ChemicalBook > CAS DataBase List > 2-(3-THIENYL)ETHANAMINE

2-(3-THIENYL)ETHANAMINE

Product Name: 2-(3-THIENYL)ETHANAMINE
CAS No.: 59311-67-0
Chemical Name: 2-(3-THIENYL)ETHANAMINE
Synonyms: RARECHEM AL BW 0259;2-(3-THIENYL)ETHANAM;3-Thiopheneethanamine;2-(3-THIENYL)ETHAMINE;Thiophene-3-Ethylamine;Rotigotine Impurity 31;2-(3-THIENYL)ETHANAMINE;2-(3-Thienyl)ethylamine;42-(3-THIENYL)ETHANAMINE;2-(thien-3-yl)-ethylaMine
CBNumber: CB6285685
Molecular Formula: C6H9NS
Formula Weight: 127.21
MOL File: 59311-67-0.mol

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2-(3-THIENYL)ETHANAMINE Property

Boiling point:: 60-62 °C(Press: 2-3 Torr)
Density: 1.086 g/cm3
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.02±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H9NS/c7-3-1-6-2-4-8-5-6/h2,4-5H,1,3,7H2
InChIKey: OANLWIQYRRVBPY-UHFFFAOYSA-N
SMILES: C1SC=CC=1CCN

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T430268
Product name: 2-(Thiophen-3-yl)ethanamine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T430268
Product name: 2-(Thiophen-3-yl)ethanamine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

TRC

Product number: T430268
Product name: 2-(Thiophen-3-yl)ethanamine
Packaging: 500mg
Price: $310
Updated: 2021/12/16

AK Scientific

Product number: 8829AB
Product name: 2-(3-Thienyl)ethanamine
Packaging: 250mg
Price: $157
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-1-68
Product name: 2-(Thiophen-3-yl)ethan-1-amine
Packaging: 1g
Price: $495
Updated: 2021/12/16

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2-(3-THIENYL)ETHANAMINE Chemical Properties,Usage,Production

Synthesis

13781-53-8

59311-67-0

General procedure for the synthesis of 3-aminoethylthiophene from 3-thiophene acetonitrile: the synthesis was carried out according to the literature method. A rubber septum and stir bar were added to a pre-cooled and oven-dried 25 mL round-bottomed flask under argon protection, followed by the addition of anhydrous InCl3 (0.681 g, 3.079 mmol), anhydrous THF (10 mL) and NaBH4 (0.341 g, 9.014 mmol). The reaction mixture was stirred at 25 °C for 1 h. Then 3-thiophene acetonitrile (0.340 mL, 2.981 mmol) was slowly added dropwise and stirring was continued for 16 h at 25 °C. Upon completion of the reaction, the reaction was quenched with 10 mL of 2.8 M hydrochloric acid solution and the mixture was refluxed for 2 hours to dissolve the residual metal salt. After cooling to 25 °C, 5 mL of methanol was added and refluxed again for 2 hours. The reaction mixture was cooled to 25 °C, filtered and the filtrate was evaporated to remove the methyl borate and methanol. The remaining acidic aqueous solution was extracted with DCM (3 x 10 mL) and the organic layer was discarded. The acidic aqueous layer was adjusted to pH ≈ 11 with NaOH pellets and extracted again with DCM (3 × 10 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and the solvent evaporated in vacuum to give 2-(3-thienyl)ethylamine as a yellow oil (0.250 g, 67% yield).1H NMR (300 MHz, CDCl3) data were as follows: δ = 7.20-7.30 (m, 1H, ArH), 7.00 (m, 1H, ArH), 6.95 (m. 1H, ArH), 2.96 (t, 2H, J=6.6 Hz, CH2), 2.78 (t, 2H, J=6.6 Hz, CH2), 1.45 ppm (bs, 2H, NH2).The 1H NMR spectra were in agreement with the literature reports.

References

[1] Journal of Organic Chemistry, 2012, vol. 77, # 1, p. 221 - 228
[2] Tetrahedron Letters, 2013, vol. 54, # 45, p. 6087 - 6089
[3] MedChemComm, 2015, vol. 6, # 9, p. 1679 - 1686
[4] Journal of the American Chemical Society, 1954, vol. 76, p. 4466
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 351

2-(3-THIENYL)ETHANAMINE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Nitromethane Sodium 3-Thiophenecarboxaldehyde Tetrahydrofuran Diethyl ether Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Methanol Sodium hydroxide Magnesium sulfate Celite

Preparation Products

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59311-67-0, 2-(3-THIENYL)ETHANAMINERelated Search:

L-3-BENZOTHIENYLALANINE THIOPHENE-3-ACETIC ACID HYDRAZIDE 2-(3-THIENYL)ETHANAMINE 2,4,5-TRIMETHOXYBENZOIC ACID 2,3-BIS(2,4,5-TRIMETHYL-3-THIENYL)MALEIMIDE N-METHYL-1-(2-THIENYL)ETHANAMINE 2-(2-Thienyl)ethanamine (S)-N-Fmoc-3-Thienylalanine L-3-THIENYLALANINE BOC-D-3-BENZOTHIENYLALANINE FMOC-D-3-THIENYLALANINE 3-THIOPHENEPROPIONIC ACID METHYL 2-AMINO-6-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C] PYRIDINE-3-CARBOXYLATE D-3-THIENYLALANINE 2-AMINO-6-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE 2-(3-METHYL-2-THIENYL)ETHANAMINE 2-(5-METHYL-2-THIENYL)ETHANAMINE 2-METHOXY-2-(2-THIENYL)ETHANAMINE

2-(3-THIENYL)ETHANAMINE

2-THIOPHEN-3-YL-ETHYLAMINE

RARECHEM AL BW 0259

1-(3-thiophenyl)ethanamine

2-(3-Thienyl)ethylamine

3-Thiopheneethanamine

Thiophene-3-Ethylamine

2-(thien-3-yl)-ethylaMine

2-(Thiophen-3-yl)ethanaMine HCl

2-(3-THIENYL)ETHAMINE

42-(3-THIENYL)ETHANAMINE

2-(3-THIENYL)ETHANAMINE ISO 9001：2015 REACH

2-(3-THIENYL)ETHANAM

Rotigotine Impurity 31

59311-67-0

CHIRAL CHEMICALS

Thiophene