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RO9021

Product Name
RO9021
CAS No.
1446790-62-0
Chemical Name
RO9021
Synonyms
RO9021;CS-2533;RO-0921;RO 0921;RO-9021,Spleen tyrosine kinase,RO 9021,Inhibitor,inhibit,RO9021,Syk;3-Pyridazinecarboxamide, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-;6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
CBNumber
CB63152090
Molecular Formula
C18H25N7O
Formula Weight
355.44
MOL File
1446790-62-0.mol
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RO9021 Property

Boiling point:
618.5±55.0 °C(Predicted)
Density 
1.288±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
pka
14.25±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5899
Product name
RO9021
Purity
98.89%
Packaging
1mg
Price
$99
Updated
2021/12/16
ChemScene
Product number
CS-5899
Product name
RO9021
Purity
98.89%
Packaging
5mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-5899
Product name
RO9021
Purity
98.89%
Packaging
10mg
Price
$490
Updated
2021/12/16
ApexBio Technology
Product number
B6158
Product name
RO9021
Packaging
10mg
Price
$772
Updated
2021/12/16
ChemScene
Product number
CS-5899
Product name
RO9021
Purity
98.89%
Packaging
50mg
Price
$1450
Updated
2021/12/16
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RO9021 Chemical Properties,Usage,Production

Biological Activity

ro9021 is a syk inhibitor.spleen tyrosine kinase (syk) is identified as a critical integrator of intracellular signals regulated by activated immunoreceptors, such as fc receptors and bcell receptors (bcr), which are of great importantance for the function and development of lymphoid cells.

in vitro

previous study found that in addition to the suppression of bcell receptor signaling in human peripheral blood mononuclear cells and whole blood, fcγr signaling in human monocytes, and fc r signaling in human mast cells, ro9021 could also block the in vitro osteoclastogenesis from mouse bone marrow macrophages. moreover, the toll-like receptor 9 signaling in human bcells could be blocked by ro9021, leading to the decreased levels of plasmablasts, immunoglobulin (ig) g and igm upon b-cell differentiation. in addition, ro9021 could also potently inhibit type i interferon production by human plasmacytoid dendritic cells (pdc) via tlr9 activation, and such effect was found to be specific to tlr9 since ro9021 did not show inhibitary effect on tlr4- or jak-stat-mediated signaling [1].

in vivo

animal study showed that the oral administration of ro9021could significanly inhibit the arthritis progression in the mcia model, with well observed pharmacokinetics-pharmacodynamic correlation [1].

IC 50

5.6 nm

References

[1] liao c, et al. selective inhibition of spleen tyrosine kinase (syk) with a novel orally bioavailable small molecule inhibitor, ro9021, impinges on various innate and adaptive immune responses: implications for syk inhibitors in autoimmune disease therapy. arthritis res ther. 2013 oct 4;15(5):r146.

RO9021 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO9021 Suppliers

Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1446790-62-0, RO9021Related Search:


  • RO9021
  • RO-0921;RO 0921
  • CS-2533
  • 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
  • 3-Pyridazinecarboxamide, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-
  • RO-9021,Spleen tyrosine kinase,RO 9021,Inhibitor,inhibit,RO9021,Syk
  • 1446790-62-0