2-Chloro-N-(2,6-dimethylphenyl)acetamide

Product Name: 2-Chloro-N-(2,6-dimethylphenyl)acetamide
CAS No.: 1131-01-7
Chemical Name: 2-Chloro-N-(2,6-dimethylphenyl)acetamide
Synonyms: Lidocaine EP Impurity H;NSC 37260;2-Chloro-N-(2;acetoxylidide;AKOS BBS-00000875;LIDOCAINE EP IMP H;TIMTEC-BB SBB003566;IFLAB-BB F0133-0019;Chloroacet-2,6-xylide;CHLORO ACETYL XYLIDIDE
CBNumber: CB0151081
Molecular Formula: C10H12ClNO
Formula Weight: 197.66
MOL File: 1131-01-7.mol

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2-Chloro-N-(2,6-dimethylphenyl)acetamide Property

Melting point:: 150-151 °C(lit.)
Boiling point:: 316.8±30.0 °C(Predicted)
Density: 1.1363 (rough estimate)
refractive index: 1.5330 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 12.91±0.70(Predicted)
form: Crystalline Powder or Needles
color: White to brown
Water Solubility: Soluble in Chloroform, Methanol. Insoluble in water.
BRN: 781309
Stability:: Light Sensitive
InChIKey: FPQQSNUTBWFFLB-UHFFFAOYSA-N
CAS DataBase Reference: 1131-01-7(CAS DataBase Reference)
NIST Chemistry Reference: 2-Chloro-2',6'-acetoxylidide(1131-01-7)
EPA Substance Registry System: Acetamide, 2-chloro-N-(2,6-dimethylphenyl)- (1131-01-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1673
Product name: N-(2,6-Dimethylphenyl)chloroacetamide
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 100mg
Price: $704.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 194921
Product name: N-(2,6-Dimethylphenyl)chloroacetamide
Purity: 99%
Packaging: 10g
Price: $81.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1366080
Product name: Lidocaine Related Compound H
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50MG
Price: $1470
Updated: 2025/07/31

TCI Chemical

Product number: C2307
Product name: 2-Chloro-2',6'-dimethylacetanilide
Purity: >98.0%(GC)(N)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: C2307
Product name: 2-Chloro-2',6'-dimethylacetanilide
Purity: >98.0%(GC)(N)
Packaging: 25g
Price: $94
Updated: 2025/07/31

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2-Chloro-N-(2,6-dimethylphenyl)acetamide Chemical Properties,Usage,Production

Chemical Properties

beige needles or crystalline powder

Uses

Lidocaine intermediate.

Uses

2-Chloro-2',6'-dimethylacetanilide is used in the determination of the enantiomers of tocainide in blood plasma by gas-liquid chromatography with electron-capture detection. It is a nonsteroidal antinflammatory drug.

General Description

N-(2,6-Dimethylphenyl)chloroacetamide (2-chloro-2′,6′-acetoxylidide) is nonsteroidal antinflammatory drug.

Synthesis

593-71-5

28556-81-2

1131-01-7

General method: Chloroiodomethane (1.5 eq.) is slowly added to a solution of 2,6-dimethylphenyl isocyanate (1.0 eq.) in anhydrous ether (1 M concentration) at -78 °C. After 2 minutes of reaction, a 1.5 M solution of methyl lithium-lithium bromide (1.25 equiv.) ether was added dropwise over 5 minutes. Maintaining this temperature, the reaction mixture was stirred for the indicated time (see Table 1 and Scheme 2 for specific times). Upon completion of the reaction, aqueous ammonium chloride solution (2 mL/mmol substrate) was added, the cooling bath was removed, and stirring was continued until the mixture was brought to room temperature. Subsequently, the reaction mixture was extracted with ether (2 x 5 mL) and the organic phase was washed sequentially with water (5 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give pure 2,6-dimethylchloroacetanilide.

References

[1] Chemical Communications, 2013, vol. 49, # 75, p. 8383 - 8385
[2] Synthesis (Germany), 2014, vol. 46, # 21, p. 2897 - 2909

2-Chloro-N-(2,6-dimethylphenyl)acetamide Preparation Products And Raw materials

Raw materials

N-Methylaniline Anhydrous benzene Chloroacetyl chloride

Preparation Products

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2-Chloro-N-(2,6-dimethylphenyl)acetamide Suppliers

Americas 1 Belgium 4 Canada 4 China 276 Europe 1 France 2 Germany 6 India 44 Japan 5 Russia 1 South Korea 1 Switzerland 2 Ukraine 2 United Kingdom 13 United States 39 Global 401

Z IntellecChem& Tech. Co., Ltd

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Energy Chemical

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Capot Chemical Co., Ltd

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View Lastest Price from 2-Chloro-N-(2,6-dimethylphenyl)acetamide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-09-14

S&Y Biochem Co.,Ltd

Product: 2-Chloro-N-(2,6-dimethylphenyl)acetamide 1131-01-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98
Supply Ability: 1000
Release date: 2024-10-11

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Lidocaine EP Impurity H 1131-01-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-20

1131-01-7, 2-Chloro-N-(2,6-dimethylphenyl)acetamideRelated Search:

Chloroacetamide 4'-Nitroacetanilide 2-BENZOYLACETANILIDE 4'-Aminoacetanilide N,N-Dimethyl-1,4-phenylenediamine N-Acetylsulfanilyl chloride N,N-Dimethylaniline p-Acetotoluidide Acetaminophen Acetamide N,N-Dimethylacetamide Difluorochloromethane Metazachlor Machette Alachlor DIETHATYL ETHYL Metolachlor DIMETHACHLOR

Chloro-2',6'-diMethylacetanilide

2',6'-DiMethyl-2-chloroacetanilide

ChloroacetaMido-2,6-xylidine

N-(2,6-Xylyl)chloroacetaMide

NSC 37260

2-Chloro-N-(2,6-dimethylphenyl)acetamide2-Chloro-N-(2,6-dimethylphenyl)acetamide

2-Chloro-N-(2

6-diMethylphenyl)acetaMide

N-(2,6-Dimethylphenyl)chloroacetamide 99%

2-Chloro-N-(2,6-dimethylphenyl)acetamide 2-Chloro-2',6'-acetoxylidide

2',6'-Acetoxylidide, 2-chloro- (8CI)

2-chloro-N-(2,6-dimethylphenyl)ethanamide

acetoxylidide

N-(2,6-Dimethylphenyl)chloroacetamide

Lidocaine EP Impurity H

Lidocaine Impurity H(EP)

Lidocaine Impurity 8(Lidocaine EP Impurity H)

Lidocaine BP Impurity H

JR-8652, 2-Chloro-N-(2,6-dimethylphenyl)acetamide, 97%

2-Chlor-2',6'-dimethylacetanilid

Acetamide, 2-chloro-N-(2

1-Chloroacetylamino-2,6-dimethylbenzene

2',6'-Acetoxylidide, 2-chloro-

2-Chloro-2',6'-dimethylacetanilide

2-Chloroaceto-2,6-xylidide

2-chloro-n-(2,6-dimethylphenyl)-acetamid

Acetamide, 2-chloro-N-(2,6-dimethylphenyl)-

Chloroacet-2,6-xylide

Chloroaceto-2,6-xylidide

N-CHLOROACETYL-2,6-DIMETHYLANILINE

N-CHLORACETYL-2,6-DIMETHYLANILINE

TIMTEC-BB SBB003566

2-CHLORO-2',6'-ACETOXYLIDIDE

2-CHLORO-N-(2,6-DIMETHYLPHENYL)ACETAMIDE

AKOS BBS-00000875

CHLOROACETYL-2,6-DIMETHYLANILINE

IFLAB-BB F0133-0019

Chloroaceto-2,6-xylidide~alpha-Chloro-2,6-dimethylacetanilide

à-chloro-2,6-dimethylacetanilide

ALPHA-Chloro-2'',6''-dimethylacetanilide

N-(Chloroacetyl)-2,6-diethylaniline

2-Chlorl-N-(2,6-dimethylpheny)acetamide

2-CHLORO-2'',6''-DIMETHYLACETANILIDE (LIDOCAINE)

CHLORO ACETYL XYLIDIDE

2-Chloro-N-(2,6-dimethylphenyl)acetamide,98%

Lidocaine Impurity H Reference

2-Chloro-2',6'-dimethylacetanilide &gt

Lidocaine hydrochloride impurity888

LIDOCAINE HYDROCHLORIDE EP IMPURITY H

Lidocaine EP Impurity H（2-chloro-N-(2,6-dimethylphenyl)acetamide）

Lidocaine Related Compound H (2-Chloro-N-(2,6-dimethylphenyl)acetamide) (1366080)

10-PHENOXYPHENYLACETIC&ACID

Lidocaine USP Related Compound H

ChloroAcetyl Xylidine?(N-Chloroacetyl 2,6 Dimethylaniline)

2-Chloro-N-(2,6- dimethylphenyl)acet amide / CAX Base

2-Chloro-N - (2,6-xylenyl) acetamide

2-Chloro-2',6'-dimethylacetanilide, ≥ 98.0%

LIDOCAINE EP IMP H