ChemicalBook > CAS DataBase List > Isomannide

Isomannide

Product Name: Isomannide
CAS No.: 641-74-7
Chemical Name: Isomannide
Synonyms: 1,4;(3R,3aR,6R,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol;1,4:3,6-DIANHYDRO-D-MANNITOL;Isomaide;ISOMANNIDE;D-Isomannide;Isomannide>Isomannide,98%;Keratin 5 &1,4:3,6-Dianhydro-D-
CBNumber: CB6298311
Molecular Formula: C6H10O4
Formula Weight: 146.14
MOL File: 641-74-7.mol

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Isomannide Property

Melting point:: 80-85 °C (lit.)
alpha: 89 º (c=3, H2O)
Boiling point:: 150 °C / 12mmHg
Density: 1.0945 (rough estimate)
refractive index: 1.4128 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly), Water
form: Solid
pka: 13.17±0.40(Predicted)
color: White to Off-White
optical activity: [α]25/D +89°, c = 3 in H2O
Water Solubility: almost transparency
BRN: 80509
CAS DataBase Reference: 641-74-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10-21
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 329266
Product name: 1,4:3,6-Dianhydro-D-mannitol
Purity: 95%
Packaging: 25g
Price: $83.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 329266
Product name: 1,4:3,6-Dianhydro-D-mannitol
Purity: 95%
Packaging: 100g
Price: $274
Updated: 2025/07/31

TCI Chemical

Product number: I0406
Product name: Isomannide
Purity: >98.0%(GC)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: I0406
Product name: Isomannide
Purity: >98.0%(GC)
Packaging: 25g
Price: $82
Updated: 2025/07/31

TRC

Product number: D415960
Product name: 1,4:3,6-Dianhydro-D-mannitol
Packaging: 25g
Price: $80
Updated: 2021/12/16

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Isomannide Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

1,4:3,6-Dianhydro-D-mannitol is a reagent used in the synthesis of new isomannide-based peptidomimetic as human tissue kallikrein 1 inhibitor using Ugi multicomponent reaction. It also functions as a chiral ligand for stereoselective synthesis.

Synthesis

69-65-8

641-74-7

The general procedure for the synthesis of 1,4:3,6-bis-anhydromannitol from D-mannitol was as follows: 1350 g of crystalline D-mannitol was added to a reduced-pressure reactor equipped with a stirrer and heated to 170 °C to melt it. Subsequently, 10 g of 98% concentrated sulfuric acid was added to the melt, and the reaction lasted for 20 h at 170 °C and 2 kPa with nitrogen gas being passed at a flow rate of 200 mL/min. Upon completion of the reaction, the product was cooled to 90 °C and 30 g of 48% (w/w) aqueous sodium hydroxide solution was added to give crude 1,4:3,6-bis-anhydromannitol. Next, 39 g of horseshoe-based wood activated carbon (trade name: Tyco K, produced by Futamura Chemical Co., Ltd.) was added to the crude product and stirred for 3 h for decolorization to obtain a mixture to be distilled. Water was distilled from the mixture at 120 °C and 5 kPa. Subsequently, a reduced pressure distillation was carried out at 170 °C and 0.3 kPa under reduced pressure by passing nitrogen at a flow rate of 200 mL/min, resulting in 491 g of product. A portion of the distilled product was taken and the pH of the mixture was determined to be 10 according to the method of Example 1.

References

[1] Green Chemistry, 2015, vol. 17, # 2, p. A1176 - A1185
[2] Journal of Chemical Crystallography, 1997, vol. 27, # 3, p. 161 - 166
[3] Carbohydrate Research, 1980, vol. 79, p. 133 - 141
[4] Journal of Organometallic Chemistry, 1983, vol. 253, # 2, p. 249 - 252
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 930,934

Isomannide Preparation Products And Raw materials

Raw materials

Sorbitol

Preparation Products

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View Lastest Price from Isomannide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Isomannide 641-74-7
Price: US $120.00-1200.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 200tons
Release date: 2025-08-19

Honest Joy Holdings Limited

Product: Isomannide 641-74-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.8%
Supply Ability: 100 tons
Release date: 2022-02-21

Career Henan Chemical Co

Product: Isomannide 641-74-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

641-74-7, IsomannideRelated Search:

Mannitol D-Mannitol D-Mannose Isomannide mononitrate dianhydromannitol Dianhydromannitol monooleate ISOMANNIDE = 1,4:3,6-DIANHYDROMANNITOL,ISOMANNIDE = 1,4:3,6-DIANHYDROMANNITOL Isomannide dinitrate Isomannide

1,4:3,6-DIANHYDROMANNITOL

ISOMANNIDE

1,4

Perhydro-3,6-dihydroxyfuro[3,2-b]furan

Keratin 5 &amp

Milnacipran Impurity 14

(3R,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol

I**isomannide、1,4:3,6-dianhydro-D-manni

3-Nitro-4-hydroxy diphenyl

Isomannide,98%

3,6-Dianhydro-D-mannitol

3-NITRO-HYDROXYDIPHENYL

1,4,3,6-Dianhydro-D-mannitolIsomannide

4,8-Dioxabicyclo[3.3.0]octane-2,6-diol

(3aα,6aα)-Hexahydrofuro[3,2-b]furan-3β,6β-diol

(3R,3aα,6aα)-Hexahydrofuro[3,2-b]furan-3β,6β-diol

1,4:3,6-DIANHYDRO-D-MANNITOL

2,3,3aα,5,6,6aα-Hexahydrofuro[3,2-b]furan-3β,6β-diol

D-Isomannide

1,4:3,6-Dianhydro-D-mannitol ,98%

1,4:3,6-Dianhydro-D-

Isomaide

D-Mannitol, 1,4:3,6-dianhydro-

(1R,2R,3S,4R)-1-((2R,3S,4S,5S)-3,4,5,6-Tetrahydroxytetrahydro-2H-pyran-2-yl)pentane-1,2,3,4,5-pentaol

(3R,3aR,6R,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol

(1R,2R,3S,4R)-1-((2R,3S,4S,5S)-3,4,5,6-Tetrahydroxytetrahydro-2H-pyran-2-yl)pentane-1,2,3,4,5-pen

(1R,2R,3S,4R)-1-((2R,3S,4S,5S)-3,4,5,6-Tetrahydroxytetrahydro-2H-pyran-2-yl)pentane-1,2,3,4,5-

Voronazan Fumarate Impurity 14

Isomannide&gt

Myeloid-related portein8

Isomannide USP/EP/BP

1,4:3,6-Dianhydrohexitol

Refametinib Impurity 2

1,4:3,6-Dianhydro-<sc>D</sc>-mannitol

Double dehydrated mannitol

6-Dianhydro-D-mannitol

641-74-7

Carbohydrate Synthesis

Monosaccharides

Specialty Synthesis

Alcohols and Derivatives

Heterocycles

Glycon Biochem