ChemicalBook > CAS DataBase List > 2,6-DIMETHYLANILINE HYDROCHLORIDE

2,6-DIMETHYLANILINE HYDROCHLORIDE

Product Name
2,6-DIMETHYLANILINE HYDROCHLORIDE
CAS No.
21436-98-6
Chemical Name
2,6-DIMETHYLANILINE HYDROCHLORIDE
Synonyms
Einecs 244-388-1;CompoundAR0033QU;ROPIVACAINE RC A;Compound AR0033QU;Lidocaine Impurity 50;Ropivacaine Impurity A;2,6-DimethylanilineHCl;2,6-xylidinium chloride;Bupivacaine EP Impurity F;2,6-XYLIDINE HYDROCHLORIDE
CBNumber
CB6299479
Molecular Formula
C8H12ClN
Formula Weight
157.64
MOL File
21436-98-6.mol
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2,6-DIMETHYLANILINE HYDROCHLORIDE Property

Melting point:
275°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
powder or crystals
color 
White to Pale Brown
Stability:
Hygroscopic
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
RTECS 
ZF0375000
HS Code 
2921490002
Toxicity
rat,LD50,oral,2042mg/kg (2042mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 167, Pg. 223, 1969.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901252
Product name
2,6-Dimethylaniline hydrochloride
Purity
≥98%
Packaging
1G
Price
$44.2
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR2572
Product name
Ropivacaine Related Compound A
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$557
Updated
2025/07/31
Sigma-Aldrich
Product number
901252
Product name
2,6-Dimethylaniline hydrochloride
Purity
≥98%
Packaging
5G
Price
$121
Updated
2025/07/31
Sigma-Aldrich
Product number
1605512
Product name
Ropivacaine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1470
Updated
2025/07/31
TCI Chemical
Product number
X0029
Product name
2,6-Dimethylaniline Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$172
Updated
2025/07/31
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2,6-DIMETHYLANILINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

2,6-Dimethylaniline hydrochloride may be used in the preparation of 2,6-dimethylphenyl isocyanate via phosgenation. This product was previously listed as CDS000447.

Synthesis

2198-53-0

925-90-6

21436-98-6

The general procedure for the synthesis of 2,6-dimethylaniline hydrochloride from 2,6-dimethylacetanilide and ethylmagnesium bromide was as follows: trifluoromethanesulfonic anhydride (Tf2O, 185 μL, 1.1 mmol) was added slowly and dropwise to a cooled-to-0°C dichloromethane ( 4 mL) solution. The reaction mixture was stirred at 0 °C for 30 min, then transferred to -78 °C and a solution of tetrahydrofuran (THF, 15 mL) of freshly prepared organocerium reagent/complex (3.0 mmol) was added, and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of a 3 mol/L aqueous hydrochloric acid solution (5 mL) and the mixture was gradually warmed to room temperature with continued stirring for 2 hours. Subsequently, 25% ammonium hydroxide solution (5 mL) was added to the mixture. The organic layer was separated and the aqueous phase was extracted with ether (3 x 10 mL). The organic layers were combined, washed with saturated saline (3 x 3 mL) and concentrated under reduced pressure to about 1/3 of the original volume. the residual organic phase was extracted with 3 mol/L aqueous hydrochloric acid solution (3 x 5 mL). The separated organic phase was washed with saturated saline (5 mL), dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure, and the residue was purified by silica gel fast column chromatography to obtain the target ketone product. All aqueous phases were combined, washed with ether (5 mL) and alkalized with 25% ammonium hydroxide solution (5 mL), then back-extracted with ether (5×20 mL). The ether layers were combined, washed with saturated saline (5 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and acidified with 3 mol/L ethyl acetate hydrochloride solution (5 mL), and finally concentrated under reduced pressure to give 2,6-dimethylaniline hydrochloride.

References

[1] Chinese Chemical Letters, 2015, vol. 26, # 9, p. 1055 - 1058

2,6-DIMETHYLANILINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-DIMETHYLANILINE HYDROCHLORIDE manufacturers

Moxin Chemicals
Product
Ropivacaine EP Impurity H(Hydrochloride) 21436-98-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
99%+ HPLC
Supply Ability
1000
Release date
2025-07-02
Apeloa production Co.,Limited
Product
2,6-Dimethylaniline Hydrochloride 21436-98-6
Price
US $1.00/g
Min. Order
1g
Purity
0.98
Supply Ability
1000
Release date
2024-07-18
Career Henan Chemical Co
Product
2,6-DIMETHYLANILINE HYDROCHLORIDE 21436-98-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 tons
Release date
2020-01-10

21436-98-6, 2,6-DIMETHYLANILINE HYDROCHLORIDERelated Search:

2',6'-Pipecoloxylidide Bupivacaine-d9 4-Hydroxy-N-desbutyl Bupivacaine Bupivacaine Impurity 1-Butyl-1-oxido-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride Bupivacaine Impurity Linocaine hydrochloride Alachlor 2-Chloro-N-(2,6-dimethylphenyl)acetamide 5-CHLORO-7-METHYLISATIN 4-Chloro-7-methylisatin 4,4'-Carbonimidoylbis(N,N-dimethylaniline) hydrochloride 2,4-DIMETHYLANILINE HYDROCHLORIDE 98+%,2,4-DIMETHYLANILINE HYDROCHLORIDE N,N-DIMETHYLANILINE HYDROCHLORIDE 4-CHLORO-2,6-DIMETHYLANILINE HYDROCHLORIDE 3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE 6-CHLORO-7-METHYL ISATIN AKOS BBS-00003981

  • 2,6-XYLIDINE HYDROCHLORIDE
  • 2,6-DIMETHYLANILINE HYDROCHLORIDE
  • 2,6-xylidinium chloride
  • 2,6-DimethylanilineHCl
  • Einecs 244-388-1
  • Ropivacaine Related Compound A (25 mg) (2,6-dimethylaniline hydrochloride)
  • Ropivacaine Related CoMpound A
  • Ropivacaine Impurity A
  • 2,6-DIMETHYLANILINE HYDROCHLORIDE 98+%
  • Bupivacaine EP Impurity F HCl (Ropivacaine EP Impurity H HCl)
  • Bupivacaine EP Impurity F HCl
  • Ropivacaine EP Impurity H HCl
  • Ropivacaine EP Impurity H HCl (Bupivacaine EP Impurity F HCl)
  • Bupivacaine EP Impurity F
  • 2,-6-Dimethylaniline Hydrochloride Certified Reference Standard
  • Ropivacaine RC A / Ropivacaine EP Impurity H
  • Ropivacaine Related Compound A.HCl
  • Ropivacaine Related Compound A (2,6-dimethylaniline hydrochloride) (1605512)
  • Ropivacaine Related Compound A as Hydrochloride
  • Ropivacaine USP Related Compound A as Hydrochloride
  • Compound AR0033QU
  • CompoundAR0033QU
  • Lidocaine Hydrochloride Impurity A as Hydrochloride
  • Lidocaine EP Impurity A(Bupivacaine EP Impurity F
  • Lidocaine Hydrochloride EP Impurity A as Hydrochloride
  • Bupivacaine EP Impurity F(Ropivacaine EP Impurity H HCl)
  • Lidocaine Impurity 50
  • ROPIVACAINE RC A
  • Dapagliflozin Impurity 125
  • Lidocaine EP Impurity A HCl
  • Lidocaine EP Impurity A HCl (Bupivacaine EP Impurity F HCl, Ropivacaine EP Impurity H HCl, Ropivacaine USP Related Compound A)
  • ROPIVACAINE RELATED COMPOUND A (2LOTS)
  • Ropivacaine EP Impurity H(Hydrochloride)
  • 21436-98-6
  • C8H11NHCl