BUSERELIN

ChemicalBook > CAS DataBase List > BUSERELIN

Product Name: BUSERELIN
CAS No.: 57982-77-1
Chemical Name: BUSERELIN
Synonyms: hoe766a;receptal;Suprefact;BUSERELIN;Buserilin;etilamide;ici123215;Buserelin CRS;Buserelina(net);BUSERELIN PH. EUR.
CBNumber: CB6287694
Molecular Formula: C60H86N16O13
Formula Weight: 1239.42
MOL File: 57982-77-1.mol

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BUSERELIN Property

alpha: D20 -40.4° (c = 1 in dimethylacetamide)
Boiling point:: 845.19°C (rough estimate)
Density: 1.0711 (rough estimate)
refractive index: 1.6200 (estimate)
solubility: Sparingly soluble in water and in dilute acids.
pka: 9.82±0.15(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)
InChIKey: CUWODFFVMXJOKD-UHFFFAOYSA-N
SMILES: N1(CCCC1C(NCC)=O)C(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CO)NC(=O)C(CC1C2C=CC=CC=2NC=1)NC(=O)C(CC1=CNC=N1)NC(=O)C1CCC(=O)N1

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Safety

HS Code: 2937190000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H302Harmful if swallowed
Precautionary statements: P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD109219
Product name: (Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt
Packaging: 5mg
Price: $131
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109219
Product name: (Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt
Packaging: 10mg
Price: $228
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005431
Product name: BUSERELIN
Purity: 95.00%
Packaging: 1MG
Price: $242.55
Updated: 2021/12/16

Apolloscientific

Product number: BITH3005
Product name: Buserelin
Packaging: 5mg
Price: $399
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109219
Product name: (Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt
Packaging: 25mg
Price: $456
Updated: 2021/12/16

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BUSERELIN Chemical Properties,Usage,Production

Description

Buserelin (Suprefact?) is a hormonal therapy drug used to treat advanced prostate cancer. It is a medication which is used primarily in the treatment of prostate cancer and endometriosis. It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy. In addition, buserelin is used in veterinary medicine. The medication is typically used as a nasal spray three times per day, but is also available for use as a solution or implant for injection into fat.

Chemical Properties

White or slightly yellowish powder, hygroscopic.

Uses

Gonad-stimulating principle.

Definition

ChEBI: Buserelin is an oligopeptide.

brand name

Suprefact (Hoechst-Roussel).

Clinical Use

Treatment of advanced prostate cancer and endometriosis

Pituitary desensitisation in preparation for ovulation induction regimens using gonadotrophins

Side effects

Using too much Buserelin Injection may make you feel weak, nervous, dizzy and sick. You may also have a headache, hot flushes, stomach pain, swelling of the legs and breast pain. You may also have pain, bleeding or hardening of the skin at the site of injection

Metabolism

Metabolic inactivation by peptides occurs in the liver and kidney. The drug is also inactivated by pituitary membrane enzymes. Excreted in the urine and bile as unchanged drug and metabolites.

BUSERELIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BUSERELIN manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: BUSERELIN 57982-77-1
Price: US $840.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1kg
Release date: 2021-06-07

Hebei Yanxi Chemical Co., Ltd.

Product: BUSERELIN 57982-77-1
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-18

Wuhan Cell Pharmaceutical Co., Ltd

Product: BUSERELIN 57982-77-1
Price: US $9.90-9.90/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-04-07

57982-77-1, BUSERELINRelated Search:

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(d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide

(d-ser(tbu)(sup6)-ea(sup10))-lhrh

(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon

(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone

BUSERELIN

1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-

Buserilin

BUSERELIN PH. EUR.

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt

Suprefact

Buserelin, Buserelina

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Buserilin,1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-

(Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2

d-ser(tbu(sup6))-lh-rh-(1-9)-nonapeptideethylamide

d-ser-(tbu)(sup6)-lhrh-ethylamide

etilamide

hoe766a

ici123215

luteinizinghormone-releasinghormone(pig),6-(o-(1,1-dimethylethyl)-d-serine)

receptal

P-GLU-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET

PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET

(DES-GLY10,D-SER(TBU)6,PRO-NHET9)-LHRH

Buserelin CRS

BuserelinQ: What is Buserelin Q: What is the CAS Number of Buserelin Q: What is the storage condition of Buserelin

Buserelina(net)

57982-77-1

C60H86N16O13

BioChemical

Amino Acids and Peptides

Biochemicals and Reagents

Releasing Factors

Peptides

LH-RH

hormones

57982-77-1