Cyclic Arg-Gly-Asp-D-Tyr-Lys

Product Name: Cyclic Arg-Gly-Asp-D-Tyr-Lys
CAS No.: 250612-42-1
Chemical Name: Cyclic Arg-Gly-Asp-D-Tyr-Lys
Synonyms: Cyclo(RGDyK) TFA;Cyclic Arg-Gly-Asp-D-Tyr-Lys;CCyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK) trifluoroacetate;Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys);Cyclo(RGDyK) trifluoroacetate, 10 mM in DMSO;Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor;Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)
CBNumber: CB63121443
Molecular Formula: C29H42F3N9O10
Formula Weight: 733.7
MOL File: 250612-42-1.mol

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Cyclic Arg-Gly-Asp-D-Tyr-Lys Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white
Sequence: cyclo(Arg-Gly-Asp-{d-Tyr}-Lys)
InChIKey: KTQFOJMRRQLTAN-CNDMKARKNA-N
SMILES: C(F)(F)(F)C(=O)O.C(C1C=CC(O)=CC=1)[C@H]1NC([C@@H](NC(CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC1=O)=O)CC(=O)O)=O |&1:15,18,25,36,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H332Harmful if inhaled

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P312IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 25mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 50mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 100mg
Price: $890
Updated: 2021/12/16

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Cyclic Arg-Gly-Asp-D-Tyr-Lys Chemical Properties,Usage,Production

Uses

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Biological Activity

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

in vitro

Cyclo(RGDyK) showed higher affinity and selectivity for αVβ3 than αVβ5 and αIIbβ3. Cyclo(RGDyK)-bound micelles (TPM) promoted cell-specific uptake of DiI by B16-F10 cells and HUVECs through integrin-mediated endocytosis compared to Cyclo(RGDyK)-free micelles (NPM).

in vivo

Cyclo(RGDyK) (1 nmol, iv) inhibits the increase in αVβ3 integrin expression in the intima of left stenotic carotid arteries in apoE/ mice.

target

Target	Value
αVβ3 integrin	20 nM

IC 50

αvβ3: 20 nM (IC₅₀)

References

[1] Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36. PMID:11216533

Cyclic Arg-Gly-Asp-D-Tyr-Lys Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclic Arg-Gly-Asp-D-Tyr-Lys Suppliers

China 59 Japan 1 United States 8 Global 68

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View Lastest Price from Cyclic Arg-Gly-Asp-D-Tyr-Lys manufacturers

Career Henan Chemical Co

Product: Cyclic Arg-Gly-Asp-D-Tyr-Lys 250612-42-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

250612-42-1, Cyclic Arg-Gly-Asp-D-Tyr-LysRelated Search:

Cyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclo(RGDyK) trifluoroacetate

CCyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt

Cyclo(RGDyK) TFA

Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor

2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)

Cyclo(RGDyK) trifluoroacetate, 10 mM in DMSO

Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys)

250612-42-1