Isomannide
- Product Name
- Isomannide
- CAS No.
- 641-74-7
- Chemical Name
- Isomannide
- Synonyms
- 1,4;(3R,3aR,6R,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol;1,4:3,6-DIANHYDRO-D-MANNITOL;Isomaide;ISOMANNIDE;D-Isomannide;Isomannide>Isomannide,98%;Keratin 5 &1,4:3,6-Dianhydro-D-
- CBNumber
- CB6298311
- Molecular Formula
- C6H10O4
- Formula Weight
- 146.14
- MOL File
- 641-74-7.mol
Isomannide Property
- Melting point:
- 80-85 °C (lit.)
- alpha
- 89 º (c=3, H2O)
- Boiling point:
- 150 °C / 12mmHg
- Density
- 1.0945 (rough estimate)
- refractive index
- 1.4128 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly), Water
- form
- Solid
- pka
- 13.17±0.40(Predicted)
- color
- White to Off-White
- optical activity
- [α]25/D +89°, c = 3 in H2O
- Water Solubility
- almost transparency
- BRN
- 80509
- CAS DataBase Reference
- 641-74-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 329266
- Product name
- 1,4:3,6-Dianhydro-D-mannitol
- Purity
- 95%
- Packaging
- 25g
- Price
- $83.5
- Updated
- 2025/07/31
- Product number
- 329266
- Product name
- 1,4:3,6-Dianhydro-D-mannitol
- Purity
- 95%
- Packaging
- 100g
- Price
- $274
- Updated
- 2025/07/31
- Product number
- I0406
- Product name
- Isomannide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- I0406
- Product name
- Isomannide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- D415960
- Product name
- 1,4:3,6-Dianhydro-D-mannitol
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
Isomannide Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
1,4:3,6-Dianhydro-D-mannitol is a reagent used in the synthesis of new isomannide-based peptidomimetic as human tissue kallikrein 1 inhibitor using Ugi multicomponent reaction. It also functions as a chiral ligand for stereoselective synthesis.
Synthesis
69-65-8
641-74-7
The general procedure for the synthesis of 1,4:3,6-bis-anhydromannitol from D-mannitol was as follows: 1350 g of crystalline D-mannitol was added to a reduced-pressure reactor equipped with a stirrer and heated to 170 °C to melt it. Subsequently, 10 g of 98% concentrated sulfuric acid was added to the melt, and the reaction lasted for 20 h at 170 °C and 2 kPa with nitrogen gas being passed at a flow rate of 200 mL/min. Upon completion of the reaction, the product was cooled to 90 °C and 30 g of 48% (w/w) aqueous sodium hydroxide solution was added to give crude 1,4:3,6-bis-anhydromannitol. Next, 39 g of horseshoe-based wood activated carbon (trade name: Tyco K, produced by Futamura Chemical Co., Ltd.) was added to the crude product and stirred for 3 h for decolorization to obtain a mixture to be distilled. Water was distilled from the mixture at 120 °C and 5 kPa. Subsequently, a reduced pressure distillation was carried out at 170 °C and 0.3 kPa under reduced pressure by passing nitrogen at a flow rate of 200 mL/min, resulting in 491 g of product. A portion of the distilled product was taken and the pH of the mixture was determined to be 10 according to the method of Example 1.
References
[1] Green Chemistry, 2015, vol. 17, # 2, p. A1176 - A1185
[2] Journal of Chemical Crystallography, 1997, vol. 27, # 3, p. 161 - 166
[3] Carbohydrate Research, 1980, vol. 79, p. 133 - 141
[4] Journal of Organometallic Chemistry, 1983, vol. 253, # 2, p. 249 - 252
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 930,934
Isomannide Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
- Tel
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- info@dottikon.com
- Country
- Switzerland
- ProdList
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View Lastest Price from Isomannide manufacturers
- Product
- Isomannide 641-74-7
- Price
- US $120.00-1200.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 200tons
- Release date
- 2025-08-19
- Product
- Isomannide 641-74-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- Isomannide 641-74-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25