ChemicalBook > CAS DataBase List > 3-METHOXYBENZENESULFONYL CHLORIDE

3-METHOXYBENZENESULFONYL CHLORIDE

Product Name: 3-METHOXYBENZENESULFONYL CHLORIDE
CAS No.: 10130-74-2
Chemical Name: 3-METHOXYBENZENESULFONYL CHLORIDE
Synonyms: AKOS BB-9459;3-Methoxybenzene;3-METHOXYBENZENESULF;m-Anisolesulfonylchloride;3-(Chlorosulphonyl)anisole;m-Anisolesulphonyl chloride;3-Methoxybenzensulfonyl chloride;3-METHOXYBENZENESULFONYL CHLORIDE;m-Methoxybenzenesulfonyl Chloride;3-METHOXYBENZENESULPHONYL CHLORIDE
CBNumber: CB6275581
Molecular Formula: C7H7ClO3S
Formula Weight: 206.65
MOL File: 10130-74-2.mol

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3-METHOXYBENZENESULFONYL CHLORIDE Property

Boiling point:: 158-159°C 20mm
Density: 1.460 g/mL at 25 °C (lit.)
refractive index: n20/D 1.5560(lit.)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Liquid
color: Clear pale yellow to pale brownish
Sensitive: Moisture Sensitive
BRN: 2093871
CAS DataBase Reference: 10130-74-2(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34
Safety Statements: 26-36/37/39-45-39-37-36
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive/Moisture Sensitive
HazardClass: 8
PackingGroup: II
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 556165
Product name: 3-Methoxybenzenesulfonyl chloride
Purity: 96%
Packaging: 5g
Price: $83
Updated: 2025/07/31

Sigma-Aldrich

Product number: 556165
Product name: 3-Methoxybenzenesulfonyl chloride
Purity: 96%
Packaging: 1g
Price: $84.2
Updated: 2025/07/31

TRC

Product number: M220840
Product name: 3-Methoxybenzenesulfonyl chloride
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 018134
Product name: 3-Methoxybenzenesulfonyl chloride
Purity: 97%
Packaging: 5g
Price: $32
Updated: 2021/12/16

Matrix Scientific

Product number: 018134
Product name: 3-Methoxybenzenesulfonyl chloride
Purity: 97%
Packaging: 25g
Price: $92
Updated: 2021/12/16

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3-METHOXYBENZENESULFONYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow to pale brownish liquid

Uses

3-Methoxybenzenesulfonyl chloride may be used to synthesize 3-(4-phenylpiperazin-1yl) sulfonyls and N-(1-(4-methoxybenzyl)-3-cyclopropyl-1Hpyrazol-5-yl)-3-methoxybenzenesulfonamide.

Synthesis

19183-05-2

10130-74-2

In another flask, a mixed solution of 450 mL of glacial acetic acid with 45 mL of water was saturated with sulfur dioxide gas at 25°C (about 180 g of sulfur dioxide was required). To this saturated solution, 20.4 g (0.12 mol) of copper(II) chloride was added and sulfur dioxide gas was passed again to saturation. A pre-prepared and cooled diazonium salt solution was added slowly and dropwise to the above stirred mixture in the range of 20-26 °C. There was a release of gas during the reaction, followed by a slow increase of the reaction temperature to 38°C. When the temperature started to drop naturally, external heating was applied to keep the mixture stirred at 50°C for 15 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by pouring into 2 kg of ice water. The oily product in the reaction mixture was extracted with ether (2 x 1000 mL). The ether layers were combined and washed sequentially with 1N NaOH solution (2×1000 mL), 1N HCl solution (2×1000 mL), and saturated brine (1×1000 mL), then dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 59.59 g of dark-colored oily crude product. The crude product was purified by silica gel column chromatography (silica gel dosage: 900 g) with dichloromethane/hexane (1:4, v/v) as eluent to give 43.52 g (43% yield) of 3-methoxybenzenesulfonyl chloride and 3.18 g of unidentified impurities. The products were analyzed by thin-layer chromatography (TLC) using silica gel plates with dichloromethane:hexane (1:1) as the unfolding agent, with an Rf value of 0.56 for the products and 0.41 for the impurities.

References

[1] Patent: US6342504, 2002, B1. Location in patent: Page column 124

3-METHOXYBENZENESULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials

Copper(II) chloride Sodium sulfite m-Anisidine Toluene Sodium nitrite Copper(I) chloride Hydrochloric acid Sodium bicarbonate Acetic acid Sulfuric acid

Preparation Products

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3-METHOXYBENZENESULFONYL CHLORIDE Suppliers

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View Lastest Price from 3-METHOXYBENZENESULFONYL CHLORIDE manufacturers

Career Henan Chemical Co

Product: 3-METHOXYBENZENESULFONYL CHLORIDE 10130-74-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 200kgs
Release date: 2020-01-16

10130-74-2, 3-METHOXYBENZENESULFONYL CHLORIDERelated Search:

BENZENESULFONYL CHLORIDE, 3-METHOXY-

AKOS BB-9459

3-METHOXYBENZENESULPHONYL CHLORIDE

3-METHOXYBENZENESULFONYL CHLORIDE

m-Anisolesulphonyl chloride

m-Anisolesulfonylchloride

3-Methoxybenzenesulphonyl chloride 97%

3-methoxybenzene-1-sulfonyl chloride

3-METHOXYBENZENESULF

3-Methoxybenzenesulfonyl chloride,96%

3-(Chlorosulphonyl)anisole

3-Methoxybenzenesulfonyl chloride 96%

3-Methoxybenzene

3-Methoxybenzensulfonyl chloride

m-Methoxybenzenesulfonyl Chloride

10130-74-2

C7H7O3ClS

SULFONYL CHLORIDE

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds

Building Blocks

Sulfonyl Halides

Sulfur Compounds

Benzenesulfonyl chloride

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds

Building Blocks

Chemical Synthesis

Organic Building Blocks