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Irofulven

Product Name: Irofulven
CAS No.: 920014-72-8
Chemical Name: Irofulven
Synonyms: RM-493;BIM-22493;IRC-022493);Setmelanodide;Sermelanotide;Setmelanotide (RM-493);RM-493; BIM-22493; IRC-022493);Setmelanotide (RM-493) trifluoroacetate salt;Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide
CBNumber: CB63159918
Molecular Formula: C49H68N18O9S2
Formula Weight: 1117.32
MOL File: 920014-72-8.mol

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Irofulven Property

Density: 1.54±0.1 g/cm3(Predicted)
pka: 12.82±0.70(Predicted)
form: Solid
color: White to off-white
Sequence: Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bond)
InChIKey: HDHDTKMUACZDAA-JFHGRQLZNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC10323
Product name: Setmelanotide
Purity: >98%
Packaging: 1g
Price: $2100
Updated: 2021/12/16

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Irofulven Chemical Properties,Usage,Production

Uses

Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].

in vivo

Inhibition of refeeding after an overnight fast by Setmelanotide is dependent on functional MC4R, and does not require MC3R. BIM-22493 acutely improves glucose homeostasis. Lep^ob/Lep^ob mice treated with BIM-22493 exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum glucose and HOMA-IR values^[1].
Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model^[2].

References

[1] Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. DOI:10.1016/j.peptides.2009.07.012
[2] Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7. DOI:10.2337/db12-0598

Irofulven Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Irofulven manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Setmelanotide 920014-72-8
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-29

Jinan Million Pharmaceutical Co., Ltd

Product: Irofulven 920014-72-8
Price: US $1.00-1.00/kg
Min. Order: 0.0001kg
Purity: 99%
Supply Ability: 50kg
Release date: 2025-01-01

Shandong Xuhuang New material CoLTD

Product: Setmelanotide 920014-72-8
Price: US $12.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100KG
Release date: 2025-02-26

920014-72-8, IrofulvenRelated Search:

N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine Melanotan 1 Pexiganan omiganan pentahydrochloride Acetyl Decapeptide-3 H-SER-ILE-LYS-VAL-ALA-VAL-OH Kisspeptin 10 (human) Hexapeptide 9 cilengitide PalMitoyl Tripeptide-1 Glutathione Cibinetide glucagon-like peptide 1 Palmitoyl Hexapeptide-12 Acetyl Dipeptide-1 cetyl ester IRL-1620 Hexapeptide-11 DERMASEPTIN PHYLLOMEDUSA SAUVAGII

Setmelanodide

BIM-22493

IRC-022493)

RM-493

RM-493; BIM-22493; IRC-022493)

Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2

L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide

Setmelanotide (RM-493) trifluoroacetate salt

Setmelanotide (RM-493)

Sermelanotide

(7S,16R,19R,22R)-16-((1H-imidazol-5-yl)methyl)-7-((1H-indol-3-yl) methyl)-22-((S)-2-acetamido-5-((diaminomethylene)amino) pentanamido)-13-benzyl-10-(3-((diaminomethylene)amino)propyl)-19-methyl-6,9,12,15,18,21- hexaoxo-1,2-dithia- 5,8,11,14,17,20- hexaazacyclotricosane-4-carboxamide

920014-72-8

C49H68N18O9S2