3-PYRIMIDIN-5-YL-BENZOIC ACID
- Product Name
- 3-PYRIMIDIN-5-YL-BENZOIC ACID
- CAS No.
- 852180-74-6
- Chemical Name
- 3-PYRIMIDIN-5-YL-BENZOIC ACID
- Synonyms
- P-017;3-(2-Methoxyp;AKOS BAR-0650;3-PYRIMIDIN-5-YL-BENZOIC ACID;3-(5-PYRIMIDINYL)BENZOIC ACID;3-PYRIMIDIN-5-YL-BENZOIC ACID, 95+%;Benzoic acid, 3-(5-pyrimidinyl)- (9CI);3-(2-Chloropyrimidin-5-yl)benzoic acid;3-(2,4-Dimethoxypyrimidin-5-yl)benzoic acid;3-(2-(Methylthio)pyrimidin-5-yl)benzoic acid
- CBNumber
- CB6299464
- Molecular Formula
- C11H8N2O2
- Formula Weight
- 200.19
- MOL File
- 852180-74-6.mol
3-PYRIMIDIN-5-YL-BENZOIC ACID Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- color
- Off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P997398
- Product name
- 3-Pyrimidin-5-yl-benzoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR913118
- Product name
- 3-Pyrimidin-5-ylbenzoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- W8798
- Product name
- 3-Pyrimidin-5-yl-benzoicacid
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR913118
- Product name
- 3-Pyrimidin-5-ylbenzoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 071828
- Product name
- 3-Pyrimidin-5-yl-benzoic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $759
- Updated
- 2021/12/16
3-PYRIMIDIN-5-YL-BENZOIC ACID Chemical Properties,Usage,Production
Synthesis
4595-59-9
269409-73-6
852180-74-6
General method: 5-Bromopyrimidine (1.0 eq.) was dissolved in a solvent mixture of water and dioxane (1:1). Subsequently 3-carboxyphenylboronic acid pinacol ester (1.5 eq.) and potassium phosphate (5.0 eq.) were added. The reaction solution was degassed by vacuum/argon cycle (10 times) and further degassed (5 times) before addition of PdCl2(PPh3)2 (10 mol%). The resulting mixture was stirred and reacted at 95 °C and under argon protection for 16-20 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and diluted with about 30 mL of water and subsequently washed with chloroform (3 x 30 mL). Unless otherwise indicated, the aqueous phase was concentrated under reduced pressure and purified by C18 pre-column and further eluted on a 10g or 60g C18 column using gradient elution with aqueous acetonitrile (10-100%) to obtain the target product 3-pyrimidine-5-benzene carboxylic acid.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 634 - 648
[2] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 80
3-PYRIMIDIN-5-YL-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-PYRIMIDIN-5-YL-BENZOIC ACID Suppliers
- Tel
- --
- Fax
- --
- synthesis@chimmed.ru
- Country
- Russia
- ProdList
- 5006
- Advantage
- 81
View Lastest Price from 3-PYRIMIDIN-5-YL-BENZOIC ACID manufacturers
- Product
- 3-Pyrimidin-5-ylbenzoic acid 852180-74-6
- Price
- US $1.00-1.00/Kg/Drum
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2020-05-14
- Product
- 3-PYRIMIDIN-5-YL-BENZOIC ACID 852180-74-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-17