3-Hydroxymethylpyrrolidine
- Product Name
- 3-Hydroxymethylpyrrolidine
- CAS No.
- 5082-74-6
- Chemical Name
- 3-Hydroxymethylpyrrolidine
- Synonyms
- Albb-005836;AKOS BB-9752;DL-beta-Prolinol;DL-^b-Prolinol, 97+%;3-Pyrrolidinemethanol;3-pyrrolidinylmethanol;ASINEX-REAG BAS 10144565;PYRROLIDIN-3-YL-METHANOL;PYRROLIDINE-3-YL METHANOL;(RS)-3-Pyrrolidinemethanol
- CBNumber
- CB6312622
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 5082-74-6.mol
3-Hydroxymethylpyrrolidine Property
- Boiling point:
- 165-171℃
- Density
- 0.979
- Flash point:
- 86℃
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 14.93±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- Water Solubility
- Slightly soluble in water
- Sensitive
- Hygroscopic
- BRN
- 1420904
- InChI
- InChI=1S/C5H11NO/c7-4-5-1-2-6-3-5/h5-7H,1-4H2
- InChIKey
- QOTUIIJRVXKSJU-UHFFFAOYSA-N
- SMILES
- N1CCC(CO)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- P2000
- Product name
- Pyrrolidin-3-ylmethanol
- Purity
- min. 95.0 %
- Packaging
- 200MG
- Price
- $63
- Updated
- 2025/07/31
- Product number
- P2000
- Product name
- Pyrrolidin-3-ylmethanol
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $189
- Updated
- 2025/07/31
- Product number
- P999053
- Product name
- 3-Pyrrolidinemethanol
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 241434
- Product name
- Pyrrolidin-3-yl-methanol
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- P999053
- Product name
- 3-Pyrrolidinemethanol
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
3-Hydroxymethylpyrrolidine Chemical Properties,Usage,Production
Uses
3-?Pyrrolidinemethanoln is a useful reagent in preparation of orally active (heterocyclic aminomethyl)pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Synthesis
35309-35-4
85310-69-6
The general procedure for the synthesis of 3-pyrrolidinemethanol from methyl 5-oxopyrrolidine-3-carboxylate is as follows: 2 kg of methyl 5-oxo-3-pyrrolidinecarboxylate is dissolved in 20 liters of tetrahydrofuran, and 1.9 kg of sodium borohydride is added in batches at room temperature. Subsequently, 3.9 kg of boron trifluoride ether solution was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 10 minutes and then heated to reflux for about 4 hours. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate. The organic phases were combined and concentrated to give a light yellow oily liquid. This oily liquid was dissolved in ethanol, 500 g of sodium borohydride was added and heated to reflux for 2 hours. At the end of the reaction, the reaction was again quenched with water and extracted with ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate and saturated brine, and finally the organic phase was concentrated to give 1.2 kg of 3-pyrrolidinemethanol in 86% yield.
References
[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0032; 0034; 0039; 0042; 0044
3-Hydroxymethylpyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Hydroxymethylpyrrolidine Suppliers
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
View Lastest Price from 3-Hydroxymethylpyrrolidine manufacturers
- Product
- 3-Hydroxymethylpyrrolidine 5082-74-6
- Price
- US $100.00-2500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 5MT per month
- Release date
- 2025-05-19
- Product
- Pyrrolidin-3-ylmethanol 5082-74-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- 3-Hydroxymethylpyrrolidine 5082-74-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09