2-(3-Amino-4-chloro-benzoyl)benzoic acid
- Product Name
- 2-(3-Amino-4-chloro-benzoyl)benzoic acid
- CAS No.
- 118-04-7
- Chemical Name
- 2-(3-Amino-4-chloro-benzoyl)benzoic acid
- Synonyms
- NH2-CBB;LABOTEST-BB LT00012586;Chlortalidone Impurity 4;Chlortalidone Impurity 14;2-(3-Amino-4-chlorobenzoyl)ben;3-Amino-2-Carboxy-4-Chlorobenzophenone;2-(3-amino-4-chlorobenzoyl)-benzoicaci;2-(3-AMINO-4-CHLOROBENZOYL)BENZOIC ACID;2-(4-CHLORO-3-AMINOBENZOYL) BENZOIC ACID;BENZOIC ACID, 2-(3-AMINO-4-CHLOROBENZOYL)
- CBNumber
- CB6281465
- Molecular Formula
- C14H10ClNO3
- Formula Weight
- 275.69
- MOL File
- 118-04-7.mol
2-(3-Amino-4-chloro-benzoyl)benzoic acid Property
- Melting point:
- 181.5-182.0 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 538.6±50.0 °C(Predicted)
- Density
- 1.418±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.24±0.36(Predicted)
- color
- Pale Yellow
- CAS DataBase Reference
- 118-04-7(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 2-(3-amino-4-chlorobenzoyl)- (118-04-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PH011586
- Product name
- 2-(3-amino-4-chlorobenzoyl)benzoic acid
- Purity
- AldrichCPR
- Packaging
- 500mg
- Price
- $134
- Updated
- 2023/06/20
- Product number
- A603200
- Product name
- 2-(3-amino-4-chlorobenzoyl)benzoic acid
- Packaging
- 2.5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FA38888
- Product name
- 2-(3'-Amino-4'-chlorobenzoyl)benzoic acid
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- G526
- Product name
- 2-(3-amino-4-chlorobenzoyl)benzoic acid
- Packaging
- 5g
- Price
- $158.76
- Updated
- 2021/12/16
- Product number
- FA38888
- Product name
- 2-(3'-Amino-4'-chlorobenzoyl)benzoic acid
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
2-(3-Amino-4-chloro-benzoyl)benzoic acid Chemical Properties,Usage,Production
Uses
2-(3-Amino-4-chlorobenzoyl)benzoic Acid is a useful synthetic intermediate. It is used to prepare protein kinase C phosphorylates synthetic fluorescent reporter.
Synthesis
85-54-1
118-04-7
A. To a reaction vessel was added 0.23 mol of 2-(4-chloro-3-nitrobenzoyl)benzoic acid, 300 mL of a 35% by mass sodium nitrate solution and 500 mL of a 24% by mass potassium carbonate solution. The temperature of the solution was raised to 60 °C, followed by the addition of 1.31 g of chlorobenzoic acid solution, 0.311 g of cuprous chloride and 0.211 g of potassium iodide. The stirring speed was controlled to 160 rpm and the temperature of the solution was raised to 70 °C and refluxed for 3 hours. B. The reaction solution was cooled to 20 °C and filtered. The filter cake was washed with sodium bisulfite solution with a mass fraction of 52%, then the temperature of the washed solution was raised to 50 °C, 300 mL of ammonium chloride solution with a mass fraction of 37% was added, and stirred for 90 minutes. C. The solution was cooled to 10 °C and filtered by pumping. The filter cake was washed with potassium bromide solution and subsequently dehydrated with anhydrous magnesium sulfate as dehydrating agent to finally obtain 2-(3-amino-4-chlorobenzoyl)benzoic acid (60.30 g, 95% yield).
References
[1] Russian Journal of Organic Chemistry, 2001, vol. 37, # 5, p. 673 - 676
[2] Patent: CN105906521, 2016, A. Location in patent: Paragraph 0019; 0020; 0021; 0022; 0023
[3] Angewandte Chemie - International Edition, 1999, vol. 38, # 18, p. 2777 - 2779
[4] Patent: DE148110,
[5] Journal of Medicinal Chemistry, 1965, vol. 8, p. 691 - 694
2-(3-Amino-4-chloro-benzoyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3-Amino-4-chloro-benzoyl)benzoic acid Suppliers
- Tel
- --
- Fax
- --
- sy-ec-marketing@synthesia.cz
- Country
- Czech Republic
- ProdList
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- Advantage
- 68
View Lastest Price from 2-(3-Amino-4-chloro-benzoyl)benzoic acid manufacturers
- Product
- 2-(3-Amino-4-chlorobenzoyl)benzoic acid 118-04-7
- Price
- US $153.49/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 98.00%HPLC
- Supply Ability
- 1.5tons/month
- Release date
- 2021-09-23
- Product
- 2-(3-Amino-4-chloro-benzoyl)benzoic acid 118-04-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-24