ChemicalBook > CAS DataBase List > Mal-amido-PEG4-TFP ester
Mal-amido-PEG4-TFP ester
- Product Name
- Mal-amido-PEG4-TFP ester
- CAS No.
- 1807540-84-6
- Chemical Name
- Mal-amido-PEG4-TFP ester
- Synonyms
- Mal-NH-PEG4-TFP;Mal-amido-PEG4-TFP ester;Mal-NH-PEG4-CH2CH2COOTFP;2,3,5,6-tetrafluorophenyl 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oate;4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 2,3,5,6-tetrafluorophenyl ester
- CBNumber
- CB63062524
- Molecular Formula
- C24H28F4N2O9
- Formula Weight
- 564.48
- MOL File
- 1807540-84-6.mol
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Mal-amido-PEG4-TFP ester Property
- storage temp.
- -20°C, sealed storage, away from moisture
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Viscous Liquid
- color
- Colorless to light yellow
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-22740
- Product name
- Mal-amido-PEG4-TFPester
- Purity
- 95%
- Packaging
- 250mg
- Price
- $220
- Updated
- 2021/12/16
dPEG
- Product number
- 10551
- Product name
- MAL-dPEG®₄-TFPester
- Packaging
- 1000mg
- Price
- $250
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22740
- Product name
- Mal-amido-PEG4-TFPester
- Purity
- 95%
- Packaging
- 1g
- Price
- $380
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIPG1485
- Product name
- Mal-amido-PEG4-TFP ester
- Packaging
- 250mg
- Price
- $428
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22740
- Product name
- Mal-amido-PEG4-TFPester
- Purity
- 95%
- Packaging
- 5G
- Price
- $1330
- Updated
- 2021/12/16
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Mal-amido-PEG4-TFP ester Chemical Properties,Usage,Production
Description
Mal-amido-PEG4-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.
Uses
Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
Mal-amido-PEG4-TFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mal-amido-PEG4-TFP ester manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Mal-amido-PEG4-TFP ester 1807540-84-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-27