxybenzene;3-METHOXYBENZENESULF;m-Anisolesulfonylchloride;3-(Chlorosulphonyl)anisole;m-Anisolesulphonyl chloride;3-Methoxybenzensulfonyl chloride;3-METHOXYBENZENESULFONYL CHLORIDE;m-Methoxybenzenesulfonyl Chloride;3-METHOXYBENZENESULPHONYL CHLORIDE
- CBNumber
- CB6275581
- Molecular Formula
- C7H7ClO3S
- Formula Weight
- 206.65
- MOL File
- 10130-74-2.mol
3-METHOXYBENZENESULFONYL CHLORIDE Property
- Boiling point:
- 158-159°C 20mm
- Density
- 1.460 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5560(lit.)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- color
- Clear pale yellow to pale brownish
- Sensitive
- Moisture Sensitive
- BRN
- 2093871
- CAS DataBase Reference
- 10130-74-2(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-39-37-36
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive/Moisture Sensitive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 556165
- Product name
- 3-Methoxybenzenesulfonyl chloride
- Purity
- 96%
- Packaging
- 5g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- 556165
- Product name
- 3-Methoxybenzenesulfonyl chloride
- Purity
- 96%
- Packaging
- 1g
- Price
- $84.2
- Updated
- 2025/07/31
- Product number
- M220840
- Product name
- 3-Methoxybenzenesulfonyl chloride
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 018134
- Product name
- 3-Methoxybenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 018134
- Product name
- 3-Methoxybenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $92
- Updated
- 2021/12/16
3-METHOXYBENZENESULFONYL CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Clear pale yellow to pale brownish liquid
Uses
3-Methoxybenzenesulfonyl chloride may be used to synthesize 3-(4-phenylpiperazin-1yl) sulfonyls and N-(1-(4-methoxybenzyl)-3-cyclopropyl-1Hpyrazol-5-yl)-3-methoxybenzenesulfonamide.
Synthesis
19183-05-2
10130-74-2
In another flask, a mixed solution of 450 mL of glacial acetic acid with 45 mL of water was saturated with sulfur dioxide gas at 25°C (about 180 g of sulfur dioxide was required). To this saturated solution, 20.4 g (0.12 mol) of copper(II) chloride was added and sulfur dioxide gas was passed again to saturation. A pre-prepared and cooled diazonium salt solution was added slowly and dropwise to the above stirred mixture in the range of 20-26 °C. There was a release of gas during the reaction, followed by a slow increase of the reaction temperature to 38°C. When the temperature started to drop naturally, external heating was applied to keep the mixture stirred at 50°C for 15 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by pouring into 2 kg of ice water. The oily product in the reaction mixture was extracted with ether (2 x 1000 mL). The ether layers were combined and washed sequentially with 1N NaOH solution (2×1000 mL), 1N HCl solution (2×1000 mL), and saturated brine (1×1000 mL), then dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 59.59 g of dark-colored oily crude product. The crude product was purified by silica gel column chromatography (silica gel dosage: 900 g) with dichloromethane/hexane (1:4, v/v) as eluent to give 43.52 g (43% yield) of 3-methoxybenzenesulfonyl chloride and 3.18 g of unidentified impurities. The products were analyzed by thin-layer chromatography (TLC) using silica gel plates with dichloromethane:hexane (1:1) as the unfolding agent, with an Rf value of 0.56 for the products and 0.41 for the impurities.
References
[1] Patent: US6342504, 2002, B1. Location in patent: Page column 124
3-METHOXYBENZENESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-METHOXYBENZENESULFONYL CHLORIDE manufacturers
- Product
- 3-METHOXYBENZENESULFONYL CHLORIDE 10130-74-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 200kgs
- Release date
- 2020-01-16