R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
- Product Name
- R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
- CAS No.
- 67287-39-2
- Chemical Name
- R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
- Synonyms
- SKF 81297C;SKF-81297 HBr;R(+)-SKF-81297 HYDROBROMIDE;9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol:hydrobromide;(R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide;R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
- CBNumber
- CB6294186
- Molecular Formula
- C16H17BrClNO2
- Formula Weight
- 370.67
- MOL File
- 67287-39-2.mol
R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Property
- Melting point:
- >256°C (dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- H2O: 6 mg/mL
- form
- solid
- color
- white to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 15067
- Product name
- (±)-SKF 81297 (hydrobromide)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 15067
- Product name
- (±)-SKF 81297 (hydrobromide)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 15067
- Product name
- (±)-SKF 81297 (hydrobromide)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $218
- Updated
- 2024/03/01
- Product number
- S550020
- Product name
- SKF81297C
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- B6744
- Product name
- SKF81297hydrobromide
- Packaging
- 25mg
- Price
- $247
- Updated
- 2021/12/16
R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Chemical Properties,Usage,Production
Uses
SKF 81297C is a dopamine D1 agonist (1).
Hazard
A poison.
Biological Activity
skf 81297 hydrobromide is a selective agonist of the dopamine d1-like receptor, with a ki value of 1.9 nm. the dopamine d1-like receptors, consisting of d1 and d5 subtypes, are a subfamily of dopamine receptors that mediate excitatory neurotransmission after binding the endogenous neurotransmitter dopamine. the dopamine d1-like receptors have been implicated in dopaminergic regulation of a variety of fundamental neurophysiologic processes including mood, motivation, cognitive function, as well as motor activity.1. neumeyer jl, kula ns, bergman j, baldessarini rj. receptor affinities of dopamine d1 receptor-selective novel phenylbenzazepines. european journal of pharmacology, 2003, 474(2-3): 137-140.2. undieh as. pharmacology of signaling induced by dopamine d(1)-like receptor activation. pharmacology & therapeutics, 2010, 128(1): 37-60.3. vermeulen rj, drukarch b, sahadat mc, et al. the dopamine d1 agonist skf 81297 and the dopamine d2 agonist ly 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys. movement disorders, 1994, 9(6): 664-672.
storage
+4°C (desiccate)
R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Suppliers
- Tel
- --
- Fax
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- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
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